Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sharlene R. Lim"'
Publikováno v:
BioTechniques, Vol 42, Iss 4, Pp 467-472 (2007)
A systems approach is being applied in many areas of the biological sciences, particularly in cancer research. The coordinated, simultaneous extraction of DNA, RNA, and proteins from a single sample is crucial for accurate correlations between genomi
Externí odkaz:
https://doaj.org/article/55cb1b4f62eb45b885b9ebc503e01e50
Autor:
Jin Hong, John B. Nicholas, Sharlene R. Lim, Eva Herrmann, Karl Kossen, Scott D. Seiwert, Xiaoli Qin, Patrick F. Smith, Bradford Williamson Ziegler, Christophe Sarrazin, Stefan Zeuzem, Isabel Najera, Ann Arfsten, Simone Susser, Christian M. Lange, Lisa Hooi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:271-279
Danoprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor that promotes multi-log 10 reductions in HCV RNA when administered as a 14-day monotherapy to patients with genotype 1 chronic HCV. Of these patients, 14/37 experienced a continuous de
Autor:
Karl Kossen, Scott D. Seiwert, Sharlene R. Lim, Caralee J. Schaefer, Jiing-Huey Lin, Patrick F. Smith, Lin Pan, Bradford Williamson Ziegler
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:3125-3132
Danoprevir is a potent and selective direct-acting antiviral agent that targets the protease activity of hepatitis C virus (HCV) NS3/4A. This agent results in a significant rapid decline in HCV RNA levels when it is used in monotherapy. The present s
Autor:
Jin Hong, Christine Lemieux, Scott D. Seiwert, Shawn Misialek, Robert Rieger, Dylan P. Hartley, Lawrence M. Blatt, Sharlene R. Lim, Kevin Ronald Condroski, Antitsa Dimitrova Stoycheva, Lin Pan, Hua Tan, Gary P. Hingorani, Leonid Beigelman, Hailong Zhang, John A. Josey, Xiaoli Qin, Karl Kossen, P. T. Ravi Rajagopalan, Mary Geck Do, Vladimir Serebryany, Sarah K. Stevens, Andrews Steven W, Jiang Yutong
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4432-4441
Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor of the NS3/4A protease of HCV, are descr
Autor:
Sharlene R. Lim, Klemens J. Hertel
Publikováno v:
Molecular Cell. 15:477-483
Differential recognition of exons by the spliceosome regulates gene expression and exponentially increases the complexity of metazoan proteomes. After definition of the exons, the spliceosome is activated by a series of sequential structural rearrang
Publikováno v:
C71. MAJOR IMPACT OF MICRO-RNA FUNCTION.
Publikováno v:
BioTechniques. 42(4)
A systems approach is being applied in many areas of the biological sciences, particularly in cancer research. The coordinated, simultaneous extraction of DNA, RNA, and proteins from a single sample is crucial for accurate correlations between genomi
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 12(6)
Mutations in one of the duplicated survival of motor neuron (SMN) genes lead to the progressive loss of motor neurons and subsequent development of spinal muscular atrophy (SMA), a common, and usually fatal, hereditary disease. Homozygous absence of
Autor:
Sharlene R. Lim, Klemens J. Hertel
Publikováno v:
The Journal of biological chemistry. 276(48)
Spinal muscular atrophy is caused by the loss of functional survival motor neuron (SMN1) alleles. A translationally silent nucleotide transition in the duplicated copy of the gene (SMN2) leads to exon 7 skipping and expression of a nonfunctional gene