Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sharon J. Tollefson"'
Autor:
Yu Zhang, Jiuyang Xu, Margot Miranda-Katz, Jorna Sojati, Sharon J Tollefson, Michelle L Manni, John F Alcorn, Saumendra N Sarkar, John V Williams
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011840 (2024)
Human metapneumovirus (HMPV) is an important cause of acute lower respiratory infection in children and adults worldwide. There are four genetic subgroups of HMPV and both neutralizing antibodies and T cells contribute to protection. However, little
Externí odkaz:
https://doaj.org/article/6c53634f17784f9eb5425badd0b949ab
Autor:
Yu Zhang, Michelle L. Manni, Sharon J. Tollefson, Saumendra N. Sarkar, Margot Miranda-Katz, Jiuyang Xu, John V. Williams, Helen E. Rich, John F. Alcorn
Publikováno v:
Open Forum Infectious Diseases
Background Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in children and adults. However, mechanisms of pathogenesis are not fully understood. Methods We tested HMPV clinical and laboratory isolates in an established
Publikováno v:
The Journal of Immunology. 197:233-243
Viruses are frequent causes of lower respiratory infection (LRI). Programmed cell death-1 (PD-1) signaling contributes to pulmonary CD8+ T cell (TCD8) functional impairment during acute viral LRI, but the role of TCD8 impairment in viral clearance an
Programmed Death-1 Impairs Secondary Effector Lung CD8+ T Cells during Respiratory Virus Reinfection
Autor:
John J. Erickson, Sharon J. Tollefson, John V. Williams, Meredith C. Rogers, Andrew K. Hastings
Publikováno v:
The Journal of Immunology. 193:5108-5117
Reinfections with respiratory viruses are common and cause significant clinical illness, yet precise mechanisms governing this susceptibility are ill defined. Lung Ag-specific CD8+ T cells (TCD8) are impaired during acute viral lower respiratory infe
Publikováno v:
Antiviral Chemistry and Chemotherapy
Antiviral Chemistry & Chemotherapy
Antiviral Chemistry & Chemotherapy, Vol 27 (2019)
Antiviral Chemistry & Chemotherapy
Antiviral Chemistry & Chemotherapy, Vol 27 (2019)
Human metapneumovirus, a paramyxovirus discovered in 2001, is a major cause of lower respiratory infection in adults and children worldwide. There are no licensed vaccines or drugs for human metapneumovirus. We developed a fluorescent, cell-based med
Autor:
John T. Bates, Frances Smith-House, Sharon J. Tollefson, Robert E. Johnston, James C. Slaughter, Nancy Schultz-Darken, James E. Crowe, Monika Johnson, Nancy L. Davis, Jennifer E. Schuster, John V. Williams, Jennifer A. Pickens
Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are major causes of illness among children, the elderly, and the immunocompromised. No vaccine has been licensed for protection against either of these viruses. We tested the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15165db629172668ed3b666053caa41
Autor:
Andrew K. Hastings, Melissa B. Downing, Kelli L. Boyd, Joyce E. Johnson, Sebastian Joyce, Sharon J. Tollefson, Pavlo Gilchuk, Monika Johnson, Annette S. Kim, John J. Erickson, John V. Williams
Publikováno v:
Journal of Clinical Investigation
Viruses are leading causes of severe acute lower respiratory infections (LRIs). These infections evoke incomplete immunity, as individuals can be repeatedly reinfected throughout life. We report that acute viral LRI causes rapid pulmonary CD8+ cytoto
Publikováno v:
Vaccine. 28:4145-4152
Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GDeltaTM) that was secreted from mammalian cells and purifie
Autor:
Jiuyang Xu, Yu Zhang, Sharon J. Tollefson, Michelle L. Manni, Kevin J. McHugh, John F. Alcorn, Saumendra N. Sarkar, John V. Williams
Publikováno v:
The Journal of Immunology. 200:126.36-126.36
Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in infants and children. The disease outcome of HMPV infection ranges from mild infection to severe bronchiolitis and fatal pneumonia. HMPV was discovered in 2001 and its
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 77:58-58