Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sharon C. Hook"'
Autor:
Hadi Al-Hasani, Shosei Kishida, Sharon C. Hook, Alexandra Chadt, Jeremy M. Tavaré, Elaine C. Thomas, Kate J. Heesom
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Hook, S C, Chadt, A, Heesom, K J, Kishida, S, Al-Hasani, H, Tavaré, J M & Thomas, E C 2020, ' TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes ', Scientific Reports, vol. 10, 17953 (2020) . https://doi.org/10.1038/s41598-020-74661-1
Scientific Reports
Hook, S C, Chadt, A, Heesom, K J, Kishida, S, Al-Hasani, H, Tavaré, J M & Thomas, E C 2020, ' TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes ', Scientific Reports, vol. 10, 17953 (2020) . https://doi.org/10.1038/s41598-020-74661-1
Scientific Reports
Proteins involved in the spaciotemporal regulation of GLUT4 trafficking represent potential therapeutic targets for the treatment of insulin resistance and type 2 diabetes. A key regulator of insulin- and exercise-stimulated glucose uptake and GLUT4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3087938133f7ef640258072810ce4ba
https://doi.org/10.1038/s41598-020-74661-1
https://doi.org/10.1038/s41598-020-74661-1
Autor:
David Carling, Alexander Gray, Hadi Al-Hasani, Kate J. Heesom, Sharon C. Hook, D. Grahame Hardie, Alexandra Chadt, Jeremy M. Tavaré, Elaine C. Thomas
Publikováno v:
Biochemical Journal
Thomas, E, Hook, S C, Grey, A, Chadt, A, Carling, D, Al-Hasani, H, Heesom, K J, Hardie, G & Tavare, J 2018, ' Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity ', Biochemical Journal, vol. 475, no. 18, 475, pp. 2969-2983 . https://doi.org/10.1042/BCJ20180475
Thomas, E, Hook, S C, Grey, A, Chadt, A, Carling, D, Al-Hasani, H, Heesom, K J, Hardie, G & Tavare, J 2018, ' Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity ', Biochemical Journal, vol. 475, no. 18, 475, pp. 2969-2983 . https://doi.org/10.1042/BCJ20180475
AMP-activated protein kinase (AMPK) is a key regulator of cellular and systemic energy homeostasis which achieves this through the phosphorylation of a myriad of downstream targets. One target is TBC1D1 a Rab-GTPase-activating protein that regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b460c96ce5d44a36db03753f34791d34
http://europepmc.org/articles/PMC6156765
http://europepmc.org/articles/PMC6156765
Autor:
Sarah Meehan, Mark R. Wilson, David Klenerman, Richard W. Clarke, Benedetta Bolognesi, Kristina A. Ganzinger, Christopher M. Dobson, Angel Orte, Priyanka Narayan, Sharon C. Hook
Publikováno v:
Nature Structural & Molecular Biology. 19:79-83
In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease. We have examined the interactions between human clusterin and the Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4f451b14d848411ec180c4276ee6f
https://doi.org/10.1038/nsmb.2191
https://doi.org/10.1038/nsmb.2191