Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sharlene Day"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 3-3 (2024)
OBJECTIVES/GOALS: Study the regulatory role of sodium glucose co-transporter 1 (SGLT1) in cardiomyocytes and the therapeutic potential of sotagliflozin in hypertrophic cardiomyopathy (HCM) by (a) quantifying SGLT1 expression in HCM and (b) examining
Externí odkaz:
https://doaj.org/article/75a9baed77c84cfa9b32f9a3daa6094c
Autor:
Thomas L. Lynch, IVPhD, Diederik W.D. Kuster, PhD, Beverly Gonzalez, ScM, Neelam Balasubramanian, BA, Nandini Nair MD, PhD, Sharlene Day, PhD, Jenna E. Calvino, BA, Yanli Tan, RN, Christoph Liebetrau, MD, Christian Troidl, PhD, Christian W. Hamm, MD, Ahmet Güçlü, MD, Barbara McDonough, RN, Ali J. Marian, MD, Jolanda van der Velden, PhD, Christine E. Seidman, MD, Gordon S. Huggins, MD, Sakthivel Sadayappan, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 2, Pp 122-131 (2017)
Summary: The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with advers
Externí odkaz:
https://doaj.org/article/29446172fbb5404fb9ce3f58703a24fc
Publikováno v:
European Journal of Preventive Cardiology. 30:488-495
HCM has long been considered the most frequent cause of death in athletes, and reason for disqualification from sport. However, our perception of the impact of sports on HCM is largely based on anecdotal evidence. In this review, we provide a reappra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1fa248882ef07ba62b6731d9666b529
https://doi.org/10.1093/eurjpc/zwad011
https://doi.org/10.1093/eurjpc/zwad011
Publikováno v:
Physiology. 38
Rationale: Hypertrophic Cardiomyopathy (HCM) is an inherited cardiovascular disease that affects 1 in 500 people. Over half of familial HCM cases arise from MyBP-C haploinsufficiency, thus stabilizing MyBP-C protein expression is an appealing therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00860291483510c860c2204fc750a1f6
https://doi.org/10.1152/physiol.2023.38.s1.5735171
https://doi.org/10.1152/physiol.2023.38.s1.5735171
Publikováno v:
Physiology. 38
Background: Hypertrophic cardiomyopathy (HCM) is the most common genetically inherited cardiovascular disease that affects one in 500 people. Variants in MYBPC3 result in premature termination codons, ultimately causing haploinsufficiency in MyBP-C p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4997d2e6d3b7b09feaf476355926ea0
https://doi.org/10.1152/physiol.2023.38.s1.5734001
https://doi.org/10.1152/physiol.2023.38.s1.5734001
Autor:
Jonathan Herrera, Danielle Szczesniak, Kate Szczesniak, Rose‐Carmel Goddard, Jaime Yob, Sharlene Day
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c9d5192c1e1efa957f4d8be1869c96
https://doi.org/10.1096/fasebj.2022.36.s1.l8091
https://doi.org/10.1096/fasebj.2022.36.s1.l8091
Autor:
Eric Smith, Brynn Elder, Gabriela Chen, Yao-chang Tsan, John Stendahl, Jodie Ingles, Victoria N Parikh, Samuel Wittekind, Steven Colan, Neal K Lakdawala, Anjali T Owens, Daniel L Jacoby, Sharlene Day, Christopher Semsarian, iacopo olivotto, Carolyn Ho, Mark W Russell, Sara Saberi, James S Ware, Adam S Helms
Publikováno v:
Circulation. 144
Introduction: Genetic hypertrophic cardiomyopathy (HCM) is an autosomal dominant inherited condition primarily due to pathogenic variants in sarcomere genes, often with marked clinical variability. We hypothesized that this variability may, in part,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5c7cd9ca0ced853f403f63bde6b602
https://doi.org/10.1161/circ.144.suppl_1.11792
https://doi.org/10.1161/circ.144.suppl_1.11792
Autor:
Thomas M Roston, iacopo olivotto, Sharlene Day, Victoria N Parikh, Michelle Michels, Jodie Ingles, Christopher Semsarian, Daniel L Jacoby, Steven D Colan, Joseph Rossano, Samuel Wittekind, James S Ware, Lin Zhang, Sara Saberi, Adam S Helms, Carolyn Ho
Publikováno v:
Circulation. 144
Introduction: Pressure overload from hypertension (HTN) is an important cause of left ventricular hypertrophy (LVH) in the general population, however its impact on disease expression in hypertrophic cardiomyopathy (HCM), and differences based on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3135927465131b2d5e128dd9b0f8f7b6
https://doi.org/10.1161/circ.144.suppl_1.11709
https://doi.org/10.1161/circ.144.suppl_1.11709
Autor:
Rachel Lampert, Michael J Ackerman, Bradley S Marino, Matthew Burg, Barbara Ainsworth, Lisa Salberg, Maite Tome, Seshadri Balaji, Carolyn Ho, Richard J Czosek, Cynthia James, Michael Emery, Robert Cooper, Martijn Bos, Jeffrey B Geske, Lubna Choudhury, Susan P Etheridge, Ashwin K Lal, James S Ware, Anne M Dubin, Belinda Gray, Silvana M Molossi, Martin S Maron, Sara Saberi, Daniel L Jacoby, Benjamin W Eidem, Kimberly Harmon, Kevin Hall, Brian Olshansky, Mark S Link, Ian Law, Elizabeth V Saarel, N A Estes, Barry Maron, David S Cannom, Fangyong Li, Kaylie Briske, Laura Simone, Cheryl Barth, Maryann Concannon, Sharlene Day
Publikováno v:
Circulation. 144
Introduction: Safety of vigorous exercise for individuals with appropriately-treated HCM remains debated. Physical activity practices in this population have not been described. The objective of this report is to describe physical activity pattern in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c253607a971307c92c78ef528cdb87e3
https://doi.org/10.1161/circ.144.suppl_1.9544
https://doi.org/10.1161/circ.144.suppl_1.9544
Autor:
Michael Levin, Noah Tsao, Tiffany Bellomo, William P Bone, Renae Judy, Megan Burke, Michael Morley, Yifan Yang, Sharlene Day, Zoltan Arany, Patrick T Ellinor, Thomas P Cappola, Kenneth B Margulies, Benjamin F Voight, Scott Damrauer
Publikováno v:
Circulation. 144
Introduction: The contribution of common genetic variation to heart failure (HF) risk has not been fully elucidated. Here, we applied multi-ancestry and multivariate methods to summary genetic data from >1 million individuals to improve power to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac1c86ea628db3e03d08e8e134603ff7
https://doi.org/10.1161/circ.144.suppl_1.10770
https://doi.org/10.1161/circ.144.suppl_1.10770