Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sharleen V. Menezes"'
Publikováno v:
International Journal of Cancer. 148:2375-2388
Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene transcription during both development and malignant transformation. Depending
Autor:
Sharleen V. Menezes, Bekesho Geleta, Leyla Fouani, Des R. Richardson, Michael L.-H. Huang, Sanaz Maleki, Alexander Richardson, Zaklina Kovacevic
Publikováno v:
Carcinogenesis. 40:805-818
The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal transition (EMT), a key step in metastasis. In this investigation, NDRG1 inhi
Autor:
Terrance Grant Johns, Tara A. Betts, Brett W. Stringer, Sharleen V. Menezes, Joonas Haapasalo, Kristiina Nordfors, Bryan W. Day, Athena F Phoa, Michael E. Buckland, Hannu Haapasalo, Lenka Munoz, Ariadna Recasens, Diep Chau, Najoua Lalaoui, Fadi M S Gurgis
Publikováno v:
Cancers
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 654 (2020)
Volume 12
Issue 3
Cancers, Vol 12, Iss 3, p 654 (2020)
MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While TP53 deletion is rare in glioblastomas, these tumors often carry TP53 mutations. Here, we
Autor:
Kyung Chan Park, Danuta S. Kalinowski, Sumit Sahni, Des R. Richardson, Zaklina Kovacevic, Patric J. Jansson, Sharleen V. Menezes
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:2644-2663
The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), exhibits pleiotropic activity, inhibiting metastasis of various tumor-types, while being correlated with metastasis in others. Notably, NDRG1 phosphorylation and cleavage are assoc
Publikováno v:
Pharmacological Research. 115:275-287
Metastasis is currently the leading cause of cancer related death and is the most feared and difficult to treat outcome for cancer patients. This complex process is regulated by a plethora of signaling pathways and molecules that control cell prolife
Autor:
Sharleen V. Menezes, Minhua Zheng, Kyung Chan Park, Jiaoyang Lu, Ruxing Xi, Xiongzhi Wangpu, Michael L.H. Huang, Des R. Richardson, Sumit Sahni, Zaklina Kovacevic, Fei Yue
Publikováno v:
Molecular Pharmacology. 89:521-540
Metastasis is a complex process that is regulated by multiple signaling pathways, with the focal adhesion kinase (FAK)/paxillin pathway playing a major role in the formation of focal adhesions and cell motility. N-myc downstream regulated gene-1 (NDR
Autor:
Sharleen V. Menezes, Sumit Sahni, Dong-Hun Bae, Des R. Richardson, Darius J.R. Lane, Danuta S. Kalinowski, Zaklina Kovacevic
Publikováno v:
Journal of Biological Chemistry. 291:1029-1052
N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pathway, protein kinase B (AKT)/PI3K pathway, RAS,
Publikováno v:
The Journal of biological chemistry. 294(11)
The metastasis suppressor, N-Myc downstream-regulated gene-1 (NDRG1) inhibits a plethora of oncogenic signaling pathways by down-regulating the epidermal growth factor receptor (EGFR). Herein, we examined the mechanism involved in NDRG1-mediated EGFR
Autor:
Sumit Sahni, Darius J.R. Lane, Patric J. Jansson, Sharleen V. Menezes, Sukriti Krishan, Zaklina Kovacevic, Danuta S. Kalinowski, Michael L.-H. Huang, Des R. Richardson
Publikováno v:
Future Medicinal Chemistry. 8:727-729
The tumor microenvironment has received considerable attention in terms of designing pharmacological strategies for optimising cancer treatment. Considering this, it is notable that the microenvironment of the cancer
Publikováno v:
The Journal of biological chemistry. 292(31)
The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer cells. Recent findings have demonstrated that NDRG1 inhibits the ErbB family of receptors, wh