Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Sharon G. Boots"'
1
Biomimetic polyene cyclizations. Synthesis of racemic 19-norprogesterone
Autor: William F. Huffman, William S. Johnson, Sharon G. Boots
Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 98:125-126
The aim of this study was to apply biomimetic cyclization strategy to a total synthesis of racemic 19-norprogesterone (8). Treatment of enone 1 with lithium aluminium hydride in ether afforded trienynol 2 which was cyclized with trifluoroacetic acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a28e89c294351198cf58da3d77077ac8
https://doi.org/10.1002/recl.19790980320
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2
Synthesis and Biological Evaluation of Potential Hypoglycemic Agents I: Carnitine Analogs
Autor: Sharon G. Boots, Marvin R. Boots
Publikováno v: Journal of Pharmaceutical Sciences. 64:1949-1952
A series of 4-dialkylamino-3-hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert-butyl 3,4-epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47773fc32a2448a6ecb47afcac98772
https://doi.org/10.1002/jps.2600641208
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4
An approach to taxodione involving biomimetic polyene cyclization methodology
Autor: Ashok B. Shenvi, Sharon G. Boots, William S. Johnson
Publikováno v: Tetrahedron. 38:1397-1404
A novel synthesis of 11,12-dimethoxyabieta-8,11,13-triene ( 4 ), involving the biomimetic cyclization of allylic alcohol 5 is described. This represents a formal total synthesis of taxodione ( 1 ), a tumor-inhibitory diterpenoid quinone methide. Trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b12cfd1fef5611bddfb09e595a3ec04
https://doi.org/10.1016/0040-4020(82)80219-6
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8
Hypocholesterolemic Agents II: Inhibition of β-Hydroxy-β-methylglutaryl Coenzyme A Reductase by Arylalkyl Hydrogen Succinates and Glutarates
Autor: Marvin R. Boots, Kenneth E. Guyer, Carole M. Noble, Sharon G. Boots
Publikováno v: Journal of Pharmaceutical Sciences. 62:952-957
A series of arylalkyl hydrogen succinates and glutarates was synthesized and assayed for inhibition of yeast β -hydroxy- β - methylglutaryl coenzyme A reductase. The following compounds were found to be particularly active as inhibitors: l-(4-biphe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca93c26041e8c07f6daa14aa512ba70
https://doi.org/10.1002/jps.2600620620
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9
Structural modification studies of 3-piperonylsydnone I. synthesis of piperonyl-substituted pyrazoles, isoxazoles, triazoles, oxadiazoles and thiadiazoles
Autor: Sharon G. Boots, C. C. Cheng
Publikováno v: Journal of Heterocyclic Chemistry. 4:272-283
As a structural modification study of the antimalarial compound 3-piperonylsydnone, a number of pyrazoles, isoxazoles, 1,2,4-triazoles, ψ-1,2,4-triazoles, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and their intermediates all of which contain the piperon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8f63532dc4e34f464c5bfdc3d3d1fa6
https://doi.org/10.1002/jhet.5570040219
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