Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sharon E. Bickel"'
Autor:
Miranda M. Greig, Mark A. McPeek, Amrita A. Sontakke, Andrew S. Peloquin, Adrienne T. Perkins, Sharon E. Bickel
Publikováno v:
Chromosoma
The risk of meiotic segregation errors increases dramatically during a woman’s thirties, a phenomenon known as the maternal age effect. In addition, several lines of evidence indicate that meiotic cohesion deteriorates as oocytes age. One mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40a68567262c2c3edef398f9d2c61b7
http://europepmc.org/articles/PMC6823651
http://europepmc.org/articles/PMC6823651
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004607 (2014)
Chromosome segregation errors in human oocytes are the leading cause of birth defects, and the risk of aneuploid pregnancy increases dramatically as women age. Accurate segregation demands that sister chromatid cohesion remain intact for decades in h
Externí odkaz:
https://doaj.org/article/fbafa5c5c7f1417ba1be46aaf9dea973
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000263 (2008)
In humans, meiotic chromosome segregation errors increase dramatically as women age, but the molecular defects responsible are largely unknown. Cohesion along the arms of meiotic sister chromatids provides an evolutionarily conserved mechanism to kee
Externí odkaz:
https://doaj.org/article/fe9df98e9c8c46ada4dbb0867dc8ee9e
Autor:
Scott L Page, Radhika S Khetani, Cathleen M Lake, Rachel J Nielsen, Jennifer K Jeffress, William D Warren, Sharon E Bickel, R Scott Hawley
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000194 (2008)
The synaptonemal complex (SC) is an intricate structure that forms between homologous chromosomes early during the meiotic prophase, where it mediates homolog pairing interactions and promotes the formation of genetic exchanges. In Drosophila melanog
Externí odkaz:
https://doaj.org/article/8ad41d43f6134feab3c1a3da23fcac6b
Publikováno v:
Genetics. 203:173-189
Accurate segregation of homologous chromosomes during meiosis depends on their ability to remain physically connected throughout prophase I. For homologs that achieve a crossover, sister chromatid cohesion distal to the chiasma keeps them attached un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f283143f51864ec0b703272c626f931e
https://doi.org/10.1534/genetics.115.186460
https://doi.org/10.1534/genetics.115.186460
Autor:
Adrienne T, Perkins, Sharon E, Bickel
Publikováno v:
Journal of visualized experiments : JoVE. (130)
In humans, chromosome segregation errors in oocytes are responsible for the majority of miscarriages and birth defects. Moreover, as women age, their risk of conceiving an aneuploid fetus increases dramatically and this phenomenon is known as the mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f81d6b2d302031891e2975ed0ac0202
https://pubmed.ncbi.nlm.nih.gov/29286418
https://pubmed.ncbi.nlm.nih.gov/29286418
In humans, errors in meiotic chromosome segregation that produce aneuploid gametes increase dramatically as women age, a phenomenon termed the "maternal age effect." During meiosis, cohesion between sister chromatids keeps recombinant homologs physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0955189eddcaa13d930fa61857d89b05
https://europepmc.org/articles/PMC5098651/
https://europepmc.org/articles/PMC5098651/
Autor:
Radhika S. Khetani, Sharon E. Bickel
Publikováno v:
Journal of Cell Science. 120:3123-3137
During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila, null mutations in the ord gene abolish me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ed6c3054f778a1b9374a11ae8048a9
https://doi.org/10.1242/jcs.009977
https://doi.org/10.1242/jcs.009977
Publikováno v:
The Journal of Cell Biology
During meiosis, sister chromatid cohesion is required for normal levels of homologous recombination, although how cohesion regulates exchange is not understood. Null mutations in orientation disruptor (ord) ablate arm and centromeric cohesion during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979b333f64386e2c8289fc80e278f0e3
https://doi.org/10.1083/jcb.200310077
https://doi.org/10.1083/jcb.200310077
Publikováno v:
Genetics. 150:1467-1476
The Drosophila mei-S332 and ord gene products are essential for proper sister-chromatid cohesion during meiosis in both males and females. We have constructed flies that contain null mutations for both genes. Double-mutant flies are viable and fertil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3317126d9ea7277ac1079ad7cd011004
https://doi.org/10.1093/genetics/150.4.1467
https://doi.org/10.1093/genetics/150.4.1467