Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sharon Benzeno"'
Autor:
Heather M. Callaway, Kathryn M. Hastie, Sharon L. Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, S. Moses Dennison, Kan Li, Michael D. Alpert, Charles C. Bailey, Sharon Benzeno, Jody L. Bonnevier, Jin-Qiu Chen, Charm Chen, Hyeseon Cho, Peter D. Crompton, Vincent Dussupt, Kevin C. Entzminger, Yassine Ezzyat, Jonathan K. Fleming, Nick Geukens, Amy E. Gilbert, Yongjun Guan, Xiaojian Han, Christopher J. Harvey, Julia M. Hatler, Bryan Howie, Chao Hu, Ailong Huang, Maya Imbrechts, Aishun Jin, Nik Kamachi, Gladys Keitany, Mark Klinger, Jay K. Kolls, Shelly J. Krebs, Tingting Li, Feiyan Luo, Toshiaki Maruyama, Michael A. Meehl, Letzibeth Mendez-Rivera, Andrea Musa, C.J. Okumura, Benjamin E.R. Rubin, Aaron K. Sato, Meiying Shen, Anirudh Singh, Shuyi Song, Joshua Tan, Jeffrey M. Trimarchi, Dhruvkumar P. Upadhyay, Yingming Wang, Lei Yu, Tom Z. Yuan, Erik Yusko, Bjoern Peters, Georgia Tomaras, Erica Ollmann Saphire
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112014- (2023)
Summary: The SARS-CoV-2 Omicron variant of concern (VoC) and its sublineages contain 31–36 mutations in spike and escape neutralization by most therapeutic antibodies. In a pseudovirus neutralization assay, 66 of the nearly 400 candidate therapeuti
Externí odkaz:
https://doaj.org/article/61e61f138daa45d1ba9a2edb473cf0bc
Autor:
Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, Rachel M. Gittelman, Jun Li, Won-Chul Lee, Junya Fujimoto, Carmen Behrens, Xiaoke Liu, Feng Wang, Kelly Quek, Chunlin Wang, Farrah Kheradmand, Runzhe Chen, Chi-Wan Chow, Heather Lin, Chantale Bernatchez, Ali Jalali, Xin Hu, Chang-Jiun Wu, Agda Karina Eterovic, Edwin Roger Parra, Erik Yusko, Ryan Emerson, Sharon Benzeno, Marissa Vignali, Xifeng Wu, Yuanqing Ye, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Tina Cascone, Alexandra Snyder, Jennifer A. Wargo, Roy Herbst, Stephen Swisher, Humam Kadara, Cesar Moran, Neda Kalhor, Jianhua Zhang, Paul Scheet, Ara A. Vaporciyan, Boris Sepesi, Don L. Gibbons, Harlan Robins, Patrick Hwu, John V. Heymach, Padmanee Sharma, James P. Allison, Veera Baladandayuthapani, Jack J. Lee, Mark M. Davis, Ignacio I. Wistuba, P. Andrew Futreal, Jianjun Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tiss
Externí odkaz:
https://doaj.org/article/15a3818a702a41f18e727456b0714f76
Autor:
Alexandra Snyder, Tavi Nathanson, Samuel A Funt, Arun Ahuja, Jacqueline Buros Novik, Matthew D Hellmann, Eliza Chang, Bulent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S Robins, Elaine R Mardis, Taha Merghoub, Jeff Hammerbacher, Jonathan E Rosenberg, Dean F Bajorin
Publikováno v:
PLoS Medicine, Vol 14, Iss 5, p e1002309 (2017)
BACKGROUND:Inhibition of programmed death-ligand 1 (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients with metastatic urothelial cancers, including complete remissions in patients with chemotherapy refractory disease. Alt
Externí odkaz:
https://doaj.org/article/dce1a7888e3c4bdeb85b68605ddcef52
Autor:
Jianjun Zhang, Ignacio I. Wistuba, P. Andrew Futreal, James P. Allison, Padmanee Sharma, J. Jack Lee, Harlan Robins, John V. Heymach, Stephen Swisher, William N. William, Jennifer A. Wargo, Don L. Gibbons, Boris Sepesi, Chantale Bernatchez, Sharon Benzeno, Carmen Behrens, Cara Haymaker, Lorenzo Federico, Marie-Andrée Forget, Curtis Gumbs, Latasha D. Little, Edwin R. Parra, Jaime Rodriguez-Canales, Junya Fujimoto, Marissa Vignali, Tina Cascone, Luis M. Vence, Runzhe Chen, Vancheswaran Gopalakrishnan, Kelly Quek, Jun Li, Christopher Tipton, Jianhua Zhang, Ryan Emerson, Chang-Jiun Wu, Erik C. Yusko, Jiexin Zhang, Jianjun Gao, Rachel Gittelman, Alexandre Reuben
Supplemental Figure S1. Number of predicted neoantigens. Supplemental Figure S2. Association between expressed branch predicted neoantigens and relapse. Supplemental Figure S3. Substantial ITH in the number of unique T cell rearrangements. Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949e59717c7cf38401c916522c9da2df
https://doi.org/10.1158/2159-8290.22532243
https://doi.org/10.1158/2159-8290.22532243
Autor:
Jianjun Zhang, Ignacio I. Wistuba, P. Andrew Futreal, James P. Allison, Padmanee Sharma, J. Jack Lee, Harlan Robins, John V. Heymach, Stephen Swisher, William N. William, Jennifer A. Wargo, Don L. Gibbons, Boris Sepesi, Chantale Bernatchez, Sharon Benzeno, Carmen Behrens, Cara Haymaker, Lorenzo Federico, Marie-Andrée Forget, Curtis Gumbs, Latasha D. Little, Edwin R. Parra, Jaime Rodriguez-Canales, Junya Fujimoto, Marissa Vignali, Tina Cascone, Luis M. Vence, Runzhe Chen, Vancheswaran Gopalakrishnan, Kelly Quek, Jun Li, Christopher Tipton, Jianhua Zhang, Ryan Emerson, Chang-Jiun Wu, Erik C. Yusko, Jiexin Zhang, Jianjun Gao, Rachel Gittelman, Alexandre Reuben
Table S1. Patient demographics and characteristics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4203eb6c32df622ec8f5c07853a1a9
https://doi.org/10.1158/2159-8290.22532240.v1
https://doi.org/10.1158/2159-8290.22532240.v1
Autor:
Jianjun Zhang, Ignacio I. Wistuba, P. Andrew Futreal, James P. Allison, Padmanee Sharma, J. Jack Lee, Harlan Robins, John V. Heymach, Stephen Swisher, William N. William, Jennifer A. Wargo, Don L. Gibbons, Boris Sepesi, Chantale Bernatchez, Sharon Benzeno, Carmen Behrens, Cara Haymaker, Lorenzo Federico, Marie-Andrée Forget, Curtis Gumbs, Latasha D. Little, Edwin R. Parra, Jaime Rodriguez-Canales, Junya Fujimoto, Marissa Vignali, Tina Cascone, Luis M. Vence, Runzhe Chen, Vancheswaran Gopalakrishnan, Kelly Quek, Jun Li, Christopher Tipton, Jianhua Zhang, Ryan Emerson, Chang-Jiun Wu, Erik C. Yusko, Jiexin Zhang, Jianjun Gao, Rachel Gittelman, Alexandre Reuben
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b75bea507ebdee99bae2f36fbbc6983
https://doi.org/10.1158/2159-8290.22532246
https://doi.org/10.1158/2159-8290.22532246
Autor:
Tina Cascone, P. Andrew Futreal, Chang-Jiun Wu, Lorenzo Federico, J. Jack Lee, Ignacio I. Wistuba, Harlan Robins, John V. Heymach, Carmen Behrens, Chantale Bernatchez, Alexandre Reuben, Runzhe Chen, Stephen G. Swisher, Jennifer A. Wargo, Rachel M. Gittelman, Jianhua Zhang, Marissa Vignali, Boris Sepesi, Latasha Little, Marie Andrée Forget, Jianjun Zhang, Jaime Rodriguez-Canales, Ryan O. Emerson, Erik Yusko, Vancheswaran Gopalakrishnan, Jianjun Gao, Kelly Quek, Luis M Vence, Sharon Benzeno, William N. William, Don L. Gibbons, Cara Haymaker, Jun Li, Padmanee Sharma, Christopher M. Tipton, Junya Fujimoto, James P. Allison, Edwin Roger Parra, Curtis Gumbs, Jiexin Zhang
Publikováno v:
Cancer Discovery. 7:1088-1097
Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens, were shown to alter tumor immunogenicity through T-cell responses. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeca6895b031e0558f6f4d15e45add79
https://doi.org/10.1158/2159-8290.cd-17-0256
https://doi.org/10.1158/2159-8290.cd-17-0256
Autor:
Wendy M. Blumenschein, Kelsey Baker, Bailey Donahue, Jennifer H. Yearley, Terrill K. McClanahan, Benjamin Hoch, Erin Murphy, Yuzheng Zhang, Marissa Vignali, Lee D. Cranmer, Stanley R. Riddell, Robin L. Jones, Sara Cooper, Matthew B. Spraker, Ryan O. Emerson, Seth M. Pollack, Steven M. Townson, Elizabeth T. Loggers, Qianchuan He, Y. David Seo, Venu G. Pillarisetty, Sharon Benzeno, Mary W. Redman, Robert W. Ricciotti
Publikováno v:
Cancer. 123:3291-3304
BACKGROUND Patients with metastatic sarcomas have poor outcomes and although the disease may be amenable to immunotherapies, information regarding the immunologic profiles of soft tissue sarcoma (STS) subtypes is limited. METHODS The authors identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d2d7cbbc6341ae137a4fde740cd559
https://doi.org/10.1002/cncr.30726
https://doi.org/10.1002/cncr.30726
Autor:
Roy S. Herbst, James P. Allison, Kelly Quek, Edwin R. Parra, Samantha Tippen, Harlan Robins, Chi Wan Chow, Alexandre Reuben, Runzhe Chen, Erik Yusko, Padmanee Sharma, Xizeng Mao, Jiexin Zhang, John V. Heymach, Patrick Hwu, Boris Sepesi, Jun Li, Yuanqing Ye, Jianhua Zhang, Humam Kadara, Carmen Behrens, Rebecca Thornton, Farrah Kheradmand, Neda Kalhor, Xin Hu, Latasha Little, P. Andrew Futreal, Paul Scheet, Alexandra Snyder, Tina Cascone, Sharon Benzeno, Don L. Gibbons, Won-Chul Lee, Xiaoke Liu, Veera Baladandayuthapani, Xifeng Wu, Jack Lee, Cesar A. Moran, Ignacio I. Wistuba, Ara A. Vaporciyan, Ali Jalali, Chunlin Wang, Junya Fujimoto, Xingzhi Song, Heather Lin, Curtis Gumbs, Mark M. Davis, Feng Wang, Ryan O. Emerson, Chantale Bernatchez, Jennifer A. Wargo, Shin Heng Chiou, Chang-Jiun Wu, Stephen G. Swisher, Marissa Vignali, Rachel M. Gittelman, Agda Karina Eterovic, Jianjun Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ab19d34720c6f4935a6bc53a658142
https://pubmed.ncbi.nlm.nih.gov/32001676
https://pubmed.ncbi.nlm.nih.gov/32001676
Autor:
Adria Carbo, Mark Klinger, Harlan Robins, Tim Hayes, Edward J. Osborne, Sharon Benzeno, Ruth Taniguchi, Peter Ebert, Melanie Laur, Joyce K. Hu, Erica Eggers
Publikováno v:
Cancer Immunology Research. 7:B115-B115
Therapeutic vaccines have been in development for decades with the goal of priming and boosting an immune response against specific antigens in cancer patients. More recently, vaccination with mutation-derived neoantigens has emerged as is an attract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974532f9f20ca9149434a0cef1585a27
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b115
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b115