Výsledky vyhledávání - "Sharla M O, Phipps"

Retinoid-induced histone deacetylation inhibits telomerase activity in estrogen receptor-negative breast cancer cells

Autor: Sharla M O, Phipps, William K, Love, Teresa, White, Lucy G, Andrews, Trygve O, Tollefsbol

Publikováno v: Anticancer research. 29(12)

Multiple mechanisms regulate cancer-associated telomerase activity at the level of human telomerase reverse transcriptase (hTERT) transcription which may serve as novel targets for anticancer approaches.The effects of prolonged all-trans retinoic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fed79665d3f9b8b5ae5708c559805b9
https://pubmed.ncbi.nlm.nih.gov/20044602

Zobrazit plný text záznamu

Differential Expression of Epigenetic Modulators During Human Embryonic Stem Cell Differentiation

Autor: Trygve O. Tollefsbol, Sharla M. O. Phipps, Troy E. Mott, William K. Love, Lucy G. Andrews

Although the progression of aging and the diseases associated with it are extensively studied, little is known about the initiation of the aging process. Telomerase is down-regulated early in embryonic differentiation, thereby contributing to telomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe879393aaad51a3757fd7d1a4af8049
https://europepmc.org/articles/PMC2629501/

Zobrazit plný text záznamu

The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells

Autor: Joel B. Berletch, Lucy G. Andrews, Wayne J. Brouillette, J. Tyson DeAngelis, William K. Love, Trygve O. Tollefsbol, Donald D. Muccio, Sharla M. O. Phipps

Publikováno v: Translational oncology. 1(3)

Telomerase, a ribonucleoprotein important to neoplastic immortality, is up-regulated in approximately 85% of cancers, including leukemias. In this study, 9cUAB30, a novel retinoic acid, resulted in differentiation of HL60 leukemia cells as indicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba28a1e7848b8d2c6a46b962c6575961
https://pubmed.ncbi.nlm.nih.gov/18795149

Zobrazit plný text záznamu

Aging cell culture: methods and observations

Autor: Sharla M O, Phipps, Joel B, Berletch, Lucy G, Andrews, Trygve O, Tollefsbol

Publikováno v: Methods in molecular biology (Clifton, N.J.). 371

Culturing and subcultivation of normal human diploid fibroblasts have advanced our understanding of the molecular events involved in aging. This progress is leading to the development of therapies that slow or ablate the adverse physiological and pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d5d79852da9605ed7ce7221672b1db8
https://pubmed.ncbi.nlm.nih.gov/17634570

Zobrazit plný text záznamu

A method to study the expression of DNA methyltransferases in aging systems in vitro

Autor: Joel B. Berletch, Lucy G. Andrews, Trygve O. Tollefsbol, Sharla M. O. Phipps, Sabrina L. Walthall

Publikováno v: Methods in Molecular Biology ISBN: 9781588296580

The methylation of CpG dinucleotides located in key protein binding sites within gene regulatory regions often leads to gene silencing. A mechanism of aging is proposed whereby an accumulation of methylation at gene regulatory sites contributes to ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202fdbc57768a75cfada3d321f918322
https://pubmed.ncbi.nlm.nih.gov/17634575

Zobrazit plný text záznamu

The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells

Autor: Nathan J. Hansen, Trygve O. Tollefsbol, William K. Love, Sharla M. O. Phipps, Rebecca C. Wylie, Lucy G. Andrews

Publikováno v: International Journal of Oncology.

Retinoic acids and their derivatives potentiate anti-cancer effects in breast cancer cells. The aberrant expression of telomerase is critical to the continued proliferation of most cancer cells. Thus, telomerase is an attractive target for chemo-prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73666e70d3753df6c8741d69789cdc0b
https://doi.org/10.3892/ijo.30.3.641

Zobrazit plný text záznamu