Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sharon C. Hook"'
Autor:
Hadi Al-Hasani, Shosei Kishida, Sharon C. Hook, Alexandra Chadt, Jeremy M. Tavaré, Elaine C. Thomas, Kate J. Heesom
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Hook, S C, Chadt, A, Heesom, K J, Kishida, S, Al-Hasani, H, Tavaré, J M & Thomas, E C 2020, ' TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes ', Scientific Reports, vol. 10, 17953 (2020) . https://doi.org/10.1038/s41598-020-74661-1
Scientific Reports
Hook, S C, Chadt, A, Heesom, K J, Kishida, S, Al-Hasani, H, Tavaré, J M & Thomas, E C 2020, ' TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes ', Scientific Reports, vol. 10, 17953 (2020) . https://doi.org/10.1038/s41598-020-74661-1
Scientific Reports
Proteins involved in the spaciotemporal regulation of GLUT4 trafficking represent potential therapeutic targets for the treatment of insulin resistance and type 2 diabetes. A key regulator of insulin- and exercise-stimulated glucose uptake and GLUT4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3087938133f7ef640258072810ce4ba
https://doi.org/10.1038/s41598-020-74661-1
https://doi.org/10.1038/s41598-020-74661-1
Autor:
David Carling, Alexander Gray, Hadi Al-Hasani, Kate J. Heesom, Sharon C. Hook, D. Grahame Hardie, Alexandra Chadt, Jeremy M. Tavaré, Elaine C. Thomas
Publikováno v:
Biochemical Journal
Thomas, E, Hook, S C, Grey, A, Chadt, A, Carling, D, Al-Hasani, H, Heesom, K J, Hardie, G & Tavare, J 2018, ' Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity ', Biochemical Journal, vol. 475, no. 18, 475, pp. 2969-2983 . https://doi.org/10.1042/BCJ20180475
Thomas, E, Hook, S C, Grey, A, Chadt, A, Carling, D, Al-Hasani, H, Heesom, K J, Hardie, G & Tavare, J 2018, ' Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity ', Biochemical Journal, vol. 475, no. 18, 475, pp. 2969-2983 . https://doi.org/10.1042/BCJ20180475
AMP-activated protein kinase (AMPK) is a key regulator of cellular and systemic energy homeostasis which achieves this through the phosphorylation of a myriad of downstream targets. One target is TBC1D1 a Rab-GTPase-activating protein that regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b460c96ce5d44a36db03753f34791d34
http://europepmc.org/articles/PMC6156765
http://europepmc.org/articles/PMC6156765
Autor:
Sarah Meehan, Mark R. Wilson, David Klenerman, Richard W. Clarke, Benedetta Bolognesi, Kristina A. Ganzinger, Christopher M. Dobson, Angel Orte, Priyanka Narayan, Sharon C. Hook
Publikováno v:
Nature Structural & Molecular Biology. 19:79-83
In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease. We have examined the interactions between human clusterin and the Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4f451b14d848411ec180c4276ee6f
https://doi.org/10.1038/nsmb.2191
https://doi.org/10.1038/nsmb.2191
Autor:
Simon, Annette
Neurodegenerative diseases are widespread disorders, with prevalence increasing with age. The first chapter of this book discusses autophagy, a cellular tool for the elimination of proteins that accumulate in neurodegenerative disorders and have path
Autor:
Giffard, Erica R.
Microglia are the resident brain immune cells of the central nervous system (CNS). These glial cells have an essential role in the CNS development and homeostasis, as well as in several diseases through the production of proinflammatory cytokines, tr