Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Sharon, Gowan"'
Autor:
Afia Naseem, Akos Pal, Sharon Gowan, Yasmin Asad, Adam Donovan, Csilla Temesszentandrási-Ambrus, Emese Kis, Zsuzsanna Gaborik, Gurdip Bhalay, Florence Raynaud
Publikováno v:
Cells, Vol 11, Iss 20, p 3286 (2022)
Caco-2 screens are routinely used in laboratories to measure the permeability of compounds and can identify substrates of efflux transporters. In this study, we hypothesized that efflux transporter inhibition of a compound can be predicted by an intr
Externí odkaz:
https://doaj.org/article/607381ec02564b09b33df71ee4a144ba
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Autor:
Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 66:5892-5906
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9094aa8cbb7b8cceb3273b677e3d3d9
https://doi.org/10.1021/acs.jmedchem.3c00155
https://doi.org/10.1021/acs.jmedchem.3c00155
Autor:
A. Elisa Pasqua, Swee Y. Sharp, Nicola E. A. Chessum, Angela Hayes, Loredana Pellegrino, Michael J. Tucker, Asadh Miah, Birgit Wilding, Lindsay E. Evans, Carl S. Rye, N. Yi Mok, Manjuan Liu, Alan T. Henley, Sharon Gowan, Emmanuel De Billy, Robert te Poele, Marissa Powers, Suzanne A. Eccles, Paul A. Clarke, Florence I. Raynaud, Paul Workman, Keith Jones, Matthew D. Cheeseman
Publikováno v:
Journal of Medicinal Chemistry. 66:5907-5936
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719374538241e3474602d329b097d75c
https://doi.org/10.1021/acs.jmedchem.3c00156
https://doi.org/10.1021/acs.jmedchem.3c00156
Autor:
Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. de Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby de Klerk, Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 65:8191-8207
The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69d8cef8cdf04211cefb44860e5b55b
https://doi.org/10.1021/acs.jmedchem.1c02175
https://doi.org/10.1021/acs.jmedchem.1c02175
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Pediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640aae47942f24340443cc8cc3e198f2
https://doi.org/10.1158/1535-7163.c.6535482
https://doi.org/10.1158/1535-7163.c.6535482
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 3 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ea1a0d2375245f2f675778fbd807ca
https://doi.org/10.1158/1535-7163.22497045
https://doi.org/10.1158/1535-7163.22497045
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 1 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e2e83c50e82bfdffe58fedf9bc1cf
https://doi.org/10.1158/1535-7163.22497051
https://doi.org/10.1158/1535-7163.22497051
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 2 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36acbf2d62a640c492d6925e4c982075
https://doi.org/10.1158/1535-7163.22497048
https://doi.org/10.1158/1535-7163.22497048
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 4 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f3d979d3f73f11e6aadf88a7c1e75a
https://doi.org/10.1158/1535-7163.22497042.v1
https://doi.org/10.1158/1535-7163.22497042.v1
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure Legends 1-4 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e605df45e48e879d336038740a6233d
https://doi.org/10.1158/1535-7163.22497039
https://doi.org/10.1158/1535-7163.22497039