Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sharon, McGonigle"'
Autor:
Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging a
Externí odkaz:
https://doaj.org/article/0260063af8414162a61d45c6971191f1
Autor:
Jessica F, Boehler, Kristy J, Brown, Margaret, Beatka, J Patrick, Gonzalez, Roxana, Donisa Dreghici, Meghan, Soustek-Kramer, Sharon, McGonigle, Annie, Ganot, Timothy, Palmer, Caitlin, Lowie, Jeffrey S, Chamberlain, Michael W, Lawlor, Carl A, Morris
Publikováno v:
Neuromuscular Disorders. 33:40-49
Accelerated approval based on a likely surrogate endpoint can be life-changing for patients suffering from a rare progressive disease with unmet medical need, as it substantially hastens access to potentially lifesaving therapies. In one such example
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae84146b67be7581f1dbbb80f22975d3
https://doi.org/10.1016/j.nmd.2022.12.007
https://doi.org/10.1016/j.nmd.2022.12.007
Autor:
Nicola Cresti, Marie Foegh, Mark Matijevic, Divyanshu Dua, Peter Stephens, Yvette Drew, Pallavi Sachdev, Sharon McGonigle, Ruth Plummer, Debashis Sarker, Nancy Hall, Steen Knudsen, Vaishali Dixit, Shannon McGrath, Bipin Mistry
Publikováno v:
British Journal of Cancer
BackgroundThis phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor.MethodsE7449 was orally administered once daily in 28-day cycles to patients with advanced s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c229e23eeddc49ee113a9af76c5a8fdd
https://pubmed.ncbi.nlm.nih.gov/32523090
https://pubmed.ncbi.nlm.nih.gov/32523090
Autor:
Makoto Asano, Junji Matsui, Kenichi Nomoto, Murray J. Towle, Sharon McGonigle, Toshimitsu Uenaka, Bruce A. Littlefield, Marc Hillairet De Boisferon, Jiayi Wu
Publikováno v:
Anticancer research. 38(6)
Background Eribulin is used in many countries to treat patients with advanced breast cancer or liposarcoma and exerts in vivo anticancer activity under monotherapy conditions against various human tumor xenograft models. Here, eribulin in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a846b04502322baf15ba8196153ecb3b
https://pubmed.ncbi.nlm.nih.gov/29848686
https://pubmed.ncbi.nlm.nih.gov/29848686
Autor:
Kenichi Nomoto, Kuan-Chun Huang, Donna Kolber-Simonds, Natalie C. Twine, George A. Moniz, Paul Chang, Jue-lon Shie, Jingzang Tao Miu, Karen Ackermann, Zhihong Chen, Sharon McGonigle, Jiayi Wu
Publikováno v:
Oncotarget
Impact Journals/National Center for Biotechnology Information (U.S.)
Impact Journals/National Center for Biotechnology Information (U.S.)
Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. Here, we describe the development of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e06e5b24d95dc69ae605cc8d13662cf
https://doi.org/10.18632/oncotarget.5846
https://doi.org/10.18632/oncotarget.5846
Autor:
Maarten H. D. Postema, Donna Kolber-Simonds, Daniel W. Custar, Thomas Noland, Kenichi Nomoto, Jiayi Wu, Vaishali Dixit, Danyang Li, W. George Lai, Karen TenDyke, Utpal Majumder, Hong Du, Sean Eckley, Sharon McGonigle, Mary Woodall-Jappe, Andrew Hart
Publikováno v:
Cancer Research. 78:3961-3961
Chlorotoxin is an established tumor targeting peptide that naturally occurs in scorpion venom. 131I-labelled chlorotoxin assessed in early phase human glioma clinical trials achieved promising results. A peptide drug conjugate (PDC) composed of chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349ca6abb00fabdde005013a9d18f274
https://doi.org/10.1158/1538-7445.am2018-3961
https://doi.org/10.1158/1538-7445.am2018-3961
Autor:
Debashis Sarker, Aneta Suder, Peter Stephens, Steen Knudsen, Elizabeth Ruth Plummer, Nicola Cresti, Sharon McGonigle, Yvette Drew, Barbara Ink, Marie Foegh, Divyanshu Dua
Publikováno v:
Journal of Clinical Oncology. 36:2505-2505
2505Background: A phase I study was done to establish the safety, MTD and anti-tumour efficacy of the novel PARP 1/2 and Tankyrase 1/2 inhibitor, 2X-121 (E7449). A novel tumor agnostic molecular bi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6920391cc63867dbda58ba69a43cbe8
https://doi.org/10.1200/jco.2018.36.15_suppl.2505
https://doi.org/10.1200/jco.2018.36.15_suppl.2505
Autor:
Olivia Saqui, Sharon McGonigle, Lydia Fairholm, M. Yeung, Albert Chang, Brendan Purdy, Johane P. Allard, Peter G. Rossos, Mary Baun
Publikováno v:
Journal of Parenteral and Enteral Nutrition. 31:234-239
Telehealth videoconferencing is a medium for health care professionals to communicate and care for patients living in remote areas. The aim of this study was to provide a survey to examine management outcome of home parenteral nutrition (HPN) patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2980a9e8da823ce91616774dce117f72
https://doi.org/10.1177/0148607107031003234
https://doi.org/10.1177/0148607107031003234
Publikováno v:
Biochemistry. 41:579-587
Schistosoma mansoni receptor kinase 1 (SmRK1) is a divergent member of the TGFβ receptor family. Intracellular proteins that associate with these receptors are likely to play an important role in s...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::383a31a153903c2216ca7c95da8fd62c
https://doi.org/10.1021/bi011407z
https://doi.org/10.1021/bi011407z
Publikováno v:
Molecular and Biochemical Parasitology. 114:119-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c006b0bf420a0bac52c8a8547e6771
https://doi.org/10.1016/s0166-6851(01)00232-8
https://doi.org/10.1016/s0166-6851(01)00232-8