Výsledky vyhledávání - "Sharon A Sagan"

Akademický článek

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Autor: Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan

Publikováno v: eLife, Vol 5 (2016)

Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by si

Externí odkaz: https://doaj.org/article/4da806c40b4949a2851d1bc03be524f7

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Akademický článek

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.

Autor: Ulf Schulze-Topphoff, Aparna Shetty, Michel Varrin-Doyer, Nicolas Molnarfi, Sharon A Sagan, Raymond A Sobel, Patricia A Nelson, Scott S Zamvil

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33797 (2012)

Laquinimod is a novel oral drug that is currently being evaluated for the treatment of relapsing-remitting (RR) multiple sclerosis (MS). Using the animal model for multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), we examined how l

Externí odkaz: https://doaj.org/article/dab18e5d9e7142baac8776b4aae41eb4

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Akademický článek

Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function

Publikováno v: JCI Insight, Vol 7, Iss 4 (2022)

BACKGROUND Vaccine-elicited adaptive immunity is a prerequisite for control of SARS-CoV-2 infection. Multiple sclerosis (MS) disease-modifying therapies (DMTs) differentially target humoral and cellular immunity. A comprehensive comparison of the eff

Externí odkaz: https://doaj.org/article/fbe0d204af4d4ebaa9905f844ad5d93e

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ECTRIMS 2021 – Late Breaking News ePoster

Publikováno v: Multiple Sclerosis Journal. 27:752-804

Introduction: MS disease-modifying therapies (DMTs) lead to distinct effects on humoral and cellular immunity. Effective vaccine- elicited immunity to severe acute respiratory syndrome coronavirus- 2 (SARS-CoV-2), the causative agent of the ongoing C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd2dcb02546c486207b773d742da5a96
https://doi.org/10.1177/13524585211047080

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Longitudinal adaptive immune responses following sequential SARS-CoV-2 vaccinations in MS patients on anti-CD20 therapies and sphingosine-1-phosphate receptor modulators

Autor: Joseph J. Sabatino, Kristen Mittl, William Rowles, Colin R. Zamecnik, Rita P. Loudermilk, Chloe Gerungan, Collin M. Spencer, Sharon A. Sagan, Jessa Alexander, Kira Mcpolin, PeiXi Chen, Chinmay Deshpande, Kerri Wyse, Eric M. Maiese, Michael R. Wilson, Scott S. Zamvil, Riley Bove

Publikováno v: Multiple Sclerosis and Related Disorders. 70:104484

BackgroundAdequate response to the SARS-CoV-2 vaccine represents an important treatment goal in caring for patients with multiple sclerosis (MS) during the ongoing COVID-19 pandemic. Previous data so far have demonstrated lower spike-specific IgG res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15528018fa0ee3e92a721fd9a77a1c5
https://doi.org/10.1016/j.msard.2022.104484

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CAR-T Cell–Mediated B-Cell Depletion in Central Nervous System Autoimmunity

Autor: Sasha Gupta, Milos Simic, Sharon A. Sagan, Chanelle Shepherd, Jason Duecker, Raymond A. Sobel, Ravi Dandekar, Gregory F. Wu, Wesley Wu, John E. Pak, Stephen L. Hauser, Wendell Lim, Michael R. Wilson, Scott S. Zamvil

Publikováno v: Neurology - Neuroimmunology Neuroinflammation. 10:e200080

Background and ObjectivesAnti-CD20 monoclonal antibody (mAb) B-cell depletion is a remarkably successful multiple sclerosis (MS) treatment. Chimeric antigen receptor (CAR)-T cells, which target antigens in a non-major histocompatibility complex (MHC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf8a1e9b362c56735c94c614e97a1f91
https://doi.org/10.1212/nxi.0000000000200080

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Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity

Autor: Kristen Mittl, Jill A. Hollenbach, Joseph J. Sabatino, Kira Mcpolin, Danillo G. Augusto, Colin R. Zamecnik, Ravi Dandekar, Bonny D. Alvarenga, Chloe Gerungan, Scott S. Zamvil, Jessa Alexander, Collin M. Spencer, William Rowles, Riley Bove, Sharon A. Sagan, Jayant V. Rajan, Rita P. Loudermilk, Michael R. Wilson

Publikováno v: medRxiv
article-version (status) pre
article-version (number) 1

BACKGROUNDVaccine-elicited adaptive immunity is a prerequisite for control of SARS-CoV-2 infection. Multiple sclerosis (MS) disease-modifying therapies (DMTs) differentially target humoral and cellular immunity. A comprehensive comparison of the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e686d5c9edc793acd73d25fc3307f3f0
http://europepmc.org/articles/PMC8475959

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Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis

Autor: Tobias Sejbaek, Anna Bystrup, Frederik Novak, William Rowles, Kira Mcpolin, Sharon A. Sagan, Michael R. Wilson, Christian Nielsen, Joseph J. Sabatino, Kristen Mittl, Kamilla Østergaard, Anna Nilsson, Isik Somuncu Johansen, Chloe Gerungan, Scott S. Zamvil, Riley Bove, Keld-Erik Byg, Collin M. Spencer, Dorte Kinggaard Holm

Publikováno v: Novak, F, Nilsson, A C, Nielsen, C, Holm, D K, Østergaard, K, Bystrup, A, Byg, K E, Johansen, I S, Mittl, K, Rowles, W, Mcpolin, K, Spencer, C, Sagan, S, Gerungan, C, Wilson, M R, Zamvil, S S, Bove, R, Sabatino, J J & Sejbaek, T 2021, ' Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis ', Multiple Sclerosis and Related Disorders, vol. 56, 103251 . https://doi.org/10.1016/j.msard.2021.103251
Multiple Sclerosis and Related Disorders

Author(s): Novak, Frederik; Nilsson, Anna Christine; Nielsen, Christian; Holm, Dorte K; Ostergaard, Kamilla; Bystrup, Anna; Byg, Keld-Erik; Johansen, Isik S; Mittl, Kristen; Rowles, William; Mcpolin, Kira; Spencer, Collin; Sagan, Sharon; Gerungan, Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f6613bc28f0f885b895e2642fada52
https://doi.org/10.1016/j.msard.2021.103251

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Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

Autor: Andrés Cruz-Herranz, Michael J. Levy, Peggy P. Ho, Patricia A. Nelson, Marc H. Levin, Raymond A. Sobel, Mark S. Anderson, Lawrence Steinman, Jeffrey Bennett, Collin M. Spencer, Alan S. Verkman, Corey N. Miller, Ryan C. Winger, Scott S. Zamvil, Ari J. Green, Sarah Hagberg, Sharon A. Sagan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 51
Journal of nature and science, vol 3, iss 5

Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and exhibit Th17 polarization. However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c44b4bc005a99861cf4c3758f6a95c0
https://doi.org/10.1073/pnas.1617859114

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