Výsledky vyhledávání - "Sharmada Swaminath"

Akademický článek

Maximal interferon induction by influenza lacking NS1 is infrequent owing to requirements for replication and export.

Autor: Alison C Vicary, Marisa Mendes, Sharmada Swaminath, Asama Lekbua, Jack Reddan, Zaida K Rodriguez, Alistair B Russell

Publikováno v: PLoS Pathogens, Vol 19, Iss 4, p e1010943 (2023)

Influenza A virus exhibits high rates of replicative failure due to a variety of genetic defects. Most influenza virions cannot, when acting as individual particles, complete the entire viral life cycle. Nevertheless influenza is incredibly successfu

Externí odkaz: https://doaj.org/article/f3fa9eb1dcec41b8a6125f4efd0ee5bc

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Akademický článek

Growth and division mechanisms by which genetic resisters emerge from the rifampicin-surviving population of differentially antibiotic-susceptible mycobacterial subpopulations

Autor: Kishor Jakkala, Avraneel Paul, Rashmi Ravindran Nair, Sharmada Swaminath, Atul Pradhan, Parthasarathi Ajitkumar

Publikováno v: International Journal of Mycobacteriology, Vol 11, Iss 3, Pp 273-286 (2022)

Background: We recently reported the de novo emergence of unusually high numbers of antibiotic resisters from the in vitro cultures of Mycobacterium tuberculosis and Mycobacterium smegmatis surviving in the presence of minimum bactericidal concentrat

Externí odkaz: https://doaj.org/article/b14cc35d48c4495f947eb745ef2a7762

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Akademický článek

Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of Mycobacterium smegmatis globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation

Autor: Sharmada Swaminath, Atul Pradhan, Rashmi Ravindran Nair, Parthasarathi Ajitkumar

Publikováno v: Current Research in Microbial Sciences, Vol 3, Iss , Pp 100142- (2022)

The physiological role of mono-ADP-ribosyl transferase (Arr) of Mycobacterium smegmatis, which inactivates rifampicin, remains unclear. An earlier study reported increased expression of arr during oxidative stress and DNA damage. This suggested a rol

Externí odkaz: https://doaj.org/article/74f1fea85bd24cbf8d06eac26a5201cd

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Akademický článek

Mycobacterium tuberculosis Cells Surviving in the Continued Presence of Bactericidal Concentrations of Rifampicin in vitro Develop Negatively Charged Thickened Capsular Outer Layer That Restricts Permeability to the Antibiotic

Autor: Jees Sebastian, Rashmi Ravindran Nair, Sharmada Swaminath, Parthasarathi Ajitkumar

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Majority of the cells in the bacterial populations exposed to lethal concentrations of antibiotics for prolonged duration succumbs to the antibiotics’ sterilizing activity. The remaining cells survive by diverse mechanisms that include reduced perm

Externí odkaz: https://doaj.org/article/ee833c5225344c14a0e6e00b787e30e5

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Akademický článek

Unique Mode of Cell Division by the Mycobacterial Genetic Resister Clones Emerging De Novo from the Antibiotic-Surviving Population

Autor: Kishor Jakkala, Avraneel Paul, Atul Pradhan, Rashmi Ravindran Nair, Deepti Sharan, Sharmada Swaminath, Parthasarathi Ajitkumar

Publikováno v: mSphere, Vol 5, Iss 6 (2020)

ABSTRACT The emergence of antibiotic genetic resisters of pathogenic bacteria poses a major public health challenge. The mechanism by which bacterial antibiotic genetic resister clones formed de novo multiply and establish a resister population remai

Externí odkaz: https://doaj.org/article/c0074690c9f24c92929f11a46150eaae

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Maximal interferon induction by influenza lacking NS1 is infrequent owing to requirements for replication and export

Autor: Alison C. Vicary, Marisa Mendes, Sharmada Swaminath, Asama Lekbua, Jack Reddan, Zaida K. Rodriguez, Alistair B. Russell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497a6998d5b34e3c1c8a0d0e413f4377
https://doi.org/10.1101/2022.10.24.513459

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Mycobacterium smegmatis moxifloxacin persister cells produce high levels of hydroxyl radical, generating genetic resisters selectable not only with moxifloxacin, but also with ethambutol and isoniazid

Autor: Sharmada Swaminath, Avraneel Paul, Parthasarathi Ajitkumar, Jees Sebastian, Rashmi Ravindran Nair, Atul Pradhan

Publikováno v: Microbiology. 166:180-198

Bacterial antibiotic persister cells tolerate lethal concentrations of antibiotics but emerge as the antibiotic-sensitive population upon antibiotics withdrawal. However, the possibility of antibiotic-resistant genetic mutants emerging from the antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd6a7092a79c8c79c11722bfc5a6d91e
https://doi.org/10.1099/mic.0.000874

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A method for the enrichment, isolation and validation of Mycobacterium smegmatis population surviving in the presence of bactericidal concentrations of rifampicin and moxifloxacin

Autor: Parthasarathi Ajitkumar, Sharmada Swaminath, Kishor Jakkala, Atul Pradhan

Publikováno v: FEMS Microbiology Letters. 368

The bacterial populations surviving in the presence of antibiotics contain cells that have gained genetic resistance, phenotypic resistance and tolerance to antibiotics. Isolation of live bacterial population, surviving against antibiotics, from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf137ba7565350cec244aa2a5a29e541
https://doi.org/10.1093/femsle/fnab090

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