Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sharon A. Townson"'
Publikováno v:
Biomolecular NMR Assignments. 13:227-231
K-Ras exists in two distinct structural conformations specific to binding of GDP and GTP nucleotides. The cycling between an inactive, GDP-bound state and an active, GTP-bound state is regulated by guanine nucleotide exchange factors and GTPase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edc2bf9f5eaaee0e6267bc23d0828a5f
https://doi.org/10.1007/s12104-019-09882-1
https://doi.org/10.1007/s12104-019-09882-1
Autor:
Dylan T. Stiles, Keith Robison, Alan S. Mann, Brian R. Bowman, Tara Hardy, Michelle L. Stewart, Siavash Mostafavi, Gregory L. Verdine, Seung-Joo Lee, Morgenstern Jay P, Zhigang Weng, Mathew E. Sowa, Sukrat Arya, Andrew M. Fry, Kyle Kenyon, Ende Pan, Richard D. Klausner, Khian Hong Pua, Roy M. Pollock, Sharon A. Townson, Minyun Zhou, Uddhav Kumar Shigdel, Andrew T Rajczewski, Joshua A. V. Blodgett, Daniel W. Udwary, Daniel C. Gray
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 29
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance This manuscript reports on a member of the FK506/rapamycin family, WDB002, and the realization that FKBP-mediated recognition is a genetically programmable modality that enables engagement of topologically flat targets. FKBP-mediated rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ebc35e6171956666cc689edb272560
https://escholarship.org/uc/item/96w4n83f
https://escholarship.org/uc/item/96w4n83f
Publikováno v:
Biomolecular NMR Assignments. 12:269-272
K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by guanine nucleotide exchange factors and GTPase act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e9239e062c7e5c2867c4b8a2c5fbd60
https://doi.org/10.1007/s12104-018-9821-8
https://doi.org/10.1007/s12104-018-9821-8
Autor:
Meizhong Jin, Linlong Xue, Sharon A. Townson, Alan C. Rigby, Siminia Grigoriu, Kathryn M. Luly, Earl W. May, Alex Yuzhakov, Cindy C. Benod, Michelle L. Stewart, Alan S. Mann, Mark J. Mulvihill, Anna Kohlmann, Nicholas Perl, Jason T. Lowe, Jonah Simon, Alec D Silver, Gregory L. Verdine, Roy M. Pollock, Minyun Zhou, Seung-Joo Lee
Publikováno v:
Molecular Cancer Research. 18:B37-B37
Activating mutations in RAS proteins occur in ~1/3 of human cancers. These mutations impair the ability of the protein to hydrolyze GTP to GDP. As a result, mutant RAS proteins exist predominantly in the GTP-bound state, which directly activates aber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706bd742386bb94e9909138f07069c19
https://doi.org/10.1158/1557-3125.ras18-b37
https://doi.org/10.1158/1557-3125.ras18-b37
Autor:
Earl W. May, Meizhong Jin, Gizem Akcay, Anna Kohlmann, Sharon A. Townson, Linlong Xue, Alexander Yuzhakov, Cindy C. Benod, Ganesh Iyer, Alec D Silver, Alan S. Mann, Nicholas Perl, Minyun Zhou
Publikováno v:
Molecular Cancer Research. 18:A06-A06
RAS proteins are small GTPases involved in cell proliferation, survival, and differentiation, and are mutationally activated in about a third of all human cancers. These mutations drive cancer by impairing GTPase activity so that the RAS protein is f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a684bd2145303e77787eba23f3670755
https://doi.org/10.1158/1557-3125.ras18-a06
https://doi.org/10.1158/1557-3125.ras18-a06
Publikováno v:
Biomolecular NMR assignments. 13(1)
K-Ras exists in two distinct structural conformations specific to binding of GDP and GTP nucleotides. The cycling between an inactive, GDP-bound state and an active, GTP-bound state is regulated by guanine nucleotide exchange factors and GTPase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0120dd70785e2314fdc6bb7ed0ed4339
https://pubmed.ncbi.nlm.nih.gov/30798456
https://pubmed.ncbi.nlm.nih.gov/30798456
Publikováno v:
Biomolecular Nmr Assignments
K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by guanine nucleotide exchange factors and GTPase act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fdddec5598c9f2e9495c8685ad652bd
https://pubmed.ncbi.nlm.nih.gov/29721757
https://pubmed.ncbi.nlm.nih.gov/29721757
Autor:
Gregory Zarbis-Papastoitsis, Allyson Masci, Christoph Thomas, Sharon A. Townson, Olga Kiner, Kathryn Golden, Jinzhao Hou, Joseph Kovalchin, Yanqun Shu, Emily Belcher Schirmer, Eric Furfine, K. Christopher Garcia, Thomas M. Barnes, Bracken M. King
Publikováno v:
Proceedings of the National Academy of Sciences. 110:3913-3918
IL-1 is a key inflammatory and immune mediator in many diseases, including dry-eye disease, and its inhibition is clinically efficacious in rheumatoid arthritis and cryopyrin-associated periodic syndromes. To treat ocular surface disease with a topic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a402ff48f7d311efbbe60a2d03ab1268
https://doi.org/10.1073/pnas.1217996110
https://doi.org/10.1073/pnas.1217996110
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex
Autor:
Jasbir Seehra, Katia Liharska, June Liu, Jeffrey A. Ucran, Patricia Lowden, Erik Martinez-Hackert, Kathryn W. Underwood, Sharon A. Townson, Chloe Greppi, Asya Grinberg, Ravindra Kumar, Sako Dianne S
Publikováno v:
Journal of Biological Chemistry. 287:27313-27325
Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β superfamily, is an important regulator of normal blood vessel development as well as pathological tumor angiogenesis. As such, ALK1 is an important ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1748287efd39885ad25e0e67b95c07e
https://doi.org/10.1074/jbc.m112.377960
https://doi.org/10.1074/jbc.m112.377960
High-Throughput, Cell-Free, Liposome-Based Approach for Assessing In Vitro Activity of Lipid Kinases
Autor:
Douglas J. Demian, Lucia E. Rameh, Deborah A. Sarkes, Meta M. Foster, Susan L. Clugston, Maura E. Charlton, Lily Yang, Sharon A. Townson, Melvin Zhang
Publikováno v:
SLAS Discovery. 14:838-844
Lipid kinases are central players in lipid signaling pathways involved in inflammation, tumorigenesis, and metabolic syndrome. A number of these kinase targets have proven difficult to investigate in higher throughput cell-free assay systems. This ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d307ba17d534980b6639dc830517f5a9
https://doi.org/10.1177/1087057109339205
https://doi.org/10.1177/1087057109339205