Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sharon H. Choi"'
Publikováno v:
Thrombosis and Haemostasis. 113:599-604
SummaryFactor Va enhances the rate of prothrombin activation by factor Xa by four to five orders of magnitude. Production of initiating levels of factor Va from its precursor, factor V, is a critical event early in haemostasis, as factor V exhibits n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30281532b518c634fc3d4cef8b1e4c58
https://doi.org/10.1160/th14-06-0515
https://doi.org/10.1160/th14-06-0515
Autor:
Sharon H. Choi, Julie N. R. Collins, Stephanie A. Smith, Richard J. Travers, Brian C. Cooley, James H. Morrissey
Publikováno v:
Blood. 120:5103-5110
Inorganic polyphosphates are linear polymers of orthophosphate that modulate blood clotting and inflammation. Polyphosphate accumulates in infectious microorganisms and is secreted by activated platelets; long-chain polyphosphate in particular is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ef68ee59cd9b735d7bb33bd173efaa
https://doi.org/10.1182/blood-2012-07-444935
https://doi.org/10.1182/blood-2012-07-444935
Publikováno v:
Blood. 118:6963-6970
Factor XI deficiency is associated with a bleeding diathesis, but factor XII deficiency is not, indicating that, in normal hemostasis, factor XI must be activated in vivo by a protease other than factor XIIa. Several groups have identified thrombin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f49129e36e7586560093e53fd2f787
https://doi.org/10.1182/blood-2011-07-368811
https://doi.org/10.1182/blood-2011-07-368811
Autor:
Stephanie A, Smith, Sharon H, Choi, Rebecca, Davis-Harrison, Jillian, Huyck, John, Boettcher, Chad M, Rienstra, Chad M, Reinstra, James H, Morrissey
Publikováno v:
Blood. 116:4353-4359
Polyphosphate, a linear polymer of inorganic phosphate, is secreted by activated platelets and accumulates in many infectious microorganisms. We recently showed that polyphosphate modulates the blood coagulation cascade at 3 steps: it triggers the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eadf16bc323c3d5465808900aedff49
https://doi.org/10.1182/blood-2010-01-266791
https://doi.org/10.1182/blood-2010-01-266791
Autor:
Teresa Helsten, Sharon H. Choi, Sanford J. Shattil, Mark H. Ginsberg, Thomas A. Bunch, Danny L. Brower, Alison L. Jannuzi, Hisashi Kato, Jun Yamanouchi, Chloé C. Féral
Publikováno v:
Molecular Biology of the Cell. 19:3589-3598
Integrin-mediated cell adhesion is essential for development of multicellular organisms. In worms, flies, and vertebrates, talin forms a physical link between integrin cytoplasmic domains and the actin cytoskeleton. Loss of either integrins or talin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b47b3bb3055420926bfc4c0de99cde
https://doi.org/10.1091/mbc.e08-01-0085
https://doi.org/10.1091/mbc.e08-01-0085
Autor:
Cristina Puy, András Gruber, Erik I Tucker, David Gailani, Stephanie A Smith, Sharon H Choi, James H Morrissey, Owen J McCarty
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Introduction: Our group has recently identified that alpha tissue factor pathway inhibitor (TFPIα) can be neutralized by activated factor XI (FXIa), accelerating plasma clotting time and fibrin generation, although this reaction was slow and require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c407fe0ee79654d7aab5290fcf5bd673
https://doi.org/10.1161/atvb.35.suppl_1.42
https://doi.org/10.1161/atvb.35.suppl_1.42
Publikováno v:
Clinical Cancer Research. 11:7003-7011
Purpose: Unfractionated heparin reduces metastasis in many murine models. Multiple mecha- nisms are proposed, particularly anticoagulation and/or inhibition of P-selectin and L-selectin. However, the doses used are not clinically tolerable and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e944d5a52731a6d4e9e02567e5a21f
https://doi.org/10.1158/1078-0432.ccr-05-1131
https://doi.org/10.1158/1078-0432.ccr-05-1131
Autor:
James H. Morrissey, Andras Gruber, Sharon H. Choi, Zoë C. Wong, David Gailani, Owen J. T. McCarty, Cristina Puy, Stephanie A. Smith, Erik I. Tucker
Inorganic polyphosphates (polyP), which are secreted by activated platelets (short-chain polyP) and accumulate in some bacteria (long-chain polyP), support the contact activation of factor XII (FXII) and accelerate the activation of FXI.The aim of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c80f3940942023c04acb88ce31fec07
https://europepmc.org/articles/PMC3714337/
https://europepmc.org/articles/PMC3714337/
Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91db1a69c7162f0ca8ba465d87916c03
https://europepmc.org/articles/PMC3383012/
https://europepmc.org/articles/PMC3383012/
Autor:
Rebecca L. Davis-Harrison, Chad M. Rienstra, Stephanie A. Smith, Julie N. R. Collins, James H. Morrissey, Sharon H. Choi
Polyphosphates, linear polymers of inorganic phosphates linked by phosphoanhydride bonds, are widely present among organisms and play diverse roles in biology, including functioning as potent natural modulators of the human blood clotting system. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf9b1cadc29575b184dd277dc1bb09a
https://europepmc.org/articles/PMC2976836/
https://europepmc.org/articles/PMC2976836/