Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Autor: Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate p

Externí odkaz: https://doaj.org/article/0bd1c20ec87342d695539812e636ba12

IFN-γ Drives human monocyte differentiation into highly proinflammatory macrophages that resemble a phenotype relevant to psoriasis

Autor: William L. Thompson, Rab K. Prinjha, Rosario Luque-Martin, Inmaculada Rioja, Menno P.J. de Winther, Sharon G. Bernard, Mathias Kalxdorf, Charlotte A. Ashby, Jan Van den Bossche, Catriona Sharp, Palwinder K. Mander, Annette E. Neele, Wouter J. de Jonge, Davina C. Angell, H. Christian Eberl, Johannes Freudenberg

Publikováno v: Luque-Martin, R, Angell, D C, Kalxdorf, M, Bernard, S, Thompson, W, Eberl, H C, Ashby, C, Freudenberg, J, Sharp, C, van den Bossche, J, de Jonge, W J, Rioja, I, Prinjha, R K, Neele, A E, de Winther, M P J & Mander, P K 2021, ' IFN-γ Drives human monocyte differentiation into highly proinflammatory macrophages that resemble a phenotype relevant to psoriasis ', Journal of Immunology, vol. 207, no. 2, pp. 555-568 . https://doi.org/10.4049/jimmunol.2001310
Journal of Immunology, 207(2), 555-568. American Association of Immunologists
Journal of immunology (Baltimore, Md., 207(2), 555-568. American Association of Immunologists

As key cells of the immune system, macrophages coordinate the activation and regulation of the immune response. Macrophages present a complex phenotype that can vary from homeostatic, proinflammatory, and profibrotic to anti-inflammatory phenotypes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc517f304ed2fe12bc5eeb2aa48c676
https://research.vumc.nl/en/publications/469e0fd3-afc0-42e4-9c7d-f61ecc14c6aa

Structure-based design of a bromodomain and extraterminal domain (BET) inhibitor selective for the N-terminal bromodomains that retains an anti-inflammatory and antiproliferative phenotype

Autor: James M. Woolven, William J. Kerr, Chun-wa Chung, Bhumika Karamshi, Beata S. Wyspiańska, John Evans, Emmanuel Hubert Demont, Laurie Gordon, Matthew J Lindon, Peter E. Soden, Rob Willis, Leanne Cutler, Darren J. Mitchell, Christopher Roland Wellaway, Antonia J. Lewis, Robert J. Watson, Paul Bamborough, Simon Taylor, Inmaculada Rioja, Sharon G. Bernard, Rab K. Prinjha, Peter D. Craggs

The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small molecule inhibitors of these proteins typically bind all eight bromod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2071ff9f599969eeda5e1e32f456446
https://strathprints.strath.ac.uk/73542/1/Wellaway_etal_JMC_2020_Structure_based_design_of_a_bromodomain_and_extraterminal_domain_BET_inhibitor.pdf