Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sharon K. Krueger"'
Autor:
Amy L. Palmer, Virginia L. Leykam, Andrew Larkin, Sharon K. Krueger, Ian R. Phillips, Elizabeth A. Shephard, David E. Williams
Publikováno v:
Pharmaceuticals, Vol 5, Iss 11, Pp 1147-1159 (2012)
Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs, including ethionamide (ETA). ETA is a prodrug bioactivated by mycobacterial and mammalian fl
Externí odkaz:
https://doaj.org/article/f1dc3703e69245a1835269e4be98fc6d
Autor:
Sandra L Uesugi, Graham Bench, William M. Baird, Lisbeth K. Siddens, Sharon K. Krueger, Ted J. Ognibene, Erin P. Madeen, David E. Williams, Jessica M. Hummel, Susan C. Tilton, Tammie J. McQuistan, Kim A. Anderson, Kenneth W. Turteltaub, Jordan N. Smith, Stuart Harris
Publikováno v:
Food and Chemical Toxicology. 115:136-147
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25872fafc218eeb49307558a759e562
https://doi.org/10.1016/j.fct.2018.03.003
https://doi.org/10.1016/j.fct.2018.03.003
Autor:
Lisa M. Bramer, Erin P. Madeen, Hannah You, William M. Baird, Sharon K. Krueger, Frank J. Gonzalez, Emily Ho, Katrina M. Waters, Roderick H. Dashwood, David E. Williams, Christiane V. Löhr, Lisbeth K. Siddens
Publikováno v:
Molecular Carcinogenesis. 56:163-171
The cytochrome P450 (CYP) 1 family is active toward numerous environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs). Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, we tested the hypothesis that hCYP1B1 is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb8b9a091918101f95363746c9cc73e
https://doi.org/10.1002/mc.22480
https://doi.org/10.1002/mc.22480
Autor:
Jessica M, Hummel, Erin P, Madeen, Lisbeth K, Siddens, Sandra L, Uesugi, Tammie, McQuistan, Kim A, Anderson, Kenneth W, Turteltaub, Ted J, Ognibene, Graham, Bench, Sharon K, Krueger, Stuart, Harris, Jordan, Smith, Susan C, Tilton, William M, Baird, David E, Williams
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 115
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is a known human carcinogen. In non-smoking adults greater than 95% of BaP exposure is through diet. The carcinogenicity of BaP is utilized by the U.S. EPA to assess relative potency of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1892ff2bc591e1094c588f5361f753d
https://pubmed.ncbi.nlm.nih.gov/29518434
https://pubmed.ncbi.nlm.nih.gov/29518434
Autor:
Christiane V. Löhr, David E. Williams, William M. Baird, Sharon K. Krueger, Lisbeth K. Siddens, Susan C. Tilton, Katrina M. Waters, Andrew Larkin
Publikováno v:
Toxicological Sciences. 146:135-145
Polycyclic aromatic hydrocarbons (PAHs) are a class of over 1500 chemicals formed as incomplete combustion products and released into the environment from both natural (e.g. forest fires) or anthropogenic (e.g. burning of fossil fuels, tobacco, charb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90878cf20b8b236617804659e472c79f
https://doi.org/10.1093/toxsci/kfv080
https://doi.org/10.1093/toxsci/kfv080
Autor:
Michael E. Garst, Marilyn C. Henderson, J. Fred Stevens, David E. Williams, Karen M. Kedzie, Wenkui K. Fang, Todd M. Heidelbaugh, Daniel W. Gil, Lisbeth K. Siddens, Phong X. Nguyen, Sharon K. Krueger, Ken Chow
Publikováno v:
Toxicology and Applied Pharmacology. 278:91-99
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ca8e926336cc75bb60f46f51b2e296
https://doi.org/10.1016/j.taap.2014.04.002
https://doi.org/10.1016/j.taap.2014.04.002
Publikováno v:
Biochemical Pharmacology. 89:141-147
Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂ upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0170a4626ccaa3b2b75273d568b99d87
https://doi.org/10.1016/j.bcp.2014.02.006
https://doi.org/10.1016/j.bcp.2014.02.006
Autor:
William M. Baird, Katrina M. Waters, Sharon K. Krueger, Andrew Larkin, Susan C. Tilton, David E. Williams, Lisbeth K. Siddens
Publikováno v:
Toxicology and Applied Pharmacology. 267:192-199
Polycyclic aromatic hydrocarbons (PAHs) are present in the environment as complex mixtures with components that have diverse carcinogenic potencies and mostly unknown interactive effects. Non-additive PAH interactions have been observed in regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f836b4d69aab4692847cec3692dcedd8
https://doi.org/10.1016/j.taap.2012.12.011
https://doi.org/10.1016/j.taap.2012.12.011
Autor:
Elizabeth A. Shephard, Virginia L. Leykam, Sharon K. Krueger, David E. Williams, Amy L. Palmer, Andrew Larkin, Ian Phillips
Publikováno v:
Pharmaceuticals; Volume 5; Issue 11; Pages: 1147-1159
Pharmaceuticals, Vol 5, Iss 11, Pp 1147-1159 (2012)
Pharmaceuticals
Pharmaceuticals, Vol 5, Iss 11, Pp 1147-1159 (2012)
Pharmaceuticals
Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs, including ethionamide (ETA). ETA is a prodrug bioactivated by mycobacterial and mammalian fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492949ef7bfa9fdfa6ed9c9ae810dd5
https://doi.org/10.3390/ph5111147
https://doi.org/10.3390/ph5111147
Autor:
David H. Phillips, Sharon K. Krueger, Susan C. Tilton, David E. Williams, Christopher A. Bradfield, Volker M. Arlt, Christiane V. Löhr, Cliff Pereira, William M. Baird, Andrew Larkin, Katrina M. Waters, Lisbeth K. Siddens
Publikováno v:
Toxicology and Applied Pharmacology
Siddens, L K, Larkin, A, Krueger, S K, Bradfield, C A, Waters, K M, Tilton, S C, Pereira, C B, Loehr, C V, Arlt, V M, Phillips, D H, Williams, D E & Baird, W M 2012, ' Polycyclic aromatic hydrocarbons as skin carcinogens : Comparison of benzo [a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse ', Toxicology and Applied Pharmacology, vol. 264, no. 3, pp. 377-386 . https://doi.org/10.1016/j.taap.2012.08.014
Siddens, L K, Larkin, A, Krueger, S K, Bradfield, C A, Waters, K M, Tilton, S C, Pereira, C B, Loehr, C V, Arlt, V M, Phillips, D H, Williams, D E & Baird, W M 2012, ' Polycyclic aromatic hydrocarbons as skin carcinogens : Comparison of benzo [a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse ', Toxicology and Applied Pharmacology, vol. 264, no. 3, pp. 377-386 . https://doi.org/10.1016/j.taap.2012.08.014
The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721051777f0913f0ce14e37b0b23ad8d