Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sharon J. Scott"'
Autor:
Lina Gunnarsson, Bruno Campos, Paul L. Carmichael, Andrew White, John K. Colbourne, Geoff Hodges, Matthew P. Dent, Cecilie Rendal, Imran Shah, Carl Westmoreland, Paul Jennings, Claudia Rivetti, Steve Gutsell, Sharon J. Scott, Aude Kienzler, Ian Sorrel, Emma Butler, Luigi Margiotta-Casaluci, Fiona Sewell, Joshua A. Harrill, Richard S. Judson, Iris Muller, Stewart F. Owen, Timothy E. H. Allen, James B. Brown, Francesco Falciani, Mark R. Viant, Paul J. Russell
Publikováno v:
Toxicology in Vitro, 62:104692, 1-9. Elsevier Limited
Rivetti, C, Allen, T E H, Brown, J B, Butler, E, Carmichael, P L, Colbourne, J K, Dent, M, Falciani, F, Gunnarsson, L, Gutsell, S, Harrill, J A, Hodges, G, Jennings, P, Judson, R, Kienzler, A, Margiotta-Casaluci, L, Muller, I, Owen, S F, Rendal, C, Russell, P J, Scott, S, Sewell, F, Shah, I, Sorrel, I, Viant, M R, Westmoreland, C, White, A & Campos, B 2020, ' Vision of a near future: Bridging the human health–environment divide : Toward an integrated strategy to understand mechanisms across species for chemical safety assessment ', Toxicology in Vitro, vol. 62, 104692, pp. 1-9 . https://doi.org/10.1016/j.tiv.2019.104692
Rivetti, C, Allen, T E H, Brown, J B, Butler, E, Carmichael, P L, Colbourne, J K, Dent, M, Falciani, F, Gunnarsson, L, Gutsell, S, Harrill, J A, Hodges, G, Jennings, P, Judson, R, Kienzler, A, Margiotta-Casaluci, L, Muller, I, Owen, S F, Rendal, C, Russell, P J, Scott, S, Sewell, F, Shah, I, Sorrel, I, Viant, M R, Westmoreland, C, White, A & Campos, B 2020, ' Vision of a near future: Bridging the human health–environment divide : Toward an integrated strategy to understand mechanisms across species for chemical safety assessment ', Toxicology in Vitro, vol. 62, 104692, pp. 1-9 . https://doi.org/10.1016/j.tiv.2019.104692
There is a growing recognition that application of mechanistic approaches to understand cross-species shared molecular targets and pathway conservation in the context of hazard characterization, provide significant opportunities in risk assessment (R
Autor:
Yeyejide Adeleye, Matthew P. Dent, Andrew D. Scott, Sharon J. Scott, Sue Edwards, Melvin E. Andersen, Michael Davies, Beate Nicol, Paul L. Carmichael, Qiang Zhang, Rebecca A. Clewell, Paul Fowler, Carl Westmoreland, Andrew White, Bin Sun, Sophie Malcomber
Publikováno v:
Toxicology. 332:102-111
Risk assessment methodologies in toxicology have remained largely unchanged for decades. The default approach uses high dose animal studies, together with human exposure estimates, and conservative assessment (uncertainty) factors or linear extrapola