Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sharmila Adhikari"'
Autor:
Natalie Roy D’Amore, Shih-Chung Huang, Sharmila Adhikari, Dylan England, David Lok, Anna Lublinsky, Jouhara Chouitar, Klaudia Foley, Patrick J. LeRoy, Emily F. Calderwood, Ji Zhang, Alexandra E. Gould, James E. Brownell, Sean J. Harrison, Li-Ting Ma, Yu Yang, Saurabh Menon
Publikováno v:
Bioorganicmedicinal chemistry. 28(19)
Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describe
Autor:
Mi-Sook Kim, Mansoureh Rezaei, Jouhara Chouitar, Katherine Brewer, Michael D. Smith, Alexandra E. Gould, Katherine Galvin, Shih-Chung Huang, Dong Mei Zhang, Sharmila Adhikari, Hirotake Mizutani, Steven P. Langston, Dylan England, Paul D. Greenspan, Emily F. Calderwood, Craig Fisher, Sean J. Harrison, Li-Ting Ma, Saurabh Menon, Roushan Afroze, Jeffery Gaulin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1156-1160
Investigations of a biaryl ether scaffold identified tetrahydronaphthalene Raf inhibitors with good in vivo activity; however these compounds had affinity toward the hERG potassium channel. Herein we describe our work to eliminate this hERG activity
Autor:
Sharmila Adhikari
Publikováno v:
SMART MOVES JOURNAL IJELLH. 8:13
The representation of human body in popular culture has always been a matter of controversy. This controversy applied and still applies in women's body, particularly in commercials. The feminist critics accuse that women are objectified in the popula
Autor:
Wai Heng Lua, Lai Ling Liew, Frank Eisenhaber, Manfred Koranda, Weimiao Yu, Hwee Kuan Lee, Wolfgang Benetka, Birgit Eisenhaber, Michaela Sammer, Sharmila Adhikari
Publikováno v:
Cell Cycle. 10:3897-3911
Lipid-modified transcription factors (TFs) are biomolecular oddities, since their reduced mobility and membrane attachment appear to contradict nuclear import required for their gene-regulatory function. NFAT5 isoform a (selected from an in silico sc
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat
Autor:
Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston
Publikováno v:
Nature. 458:732-736
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) i
Publikováno v:
Shock. 31:33-39
Fractalkine (FTK) is a unique member of the CX3C chemokine family by acting through the CX3CR1 receptor. Membrane-bound FTK acts like an adhesion molecule, whereas soluble FTK (sFTK) acts as a classic chemokine ligand. Whether this chemokine plays a
Autor:
Madhav Bhatia, Sharmila Adhikari
Publikováno v:
Journal of Cellular and Molecular Medicine
Treatment of pancreatic acinar cells by hydrogen sulphide has been shown to induce apoptosis. However, a potential role of mitogen-activated protein kinases (MAPKs) in this apoptotic pathway remains unknown. The present study examined the role of MAP
Publikováno v:
The Journal of Immunology. 179:4153-4160
Hydrogen sulfide (H2S) has been shown to induce the activation of neurogenic inflammation especially in normal airways and urinary bladder. However, whether endogenous H2S would regulate sepsis-associated lung inflammation via substance P (SP) and it
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 67(Pt 8)
The transfer of glycosylphosphatidylinositol (GPI) anchors onto eukaryotic proteins is catalyzed by the transamidase complex, which is composed of at least five subunits (PIG-K, PIG-S, PIG-T, PIG-U and GPAA1). Here, the recombinant protein PIG-S(71-4