A mechanism regulating the onset of Sox2 expression in the embryonic neural plate.

Autor: Costis Papanayotou, Anne Mey, Anne-Marie Birot, Yasushi Saka, Sharon Boast, Jim C Smith, Jacques Samarut, Claudio D Stern

Publikováno v: PLoS Biology, Vol 6, Iss 1, p e2 (2008)

In vertebrate embryos, the earliest definitive marker for the neural plate, which will give rise to the entire central nervous system, is the transcription factor Sox2. Although some of the extracellular signals that regulate neural plate fate have b

Externí odkaz: https://doaj.org/article/32f7ab3ffd2b4a5bad1fad64176a1616

Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy

Autor: Baojie Li, Peiquan Zhao, Yong Cang, Yi-Han Chen, Hao Jia, Huijuan Liu, Tielin Zhou, Helene Thibault, Jing Li, Lin He, Stephen P. Goff, Deyong Jia, Sharon Boast, Marielle Scherrer-Crosbie

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (51), pp.15666-71. ⟨10.1073/pnas.1518368112⟩

International audience; Protein palmitoylation regulates many aspects of cell function and is carried out by acyl transferases that contain zf-DHHC motifs. The in vivo physiological function of protein palmitoylation is largely unknown. Here we gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31a79c710b80dbfa5f83da29b167a6d
https://doi.org/10.1073/pnas.1518368112

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

Autor: Qing Zhang, H. Shelton Earp, Todd D. Camenisch, Qingxian Lu, Rüdiger Klein, Cary Lai, Stephen P. Goff, Sharon Boast, Franca Casagranda, Greg Lemke, Michael K. Skinner, Glenn K. Matsushima, Martin Gore

Publikováno v: Nature. 398:723-728

We have generated and analysed null mutations in the mouse genes encoding three structurally related receptors with tyrosine kinase activity: Tyro 3, Axl, and Mer. Mice lacking any single receptor, or any combination of two receptors, are viable and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c6eb3d64878206c45f846cca3df17
https://doi.org/10.1038/19554

Abnormal Peripheral Lymphocyte Function in c-ablMutant Mice

Autor: Stephen P. Goff, Frederick W. Alt, Alan M. Stall, Pamela L. Schwartzberg, Grace M. Lee, Jeff D. Hardin, Sharon Boast

Publikováno v: Cellular Immunology. 172:100-107

The proto-oncogene c-abl encodes a tyrosine kinase that is hypothesized to function in proliferation-stimulatory signaling pathways. Previous work on mice homozygous for targeted mutations in the c-abl gene (ablml and abl2 mutant strains) has demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156988647b4f3d66dbb98b4aadba476c
https://doi.org/10.1006/cimm.1996.0220

A mechanism regulating the onset of Sox2 expression in the embryonic neural plate

Autor: James C. Smith, Costis Papanayotou, Anne-Marie Birot, Anne Mey, Sharon Boast, Yasushi Saka, Claudio D. Stern, Jacques Samarut

Publikováno v: PLoS Biology
PLoS Biology, Public Library of Science, 2008, 6 (1), pp.109-123. ⟨10.1371/journal.pbio.0060002⟩
PLoS Biology, 2008, 6 (1), pp.109-123. ⟨10.1371/journal.pbio.0060002⟩
PLoS Biology, Vol 6, Iss 1, p e2 (2008)
Plos Biology 1 (6), 109-123. (2008)

In vertebrate embryos, the earliest definitive marker for the neural plate, which will give rise to the entire central nervous system, is the transcription factor Sox2. Although some of the extracellular signals that regulate neural plate fate have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc644ac6e09340e134e8ef4a901706c
https://hal.inrae.fr/hal-02662617/file/2008_Papanayotou_pbio_1.pdf