Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sharon Aviran"'
Autor:
P. Daniela Garcia, Robert W. Leach, Gable M. Wadsworth, Krishna Choudhary, Hua Li, Sharon Aviran, Harold D. Kim, Virginia A. Zakian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nucl
Externí odkaz:
https://doaj.org/article/60a84cb1852b4201965cf90b77707313
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-26 (2019)
Abstract RNA biology is revolutionized by recent developments of diverse high-throughput technologies for transcriptome-wide profiling of molecular RNA structures. RNA structurome profiling data can be used to identify differentially structured regio
Externí odkaz:
https://doaj.org/article/816fd80b11cc4075abcadd25a9fab25b
Autor:
Mirko Ledda, Sharon Aviran
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract Establishing a link between RNA structure and function remains a great challenge in RNA biology. The emergence of high-throughput structure profiling experiments is revolutionizing our ability to decipher structure, yet principled approaches
Externí odkaz:
https://doaj.org/article/c18b874cafd94a08b979b4312a5f6215
Autor:
Hua Li, Sharon Aviran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Different experimental and computational approaches can be used to study RNA structures. Here, the authors present a computational method for data-directed reconstruction of complex RNA structure landscapes, which predicts a parsimonious set of co-ex
Externí odkaz:
https://doaj.org/article/a4ce7826408646cbb8880ad8331024ff
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207029 (2018)
RNA SHAPE experiments have become important and successful sources of information for RNA structure prediction. In such experiments, chemical reagents are used to probe RNA backbone flexibility at the nucleotide level, which in turn provides informat
Externí odkaz:
https://doaj.org/article/e58fb8fe2f81425dbd74bb06b547465f
Autor:
Hua Li, Sharon Aviran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained an error in Figure 2, due to a typesetting error. Panels d and e were positioned such that the locations of the mutations in panel d did not align correctly with the corresponding nucleotides
Externí odkaz:
https://doaj.org/article/0388e0f52fc844d88d7f31e61e8cb0d1
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 8 (2010)
Gene therapy is an emerging alternative to conventional anti-HIV-1 drugs, and can potentially control the virus while alleviating major limitations of current approaches. Yet, HIV-1's ability to rapidly acquire mutations and escape therapy presents a
Externí odkaz:
https://doaj.org/article/dd0704f1e6974b6a86c82fed30cc5dcd
Autor:
James Wang, Brett Z. Fite, Aris J. Kare, Bo Wu, Marina Raie, Spencer K. Tumbale, Nisi Zhang, Ryan R. Davis, Clifford G. Tepper, Sharon Aviran, Aaron M. Newman, Daniel A. King, Katherine W. Ferrara
Publikováno v:
Theranostics, vol 12, iss 18
Background: Although combination immunotherapies incorporating local and systemic components have shown promising results in treating solid tumors, varied tumor microenvironments (TMEs) can impact immunotherapeutic efficacy. Method: We designed and e
Rapid structure-function insights via hairpin-centric analysis of big RNA structure probing datasets
Publikováno v:
NAR Genomics and Bioinformatics
NAR genomics and bioinformatics, vol 3, iss 3
NAR genomics and bioinformatics, vol 3, iss 3
The functions of RNA are often tied to its structure, hence analyzing structure is of significant interest when studying cellular processes. Recently, large-scale structure probing (SP) studies have enabled assessment of global structure-function rel
Autor:
Sharon Aviran, Danny Incarnato
Publikováno v:
Journal of Molecular Biology. 434:167635
RNA structure probing experiments have emerged over the last decade as a straightforward way to determine the structure of RNA molecules in a number of different contexts. Although powerful, the ability of RNA to dynamically interconvert between, and