Data from Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas

Autor: Ruud H. Brakenhoff, Monique Slijper, C. René Leemans, Elisabeth Bloemena, Dirk J. Kuik, Albert J.R. Heck, Marijke Buijze, Boudewijn J.M. Braakhuis, Sharon Gauci, A. Peggy Graveland, Tieneke B.M. Schaaij-Visser

Purpose: The 5-year survival rates of head and neck squamous cell carcinomas (HNSCC) remain disappointing. HNSCCs develop in precursor fields of genetically altered cells that are often not completely resected when the tumor is excised, causing local

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb012f75e61a228d8e5795a2cfc21df
https://doi.org/10.1158/1078-0432.c.6517837.v1

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

Autor: René F. Ketting, Jeroen Krijgsveld, Boudewijn M.T. Burgering, Stefan Redl, Eugene Berezikov, Harmjan R. Vos, Hsin Yi Huang, Saskia Houwing, Amanda Meppelink, Peter Ladurner, Lucas J.T. Kaaij, Cecilia B. Moens, Bruce W. Draper, Sharon Gauci

Publikováno v: The EMBO Journal. 30:3298-3308

Piwi proteins function in an RNAi-like pathway that silences transposons. Piwi-associated RNAs, also known as piRNAs, act as a guide to identify Piwi targets. The tudor domain-containing protein Tdrd1 has been linked to this pathway but its function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72a9c91e484ed6568ab525a092abf479
https://doi.org/10.1038/emboj.2011.228

Orthogonal Separation Techniques for the Characterization of the Yeast Nuclear Proteome

Autor: Liesbeth M. Veenhoff, Albert J. R. Heck, Jeroen Krijgsveld, Sharon Gauci

Publikováno v: Journal of Proteome Research, 8(7), 3451-3463. NLM (Medline)

The presence of the nucleus is the distinguishing feature of eukaryotic cells, separating the genome from the cytoplasm. Key cellular events, including transcription, DNA replication, RNA-processing and ribosome biogenesis all take place in the nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84a3eab097790ae62c676a0e7ac6b6a
https://hdl.handle.net/11370/5c0f0c78-a70a-403b-a11b-bb253bbacc65

Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome

Autor: Sharon Gauci, Albert J. R. Heck, Bas van Breukelen, Monique Slijper, Shabaz Mohammed, Andreas O. Helbig, Reinout Raijmakers

Publikováno v: Molecularcellular proteomics : MCP. 9(5)

N-terminal processing of proteins is a process affecting a large part of the eukaryotic proteome. Although N-terminal processing is an essential process, not many large inventories are available, in particular not for human proteins. Here we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ffa669840969a2d93018d3d9e01d7b
https://pubmed.ncbi.nlm.nih.gov/20061308

Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas

Autor: Boudewijn J.M. Braakhuis, Marijke Buijze, Albert J. R. Heck, R.H. Brakenhoff, Sharon Gauci, Monique Slijper, A.P. Graveland, Tieneke B.M. Schaaij-Visser, C.R. Leemans, Elisabeth Bloemena, D.J. Kuik

Publikováno v: Clinical Cancer Research, 15(24), 7666-7675. American Association for Cancer Research Inc.
Schaaij-Visser, T B M, Graveland, A P, Gauci, S, Braakhuis, B J M, Buijze, M, Heck, A J R, Kuik, D J, Bloemena, E, Leemans, C R, Slijper, M & Brakenhoff, R H 2009, ' Differential proteomics identifies protein biomarkers that predict local relapse of head and neck squamous cell carcinomas ', Clinical Cancer Research, vol. 15, no. 15, pp. 7666-7675 . https://doi.org/10.1158/1078-0432.CCR-09-2134
Clinical Cancer Research, 15(15), 7666-7675. American Association for Cancer Research Inc.
Visser, B M, Graveland, A P, Gauci, S, Braakhuis, B J M, Buijze, M, Heck, A J, Kuik, D J, Bloemena, E, Leemans, C R, Slijper, M & Brakenhoff, R H 2009, ' Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas ', Clinical Cancer Research, vol. 15, no. 24, pp. 7666-7675 . https://doi.org/10.1158/1078-0432.CCR-09-2134

Purpose: The 5-year survival rates of head and neck squamous cell carcinomas (HNSCC) remain disappointing. HNSCCs develop in precursor fields of genetically altered cells that are often not completely resected when the tumor is excised, causing local

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b1d5180a60053d7b822747f1c580ef
https://research.vumc.nl/en/publications/7a2aaaac-5c97-4716-8f73-bd1b8203aa5b