Výsledky vyhledávání - "Sharlene L Pereira"

Beneficial effects of a novel agonist of the adenosine A2Areceptor on monocrotaline-induced pulmonary hypertension in rats

Autor: Allan K Alencar, Tadeu L Montagnoli, Sharon S. Landgraf, Gisele Zapata-Sudo, Celso Caruso-Neves, Sharlene L Pereira, José Nascimento, Carlos Mauricio R. Sant'Anna, Roberto T. Sudo, Carlos A. M. Fraga, Arthur Eugen Kümmerle, Roberta Tesch, Eliezer J. Barreiro, Rodolfo C. Maia, Emanuelle B. Ferraz

Publikováno v: British Journal of Pharmacology. 169:953-962

Background and Purpose Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, right ventricular hypertrophy and increased right ventricular systolic pressure. Here, we investigated the effects of a N-acylhyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::908e5ebd4a669957d2bc096772dc7a88
https://doi.org/10.1111/bph.12193

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A novel Ca²+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension

Autor: Roberto T. Sudo, Carlos A. M. Fraga, Emanuelle B. Ferraz, Nazareth N. Rocha, Gisele Zapata-Sudo, Eliezer J. Barreiro, Arthur Eugen Kümmerle, Sharlene L Pereira, José Nascimento

Publikováno v: European Journal of Pharmacology. 702:316-322

This work investigates the actions of LASSBio-1289, (E)-N-methyl-N'-(thiophen-3-methylene)benzo[d][1,3]dioxole-5-carbohydrazide, on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. Two weeks following the MCT injection, LASS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79b1f226f5d7a0b7596506a6e6fe6234
https://doi.org/10.1016/j.ejphar.2013.01.050

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Docking, Synthesis and Anti-Diabetic Activity of Novel Sulfonylhydrazone Derivatives Designed as PPAR-Gamma Agonists

Autor: Eliezer J. Barreiro, Nelilma C. Romeiro, Lídia Moreira Lima, Roberto T. Sudo, Margarete M. Trachez, Everton D. D’Andrea, Filipe P. da Costa, Gisele Zapata-Sudo, Beatriz J. Souza, Carlos Eduardo da Silva Monteiro, Sharlene L Pereira

Publikováno v: Current Topics in Medicinal Chemistry. 12:2037-2048

Diabetes is a metabolic disorder characterized by hyperglycemia. When not properly controlled, complications include neuropathy, coronary artery disease, and renal failure. Several drugs are approved for diabetes treatment; however their use is assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9087bd7e635a29910ad5ca974b5c3f55
https://doi.org/10.2174/156802612804910205

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Vasodilator and antihypertensive effects of a novelN-acylhydrazone derivative mediated by the inhibition of L-type Ca2+channels

Autor: Roberto T. Sudo, Carlos A. M. Fraga, Eliezer J. Barreiro, Gisele Zapata-Sudo, Arthur Eugen Kümmerle, Sharlene L Pereira

Publikováno v: Fundamental & Clinical Pharmacology. 28:29-41

New bioactive N-acylhydrazone derivatives synthesized from safrole previously have been found to promote intense vasodilation and antihypertensive activity. In this study, we describe the synthesis and the cardiovascular effects of the new N-acylhydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7389559336da72e5b9f92d24aee0d053
https://doi.org/10.1111/j.1472-8206.2012.01076.x

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N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity

Autor: Emanuelle B. Ferraz, Carlos A. M. Fraga, Luiza V.P. Mendes, Tadeu L Montagnoli, Celso Caruso-Neves, Roberta Tesch, Allan K Alencar, Flavia E. da Silva, Lídia Moreira Lima, Gisele Zapata-Sudo, Sharlene L Pereira, Roberto T. Sudo, Valéria M.N. Cunha, José Nascimento, Carlos Mauricio R. Sant'Anna, Eliezer J. Barreiro

Publikováno v: International journal of cardiology. 173(2)

Pulmonary arterial hypertension (PAH) is a disease that results in right ventricular (RV) dysfunction. While pulmonary vascular disease is the primary pathological focus, RV hypertrophy and RV dysfunction are the major determinants of prognosis in PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bbe18b68aa6d2c7fcb6e3cec0cef0b
https://pubmed.ncbi.nlm.nih.gov/24630383

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Hypoglycemic Effect of the Methanol flower Extract of Piper Claussenianum and the Major Constituent 2',6'-dihydroxy-4'-methoxychalcone in Streptozotocin Diabetic Rats

Autor: C. V. Cavalcante, Maria Auxiliadora Coelho Kaplan, André M. Marques, Gisele Zapata Sudo, Roberto T. Sudo, Luzineide W. Tinoco, Sharlene L Pereira, E. F. Guimaraes, S. Z. Sudo, Davyson de Lima Moreira, R. A. Paiva

Publikováno v: Indian Journal of Pharmaceutical Sciences

Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels of rats treated with methanol extract were reduced from 318.4±28.1 mg/dl before treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b88710d5c1117c0473ce86a6adda12
https://pubmed.ncbi.nlm.nih.gov/26009660

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Abstract 058: Novel Agonist of Adenosine Receptor Ameliorates Ventricular and Vascular Dysfunction in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats

Autor: Gisele Zapata-Sudo, Allan K Alencar, Sharlene L Pereira, Emanelle Ferraz, José H Nascimento, Roberta Tesch, Rodolfo Maia, Carlos M Sant’Anna, Carlos A Fraga, Eliezer J Barreiro, Roberto T Sudo

Publikováno v: Circulation Research. 113

Aims: Pulmonary arterial hypertension (PAH) consists of increased pulmonary vascular resistance and remodeling and right ventricular hypertrophy. This work investigated the effects of a new N -acylhydrazone derivative, (E)-N’-(3,4-dimethoxybenzylid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::385e6ac8d9cd457be4114fe7d50b9f84
https://doi.org/10.1161/res.113.suppl_1.a058

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Abstract 059: N-acylhydrazone Derivative Improves Cardiac Hypertrophy and Dysfunction in Spontaneously Hypertensive Rats Submitted to Myocardial Infarction

Autor: Gisele Zapata-Sudo, Jaqueline S Silva, Sharlene L Pereira, Rodolfo C Maia, Carlos A Fraga, Eliezer J Barreiro, Roberto T Sudo

Publikováno v: Circulation Research. 113

Aims: Ventricular dysfunction is observed in arterial hypertension and myocardial infarction (MI). The N -acylhydrazone derivative, 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294), which has been described as a potent cardiac inotropic age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8c213cc1bbfec916551b444c5f3ff61
https://doi.org/10.1161/res.113.suppl_1.a059

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N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle

Autor: Gisele Zapata-Sudo, Eliezer J. Barreiro, Sharon S. Landgraf, Rodolfo C. Maia, Arthur Eugen Kümmerle, Jaqueline S da Silva, Sharlene L Pereira, Roberto T. Sudo, Celso Caruso-Neves, Carlos A. M. Fraga

Publikováno v: Life sciences. 94(1)

This work investigated the effects of 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294) treatment on the contractile response of soleus (SOL) muscle from rats submitted to myocardial infarction (MI).Following coronary artery ligation, LASSBi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46ac46e57b14009d285191cb455d591
https://pubmed.ncbi.nlm.nih.gov/24269214

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