Zobrazeno 1 - 10 of 257 pro vyhledávání: '"Sharon A McGrath-Morrow"'
1
Akademický článek
Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children
Autor: Jelte Kelchtermans, Michael E. March, Hakon Hakonarson, Sharon A. McGrath-Morrow
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Despite this, genetic drivers of BPD are poorly understood. The objective of this study is to better understand the impact of single nucleotide polymorphisms (SNPs)
Externí odkaz: https://doaj.org/article/137394040a2a435fbf0e536ee7114f81
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2
Akademický článek
Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia
Autor: Nigel S. Michki, Benjamin D. Singer, Javier V. Perez, Aaron J. Thomas, Valerie Natale, Kathryn A. Helmin, Jennifer Wright, Leon Cheng, Lisa R. Young, Howard M. Lederman, Sharon A. McGrath-Morrow
Publikováno v: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Introduction Ataxia telangiectasia (A-T) is an autosomal recessive neurodegenerative disease with widespread systemic manifestations and marked variability in clinical phenotypes. In this study, we sought to determine whether transcriptomic
Externí odkaz: https://doaj.org/article/7728c4ec26df47879e833f078300c83e
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3
Akademický článek
DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia
Autor: Nigel S. Michki, Roland Ndeh, Kathryn A. Helmin, Benjamin D. Singer, Sharon A. McGrath-Morrow
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Bacterial pulmonary infections are a major cause of morbidity and mortality in neonates, with less severity in older children. Previous studies demonstrated that the DNA of CD4+ T cells in the mouse lung, whose primary responsibility is to c
Externí odkaz: https://doaj.org/article/94fe431f22c34bdeb705ffc74f345c59
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4
Akademický článek
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
Autor: Sharon A McGrath-Morrow, Jarrett Venezia, Roland Ndeh, Nigel Michki, Javier Perez, Benjamin David Singer, Raffaello Cimbro, Mark Soloski, Alan L Scott
Publikováno v: eLife, Vol 12 (2023)
Bacterial pneumonia in neonates can cause significant morbidity and mortality when compared to other childhood age groups. To understand the immune mechanisms that underlie these age-related differences, we employed a mouse model of Escherichia coli
Externí odkaz: https://doaj.org/article/343c48856f7841dd96ed6d3039a518db
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5
Akademický článek
Growth in ataxia telangiectasia
Autor: Valerie A. I. Natale, Tim J. Cole, Cynthia Rothblum-Oviatt, Jennifer Wright, Thomas O. Crawford, Maureen A. Lefton-Greif, Sharon A. McGrath-Morrow, Haley Schlechter, Howard M. Lederman
Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Background Ataxia telangiectasia (A-T) is a DNA repair disorder that affects multiple body systems. Neurological problems and immunodeficiency are two important features of this disease. At this time, two main severity groups are defined in
Externí odkaz: https://doaj.org/article/f21ac658da604bb7a100f376a6f1d66d
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8
Akademický článek
Bronchopulmonary dysplasia: what are its links to COPD?
Autor: Sharon A. McGrath-Morrow, Joseph M. Collaco
Publikováno v: Therapeutic Advances in Respiratory Disease, Vol 13 (2019)
Emerging evidence suggests that adverse early life events can affect long-term health trajectories throughout life. Preterm birth, in particular, is a significant early life event that affects approximately 10% of live births. Worldwide, prematurity
Externí odkaz: https://doaj.org/article/28026329fdc84a209c0f61547c354cba
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