Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sharon C. Lehec"'
Autor:
Suttiruk Jitraruch, Anil Dhawan, Robin D. Hughes, Celine Filippi, Sharon C. Lehec, Leanne Glover, Ragai R. Mitry
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Intraperitoneal transplantation of hepatocyte microbeads is an attractive option for the management of acute liver failure. Encapsulation of hepatocytes in alginate microbeads supports their function and prevents immune attack of the cells. Establish
Externí odkaz:
https://doaj.org/article/71d8bae42112478f8d0b39394ecc56d9
Autor:
Cheng-Maw Ho, Anil Dhawan, Robin D. Hughes, Sharon C. Lehec, Juliana Puppi, Christina Philippeos, Po-Huang Lee, Ragai R. Mitry
Publikováno v:
Asian Journal of Surgery, Vol 35, Iss 1, Pp 9-15 (2012)
Background/Objective: Hepatocyte transplantation is a promising alternative to liver transplantation in children with liver metabolic disorders and acute liver failure. Currently, it is difficult to assess rapidly hepatocyte function before transplan
Externí odkaz:
https://doaj.org/article/47acad8115ce4221af5ed96c6711aafc
Autor:
Emer Fitzpatrick, Yue Wu, Paramjeet Dhadda, Robin D. Hughes, Ragai R. Mitry, Hong Qin, Sharon C. Lehec, Nigel D. Heaton, Anil Dhawan
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Hepatocyte transplantation is becoming an accepted therapy for acute liver failure, either as a bridge to liver regeneration or to organ transplantation. Hepatocytes provide liver function in place of the failing organ. The maintenance of sufficient
Externí odkaz:
https://doaj.org/article/887687bd750c42f28300e658cdd0172c
Ex Vivo Magnetic Resonance Imaging of Transplanted Hepatocytes in a Rat Model of Acute Liver Failure
Autor:
Juliana Puppi, Michel Modo, Anil Dhawan, Sharon C. Lehec, Ragai R. Mitry, Robin D. Hughes Dr.
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Hepatocyte transplantation is being evaluated as an alternative to liver transplantation. However, the fate of hepatocytes after transplantation is not well defined. The aims of the study were to improve hepatocyte labeling in vitro using superparama
Externí odkaz:
https://doaj.org/article/975d47660acd4c1d88a650c346361237
Autor:
Filippos G. Sagias, Ragai R. Mitry, Robin D. Hughes, Sharon C. Lehec, Ameet G. Patel, Mohamed Rela, Giorgina Mieli-Vergani, Nigel D. Heaton, Anil Dhawan
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Hepatocyte transplantation is dependent on the availability of good quality human hepatocytes isolated from donor liver tissue. Hepatocytes obtained from livers rejected for transplantation on the grounds of steatosis are often of low viability and n
Externí odkaz:
https://doaj.org/article/5486c2ad0ce14215928f9f313b77bab8
Autor:
Sharon C. Lehec, Robin D. Hughes, Ragai R. Mitry, Michelle A. Graver, Anita Verma, Jim J. Wade, Anil Dhawan
Publikováno v:
Cell Transplantation, Vol 18 (2009)
Hepatocyte transplantation is being used in patients with liver-based metabolic disorders and acute liver failure. Hepatocytes are isolated from unused donor liver tissue under GMP conditions. Cells must be free of microbiological contamination to be
Externí odkaz:
https://doaj.org/article/48915f670a8641f2a083406c52a99def
Autor:
Alberto Quaglia, Sharon C. Lehec, Robin D. Hughes, Ragai R. Mitry, A. S. Knisely, Stephen Devereaux, Julie Richards, Mohamed Rela, Nigel D. Heaton, Bernard C. Portmann, Anil Dhawan
Publikováno v:
Cell Transplantation, Vol 17 (2008)
There are limited data regarding donor hepatocyte engraftment into recipient liver after human hepatocyte transplantation (HHTx). We reviewed the explant livers of seven children with metabolic disorders [ornithine-transcarbamylase deficiency (one),
Externí odkaz:
https://doaj.org/article/3637652dfb144ec99e8c9eafb1540cff
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Good quality cryopreserved human hepatocytes are becoming an important source for clinical hepatocyte transplantation. However, the process of cryopreservation leads to both structural and functional impairment of hepatocytes. The aim of this study w
Externí odkaz:
https://doaj.org/article/7bd6e7ff883f4e74a91d15fe2250b561
Autor:
Trinidad Serrano, Ragai R. Mitry, Claire Terry, Sharon C. Lehec, Anil Dhawan, Robin D. Hughes
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Calcineurin inhibitors (tacrolimus) and steroids continue to be an important component of hepatocyte transplantation protocols, despite reports of hepatotoxicity and inhibitory effects of steroids on cell proliferation. The aim of the study was to in
Externí odkaz:
https://doaj.org/article/5843c917171b4adaba6dae15e584b04a
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Successful cryopreservation of hepatocytes is essential to the future of hepatocyte transplantation as a treatment for liver disease, and also for the improved in vitro use of hepatocytes for research. However, hepatocyte function is adversely affect
Externí odkaz:
https://doaj.org/article/dd1e553149b0457f8a85d7a6c0bcdb85