Endothelial Dysfunction in Steatotic Human Donor Livers: A Pilot Study of the Underlying Mechanism During Subnormothermic Machine Perfusion

Autor: Irene Beijert, MD, Safak Mert, PhD, Viola Huang, MD, Negin Karimian, MD, Sharon Geerts, BSc, Ehab O.A. Hafiz, MD, James F. Markmann, MD, Heidi Yeh, MD, Robert J. Porte, MD, PhD, Korkut Uygun, PhD

Publikováno v: Transplantation Direct, Vol 4, Iss 5, p e345 (2018)

Background. Steatosis is a major risk factor for primary nonfunction in liver transplantations. Steatotic livers recover poorly from ischemia reperfusion injury, in part due to alterations in the microcirculation, although the exact mechanism is uncl

Externí odkaz: https://doaj.org/article/7a3620ec0b624d3399e347960721775c

Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies

Autor: Korkut Uygun, Martin L. Yarmush, Sharon Geerts, Negin Karimian, Ehab O A Hafiz, Siavash Raigani, Mohamed M. Aburawi, Fermin Fontan, Heidi Yeh, Paria Mahboub, Robert J. Porte, Viola Huang, Anna M Zhang, James F. Markmann, Irene Beijert, Sonal Nagpal

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0228011 (2020)
PLoS ONE
PLoS ONE, 15(1):e0228011. PUBLIC LIBRARY SCIENCE

There continues to be a significant shortage of donor livers for transplantation. One impediment is the discard rate of fatty, or steatotic, livers because of their poor post-transplant function. Steatotic livers are prone to significant ischemia-rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7687dfe958dc46ecd9e27db09595678e
https://research.rug.nl/en/publications/b86af8c5-0dea-4651-8672-ba6b8feec539

Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions

Autor: Murat Karabacak, Siavash Raigani, Florence Lin, Negin Karimian, Korkut Uygun, James F. Markmann, Sharon Geerts, Ehab O A Hafiz, Irene Beijert, Danielle Detelich, Viola Huang, Sinan Ozer, Peony D. Banik, Fermin Fontan, Heidi Yeh, Robert J. Porte, Mohamed M. Aburawi

Publikováno v: Journal of Clinical Medicine, Vol 9, Iss 1, p 269 (2020)
Journal of Clinical Medicine, 9(1):269. MDPI AG
Journal of Clinical Medicine
Volume 9
Issue 1

Ex situ machine perfusion is a promising technology to help improve organ viability prior to transplantation. However, preclinical studies using discarded human livers to evaluate therapeutic interventions and optimize perfusion conditions are limite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868bacabc2e0c662c5f407f24f721f1a
https://doi.org/10.3390/jcm9010269

Preparation of Decellularized Liver Scaffolds and Recellularized Liver Grafts

Autor: Sharon Geerts, Basak E. Uygun, Yibin Chen, Maria Jaramillo

Publikováno v: Methods in Molecular Biology ISBN: 9781493976553

Severe liver disease is the 12th leading cause of death in the USA, with organ transplantation often being the only viable option for treatment. However, due to the shortage of viable donor livers, it is estimated that over 1200 patients died in 2015

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22251818e2280d73a2969938c3e75cad
https://pubmed.ncbi.nlm.nih.gov/28735385

Nondestructive Methods for Monitoring Cell Removal During Rat Liver Decellularization

Autor: Sharon Geerts, Sinan Ozer, Maria Jaramillo, Martin L. Yarmush, Basak E. Uygun

Whole liver engineering holds the promise to create transplantable liver grafts that may serve as substitutes for donor organs, addressing the donor shortage in liver transplantation. While decellularization and recellularization of livers in animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80262fbc8217b775894afa52895fcd6
https://europepmc.org/articles/PMC4943465/