Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sharlene G. Rakoczy"'
Autor:
Rachana Trivedi, Sharlene G. Rakoczy, Mary Lizakowski, Holly M. Brown-Borg, Donald A. Jurivich, Gunjan D. Manocha
Publikováno v:
J Gerontol A Biol Sci Med Sci
Age-dependent perturbation of the cellular stress response affects proteostasis and other key functions relevant to cellular action and survival. Central to age-related changes in the stress response is loss of heat shock factor 1 (HSF1)–DNA bindin
Autor:
Lalida Rojanathammanee, Holly M. Brown-Borg, Kurt E. Borg, Joseph A. Wonderlich, Sharlene G. Rakoczy
Publikováno v:
Annals of the New York Academy of Sciences. 1418:118-136
Extension of mammalian health and life span has been achieved using various dietary interventions. We previously reported that restricting dietary methionine (MET) content extends lifespan only when growth hormone signaling is intact (no lifespan inc
Multiple biological and environmental factors impact the health and life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction and the response to stress, amon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3de840c172d569f98d03f013a7c9ba4
https://europepmc.org/articles/PMC6227254/
https://europepmc.org/articles/PMC6227254/
Autor:
Holly M. Brown-Borg, Colin K. Combs, Kendra L. Puig, Whitney Franklin, Joshua A. Kulas, Giulio Taglialatela, Sharlene G. Rakoczy
Publikováno v:
Neurobiology of Aging. 40:22-40
APP/PS1 double transgenic mice expressing human mutant amyloid precursor protein (APP) and presenilin-1 (PS-1) demonstrate robust brain Aβ peptide containing plaque deposition, increased markers of oxidative stress, behavioral dysfunction, and proin
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 69:923-933
Methyltransferase expression and DNA methylation are linked to aging and age-related disease. We utilized 3-, 12-, and 24-month-old Ames dwarf and their wild-type siblings to examine the genotype and age-related differences in the expression of methy
Publikováno v:
Experimental Gerontology. 48:905-919
Restrictive dietary interventions exert significant beneficial physiological effects in terms of aging and age-related disease in many species. Every other day feeding (EOD) has been utilized in aging research and shown to mimic many of the positive
Publikováno v:
Innovation in Aging. 1:1217-1218
Exceptional longevity in humans and other species appear to be linked to a vigorous cellular stress response that is otherwise suppressed with normal aging or frailty. Most studies thus far have evaluated serum and tissue levels of the heat shock pro
Publikováno v:
AGE. 34:609-620
In the current study, we investigated changes in N-methyl d-aspartate (NMDA) and kainate receptor expression, long-term potentiation (LTP), and neurogenesis in response to neurotoxic stress in long-living Ames dwarf mice. We hypothesized that Ames dw
Publikováno v:
AGE. 34:43-57
Reduced signaling of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is associated with extended life span in several species. Ames dwarf mice are GH-deficient and live50% longer than wild-type littermates. Previously, we have sh
Publikováno v:
Mechanisms of Ageing and Development. 131:422-435
Age associated cognitive impairment is associated with low levels of IGF-1, oxidative stress, and neuronal loss in the hippocampus. Ames dwarf mice are long-lived animals that exhibit peripheral IGF-1 deficiency. Hippocampal-based spatial memory (a h