Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sharon C. Spence"'
Autor:
Sharon C. Spence, Dana B. DiBenedetti, Robyn T. Carson, Lauren Nelson, Sheri Fehnel, Fred T. Fiedorek
Publikováno v:
Clinical and Experimental Gastroenterology. 12:93-103
Background Diabetic gastroparesis (DG) is defined as delayed gastric emptying with associated gastrointestinal symptoms, without mechanical obstruction. Patient-reported symptoms are critical for diagnosis and evaluation of treatment benefit in DG. T
Autor:
Sheri Fehnel, Dana B. DiBenedetti, Lauren Nelson, Robyn T. Carson, Sharon C. Spence, Fred T. Fiedorek
Publikováno v:
Clinical and Experimental Gastroenterology.
Sheri Fehnel,1 Fred T Fiedorek,2 Lauren Nelson,1 Dana DiBenedetti,1 Sharon Spence,2 Robyn T Carson3 1Patient-Centered Outcomes Assessment, RTI Health Solutions, Research Triangle Park, NC, USA; 2Motus Therapeutics, Inc., Boston, MA, USA; 3Patient-Cen
Autor:
Sharon C. Spence, Fred T. Fiedorek, Richard W. McCallum, Michael Camilleri, Jan Tack, Keith Gottesdiener
Publikováno v:
Gastroenterology. 152:S139-S140
Autor:
Sharon C. Spence, Keith Gottesdiener, Elizabeth Stoner, Michelle Currie, Michael Camilleri, Anthony Lembo, Jeffery White, Richard W. McCallum, Ramon F. Sastre, Cristian F. Breton
Publikováno v:
Gastroenterology. 151(1)
Gastroparesis is an important complication of diabetes. We investigated the effects of relamorelin (a pentapeptide-selective agonist of the ghrelin receptor that speeds gastric emptying in patients with diabetes) in patients with diabetic gastropares
Autor:
Sharon C. Spence, Gururaj J. Kolar, Ernest P. Bouras, Alan R. Zinsmeister, Michael Camilleri, Keith Gottesdiener, Deborah Rhoten, Michael Ryks, Lawrence A. Szarka, Duane Burton, Maria I. Vazquez-Roque, Johanna Iturrino, Andres Acosta, Amy Boldingh
Publikováno v:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 13(13)
Ghrelin receptors are located in the colon. Relamorelin is a pentapeptide selective agonist of ghrelin receptor 1a with gastric effects, but its effects in the colon are not known. We aimed to evaluate the effects of relamorelin on bowel movements (B
Autor:
Fred T. Fiedorek, Sharon C. Spence, Keith Gottesdiener, Richard W. McCallum, Michael Camilleri, Jan Tack
Publikováno v:
Gastroenterology. 153:1240-1250.e2
Background & Aims Gastroparesis is a complication of diabetes with few treatment options. Relamorelin (also referred to as RM-131) is a selective, prokinetic agonist of ghrelin. We aimed to evaluate the efficacy of relamorelin on symptoms and gastric
Autor:
Margaret M. Sheahan, Marilyn K. Sanders, Debbie A. Daniel, Thomas P. Haverty, Sharon C. Spence
Publikováno v:
Current Therapeutic Research. 55:382-395
Since the initial report of the use of murine monoclonal antibody OKT3 for treatment of acute renal rejection, a significant body of information has been collected regarding the efficacy of OKT3 in reversing acute rejections in kidney, liver, and car
Autor:
Severine Vermeire, Sharon C. Spence, Sally Kennedy, Deborah Hartman, Scott M. Harris, Theodore Ptak, Barbara S. Fox, Ron E. Pruitt
Publikováno v:
American Journal of Gastroenterology. 109:S494-S495
Autor:
Ramon F. Sastre, Sharon C. Spence, Anthony Lembo, Elizabeth Stoner, Jeffery White, Michael Camilleri, Richard W. McCallum, Keith Gottesdiener, Cristian F. Breton
Publikováno v:
Gastroenterology. 146:S-158
Autor:
Morton Harfenist, Mark D. Reeves, Helen L. White, Mcgee Daniel Peter Claude, Diane M. Joseph, Sharon C. Spence
Publikováno v:
Journal of medicinal chemistry. 40(16)
Linear [6.6.6] tricyclic moieties whose center ring is made of two atoms of differing size (here primarily thioxanth-9-ones and phenoxathiins) monosubstituted meta to the sulfur by C(O)NHMe include potent and selective inhibitors of monoamine oxidase