Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sharon, Rouw"'
Autor:
Sheri L. Bonar, Adam Libby, Yao Min, Richard Weier, Michael B. Tollefson, Serge G. Wolfson, Michael Clare, Ann M. Donnelly, William E. Mcghee, Dominique Bonafoux, Patrick J. Lennon, Sumathy Mathialagan, Julia A. Guzova, Nandini Kishore, Cindy Sommers, Sharon Rouw, Lori Christine, Catherine S. Tripp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2870-2875
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b9930690fa8fa16c025496d6ce863
https://doi.org/10.1016/j.bmcl.2005.03.090
https://doi.org/10.1016/j.bmcl.2005.03.090
Autor:
Sumathy Mathialagan, Hymavathi Boddupalli, Q. Khai Huynh, Sharon Rouw, Gary Lange, Troii Hall, David Creely, Rodney G. Combs, Catherine S. Tripp, Ann M. Donnelly, Kuniko Kretzmer, Beverley Reitz, James Caroll, Nandini Kishore
Publikováno v:
Journal of Biological Chemistry. 277:13840-13847
NF-kappaB is sequestered in the cytoplasm by the inhibitory IkappaB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IkappaBs leading to their degradation that results in NF-kappaB activation. IKK-1 and IKK-2 are two d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e2af8226f4a10b1f6807157139c867
https://doi.org/10.1074/jbc.m110474200
https://doi.org/10.1074/jbc.m110474200
Autor:
Cansu Tunca, Xiao Hu, Sarah Du, Elizabeth G. Webb, Susan Hummert, Jessica D. Dietz, Jamie Lee, Timothy Braden, Sharon Rouw, R. Keith Webber, Shridhar Hegde, Kelly R. Long, Mark Gerard Obukowicz
Publikováno v:
Endocrinology. 152(8)
A synthetic glucocorticoid receptor (GR) ligand with the efficacy of a glucocorticoid, but without the accompanying side effects, would meet an unmet medical need for the treatment of inflammatory diseases. It was hypothesized that a GR ligand that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c5449cd13422d008ef4407c998eb9a
https://pubmed.ncbi.nlm.nih.gov/21785014
https://pubmed.ncbi.nlm.nih.gov/21785014
Autor:
Mary W. Burney, Ted Baginski, Fei Shih, Stephen R. Rapp, Holly Meade, Kimberly Shevlin, Dean Welsch, Mike Baratta, Deborah Knoerzer, Sharon Rouw
Publikováno v:
D61. ANIMAL MODELS OF PULMONARY ARTERIAL HYPERTENSION: NEW IDEAS AND INSIGHTS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5414e4bc5fd49777a15cc7eedb5c7bb4
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6308
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6308
Autor:
Dean Welsch, Mary W. Burney, Stephen R. Rapp, Deborah Knoerzer, Ted Baginski, Kimberly Wade, Connie Fan, Joe Palandra, Karen Regina, Fei Shih, Sharon Rouw
Publikováno v:
A58. ANIMAL MODELS OF PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5d57f0fdf5727927767ec8af8d8795
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2000
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2000
Autor:
Ted Baginski, Connie Fan, Fei Shih, Deborah Knoerzer, Stephen R. Rapp, Karen Regina, Sharon Rouw, Kimberly Wade, Mary W. Burney, Dean Welsch
Publikováno v:
A58. ANIMAL MODELS OF PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89021b31f353c924ac942bbb33e58b08
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2001
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2001
Autor:
Sharon Rouw, Adam Libby, Michael Clare, Horng-Chih Huang, Cynthia D. Sommers, Julia A. Guzova, Nandidni N. Kishore, Richard Weier, Sheri L. Bonar, Sumathy Mathialagan, Lori J. Vanella, Dominique Bonafoux, Jeanette L. Glaenzer, Koszyk Francis, Ann M. Donnelly, He Huang, David S. Oburn, Patrick J. Lennon, Catherine S. Tripp, Serge G. Wolfson
Publikováno v:
Bioorganicmedicinal chemistry. 18(1)
Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1beta stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c76055db0ef28806da346227b07a394
https://pubmed.ncbi.nlm.nih.gov/19914076
https://pubmed.ncbi.nlm.nih.gov/19914076
Autor:
Nandini, Kishore, Q Khai, Huynh, Sumathy, Mathialagan, Troii, Hall, Sharon, Rouw, David, Creely, Gary, Lange, James, Caroll, Beverley, Reitz, Ann, Donnelly, Hymavathi, Boddupalli, Rodney G, Combs, Kuniko, Kretzmer, Catherine S, Tripp
Publikováno v:
The Journal of biological chemistry. 277(16)
NF-kappaB is sequestered in the cytoplasm by the inhibitory IkappaB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IkappaBs leading to their degradation that results in NF-kappaB activation. IKK-1 and IKK-2 are two d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa6a95c23e5f054e1f97bbcd2ed5b370
https://pubmed.ncbi.nlm.nih.gov/11839743
https://pubmed.ncbi.nlm.nih.gov/11839743