Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Sharlyn J. Mazur"'
Autor:
Kate Brown, Lisa M. Miller Jenkins, Daniel R. Crooks, Deborah R. Surman, Sharlyn J. Mazur, Yuan Xu, Bhargav S. Arimilli, Ye Yang, Andrew N. Lane, Teresa W-M. Fan, David S. Schrump, W. Marston Linehan, R. Taylor Ripley, Ettore Appella
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
TP53 is the most commonly mutated gene in cancer, and gain-of-function mutations have wide-ranging effects. Efforts to reactivate wild-type p53 function and inhibit mutant functions have been complicated by the variety of TP53 mutations. Identified f
Externí odkaz:
https://doaj.org/article/c07b755597a5468588906ab014a43c40
Autor:
Burhan Uyanik, Anastasia R. Goloudina, Aamir Akbarali, Bogdan B. Grigorash, Alexey V. Petukhov, Sunil Singhal, Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette, Tarik Hadi, Ekaterina V. Baidyuk, Hiroyasu Sakai, Lino Tessarollo, Bernhard Ryffel, Sharlyn J. Mazur, Frederic Lirussi, Carmen Garrido, Ettore Appella, Oleg N. Demidov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune r
Externí odkaz:
https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8
Autor:
Tarik Hadi, Frédéric Lirussi, Lisa Lagorgette, Aamir Akbarali, Evgeniy Eruslanov, Bernhard Ryffel, Ettore Appella, Alexey Petukhov, Jeanne Chaloyard, Sharlyn J. Mazur, Oleg N. Demidov, Sunil Singhal, Bogdan B. Grigorash, E. V. Baidyuk, Hiroyasu Sakai, Burhan Uyanik, Anastasia R. Goloudina, Carmen Garrido, Lino Tessarollo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we sho
Autor:
Marco Robello, Hongchao Zheng, Mrinmoy Saha, Kara M. George Rosenker, Subrata Debnath, Jay Prakash Kumar, Harichandra D. Tagad, Sharlyn J. Mazur, Ettore Appella, Daniel H. Appella
Publikováno v:
European journal of medicinal chemistry. 243
The wild-type p53 induced phosphatase 1 (Wip1), a member of the serine/threonine-specific PP2C family, is overexpressed in numerous human cancers. Wip1 dephosphorylates p53 as well as several kinases (such as p38 MAPK, ATM, Chk1, and Chk2) in the DNA
Autor:
Sharlyn J. Mazur, Olga Vasalatiy, Dingyin Tao, Daniel H. Appella, Subrata Debnath, Yuhong Wang, Rebecca Eells, Harichandra D. Tagad, Mark J. Henderson, Victor Clausse, Kelly Lane, Nathan P. Coussens, Christopher A. LeClair, Zhen-Dan Shi, Martin R. Webb, Min Shen, Yuhong Fang, Lynn K. Baker, Matthew D. Hall, Hongmao Sun, Ettore Appella
Publikováno v:
The Journal of Biological Chemistry
Wildtype P53-induced phosphatase 1 (WIP1) is a member of the magnesium-dependent serine/threonine protein phosphatase (PPM) family and is induced by P53 in response to DNA damage. In several human cancers, the WIP1 protein is overexpressed, which is
Autor:
Fred Dyda, Harichandra D. Tagad, Roderico Acevedo, Dalibor Kosek, Daniel H. Appella, Subrata Debnath, Alexander Grishaev, Stewart R. Durell, Ettore Appella, Sharlyn J. Mazur
Publikováno v:
Journal of Biological Chemistry. 293:7993-8008
Metal-dependent protein phosphatases (PPM) are evolutionarily unrelated to other serine/threonine protein phosphatases and are characterized by their requirement for supplementation with millimolar concentrations of Mg(2+) or Mn(2+) ions for activity
Autor:
Subrata Debnath, Ettore Appella, Sharlyn J. Mazur, Harichandra D. Tagad, Victor Clausse, Daniel H. Appella, Mrinmoy Saha
Publikováno v:
ChemMedChem
The wild-type p53 induced phosphatase 1, Wip1 (PP2Cδ), is a protein phosphatase 2C (PP2C) family serine/threonine phosphatase that negatively regulates the function of the tumor suppressor p53 and several of its positive regulators such as ATM, Chk1
Autor:
Kyle Anderson, Ettore Appella, Subrata Debnath, Elyssia S. Gallagher, Jeffrey W. Hudgens, Sharlyn J. Mazur, Stewart R. Durell, Lisa M. Miller Jenkins
Publikováno v:
Biochemistry. 56:2676-2689
PPM serine/threonine protein phosphatases function in signaling pathways and require millimolar concentrations of Mn2+ or Mg2+ ions for activity. Whereas the crystal structure of human PP2Cα displayed two tightly bound Mn2+ ions in the active site,
Autor:
Daniel P. Weber, Sharlyn J. Mazur
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:978-981
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) provides information about protein conformational mobility under native conditions. The area between exchange curves, A bec , a functional data analysis concept, was adapted to the interpretation
Autor:
Giuseppe Giannini, Ying Hu, Carol J. Thiele, Jian Jin, Zhihui Liu, Ettore Appella, Chunhua Yan, Sharlyn J. Mazur, Bárbara Kunzler Souza, Veronica Veschi, Laurent Ozbun, Javed Khan, Norris Lam, Anqi Ma, Cheryl H. Arrowsmith, Gordon L. Hager, Ty C. Voss, Berkley E. Gryder
Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774daa5664f2503097fffeaef6bbd43
http://hdl.handle.net/11573/927636
http://hdl.handle.net/11573/927636