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Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 8(2)
cAMP phosphodiesterase (PDE) 4 is a family of enzymes the inhibition of which induces chronic lymphocytic leukemia (CLL) apoptosis. However, leukemic cells from a subset of CLL patients are relatively resistant to treatment with the PDE4 inhibitor ro