Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sharon Brouwer"'
Autor:
Maarten van den Berge, Jian Jiang, Laura Hesse, Martijin C Nawijn, Corneel J Vermeulen, Wim Timens, Nick H. T. ten Hacken, Marijn Berg, Orestes A Carpaij, Sarah A. Teichmann, Alen Faiz, Sharon Brouwer
Publikováno v:
Clinical and Experimental Allergy
Clinical and Experimental Allergy, 1428-1431. Wiley
ISSUE=12;STARTPAGE=1428;ENDPAGE=1431;ISSN=0954-7894;TITLE=Clinical and Experimental Allergy
Clinical and Experimental Allergy, 1428-1431. Wiley
ISSUE=12;STARTPAGE=1428;ENDPAGE=1431;ISSN=0954-7894;TITLE=Clinical and Experimental Allergy
Respiratory disease, characterized by changes in the cells of the lung, can affect molecular phenotype of cells and the intercellular interactions, resulting in a disbalance in the relative proportions of individual cell types. Understanding these ch
Autor:
Richard Beasley, Andy Lan, Ilse M. Boudewijn, Sharon Brouwer, Uilke Brouwer, Siebrig Schokker, Sebastiaan J. Vroegop, Henderik W. Frijlink, Paul Hagedoorn, Alen Faiz, Martijn C. Nawijn, Dirkje S. Postma, Claire A. Cox, Victor Guryev, Maarten van den Berge, David F. Choy, James Fingleton, Stephanie A. Christenson, Prescott G. Woodruff, Marissa Wisman
Publikováno v:
Allergy, 75(1), 191-194. Wiley-Blackwell
Autor:
Daniel E. Weeks, Qi Yan, Juan C. Celedón, Cancan Qi, Sharon Brouwer, Franziska Rosser, Yueh-Ying Han, Nadia Boutaoui, María Alvarez, Edna Acosta-Pérez, Judith M. Vonk, Cheng-Jian Xu, Yale Jiang, Angel Colón-Semidey, Ting Wang, Glorisa Canino, Erick Forno, Gerard H. Koppelman, Wei Chen
Publikováno v:
The Lancet Respiratory Medicine. 7:336-346
Summary Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that are associated with—and could accurately classify—atopy a
Autor:
Charlotte K. Billington, Gerard H. Koppelman, Liam G Heaney, Adel H. Mansur, Jenny Hankinson, Martijn C. Nawijn, Corry-Anke Brandsma, Sangita Bhaker, Andrew M. Fogarty, Dominick E. Shaw, Michael A. Portelli, Cornelis J. Vermeulen, Judith M. Vonk, Nick Shrine, Amanda P. Henry, Ian Sayers, Yohan Bossé, Maria Ketelaar, Martin D. Tobin, Peter H. Howarth, David C. Nickle, Néomi S. Grotenboer, Ma'en Obeidat, Gabrielle A. Lockett, John W. Holloway, Christopher E. Brightling, Alen Faiz, Rekha Chaudhuri, Tricia M. McKeever, Simon R. Johnson, Paul de Vos, Dirkje S. Postma, Zara Pogson, Neil C. Thomson, Sharon Brouwer, Maarten van den Berge, Angela Simpson, Amisha Singapuri, Robert Niven, F. Nicole Dijk, Ian P. Hall, Louise V. Wain, John D Blakey
Publikováno v:
Portelli, M A, Dijk, F N, Ketelaar, M E, Shrine, N, Hankinson, J, Bhaker, S, Grotenboer, N S, Obeidat, M, Henry, A P, Billington, C K, Shaw, D, Johnson, S R, Pogson, Z E, Fogarty, A, McKeever, T M, Nickle, D C, Bossé, Y, van den Berge, M, Faiz, A, Brouwer, S, Vonk, J M, de Vos, P, Brandsma, C-A, Vermeulen, C J, Singapuri, A, Heaney, L G, Mansur, A H, Chaudhuri, R, Thomson, N C, Holloway, J W, Lockett, G A, Howarth, P H, Niven, R, Simpson, A, Blakey, J D, Tobin, M D, Postma, D S, Hall, I P, Wain, L V, Nawijn, M C, Brightling, C E, Koppelman, G H & Sayers, I 2020, ' Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium ', JCI insight, vol. 5, no. 8, pp. 1-19 . https://doi.org/10.1172/jci.insight.132446
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def
Autor:
Fabian J. Theis, Maarten van den Berge, Marnix R. Jonker, Paulina M. Strzelecka, Ana Cvejic, Roser Vento-Tormo, Mirjana Efremova, Karen Affleck, Felipe A. Vieira Braga, Sarah A. Teichmann, Carlos Talavera-López, Herbert B. Schiller, Sharon Brouwer, Eirini S. Fasouli, Marijn Berg, Laura Hesse, Antoon J. M. van Oosterhout, Corry-Anke Brandsma, Gerard H. Koppelman, Lukas M. Simon, Helen V. Firth, Krzysztof Polanski, Kourosh Saeb-Parsy, Tomás Gomes, Subarna Palit, Kerstin B. Meyer, Ilias Angelidis, Marjan Luinge, Gozde Kar, Martijn C. Nawijn, Orestes A Carpaij, Wim Timens, Maximilian Strunz, Jian Jiang, Krishnaa T. Mahbubani
Publikováno v:
Nat. Med. 25, 1153-1163 (2019)
Nature Medicine, 25(7), 1153-1163. Nature Publishing Group
Nature Medicine
Nature medicine, 25(7), 1153-1163. Nature Publishing Group
Nature Medicine, 25(7), 1153-1163. Nature Publishing Group
Nature Medicine
Nature medicine, 25(7), 1153-1163. Nature Publishing Group
Human lungs enable efficient gas exchange and form an interface with the environment, which depends on mucosal immunity for protection against infectious agents. Tightly controlled interactions between structural and immune cells are required to main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6769ea082e29de0408a2fcd2b3a15168
https://www.repository.cam.ac.uk/handle/1810/292289
https://www.repository.cam.ac.uk/handle/1810/292289
Autor:
Sharon Brouwer, Cancan Qi, Qi Yan, Juan C. Celedón, Nadia Boutaoui, Gerard H. Koppelman, Daniel E. Weeks, Judith M. Vonk, Edna Acosta-Pérez, Ting Wang, Glorisa Canino, Franziska Rosser, Angel Colón-Semidey, Yueh-Ying Han, Maria Alvarez, Wei Chen, Erick Forno, Yale Jiang, Cheng-Jian Xu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 199. AMER THORACIC SOC
Autor:
M. van den Berge, Anna-Carin Olin, Huib A. M. Kerstjens, Sharon Brouwer, Martijn C. Nawijn, Orestes A Carpaij
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 199. AMER THORACIC SOC
Autor:
Martijn C. Nawijn, Sarah A. Teichmann, Maarten van den Berge, Sharon Brouwer, Marijn Berg, Orestes A Carpaij, Gozde Kar, Felipe A. Vieira Braga
Publikováno v:
European Respiratory Journal, 52. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Asthma is a chronic inflammatory disease with structural changes in the airway wall, including goblet cell metaplasia, loss of ciliated epithelial cells, basement membrane thickening and airway smooth muscle hypertrophy and hyperplasia. To characteri
Autor:
Qi Yan, Ting Wang, Yueh-Ying Han, Maria Alvarez, Wei Chen, Cancan Qi, J. M. Vonk, Sharon Brouwer, Cheng-Jian Xu, Juan C. Celedón, Nadia Boutaoui, Gerard H. Koppelman, Franziska Rosser, Edna Acosta-Pérez, Daniel E. Weeks, Yale Jiang, Glorisa Canino, Erick Forno, Angel Colón-Semidey
Publikováno v:
SSRN Electronic Journal.
BACKGROUND: Up to 10-12% of U.S. children and adolescents report respiratory or skin allergies. Epigenetic mechanisms may alter the airway epithelial barrier and ultimately lead to atopic diseases. Here we aim to identify DNA methylation profiles tha
Autor:
Don D. Sin, Maarten van den Berge, Rudolf S N Fehrmann, Sharon Brouwer, Juha Karjalainen, Peter D. Paré, Michel Laviolette, Corry-Anke Brandsma, Wim Timens, Marnix R. Jonker, Dirkje S. Postma, Yohan Bossé, Anita I.R. Spanjer, Ke Hao, Lude Franke, David C. Nickle
Publikováno v:
Thorax, 70(1), 21-32. BMJ PUBLISHING GROUP
Background Chronic obstructive pulmonary disease (COPD) is a progressive, incurable lung disease characterised by abnormal tissue repair causing emphysema and small airways fibrosis. Since current therapy cannot modify this abnormal repair, it is cru