Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sharla M Birch"'
Autor:
Paul T Martin, Deborah A Zygmunt, Anna Ashbrook, Sonia Hamilton, Davin Packer, Sharla M Birch, Amanda K Bettis, Cynthia J Balog-Alvarez, Lee-Jae Guo, Peter P Nghiem, Joe N Kornegay
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248721 (2021)
We have examined the effects of intravenous (IV) delivery of rAAVrh74.MHCK7.GALGT2 in the golden retriever muscular dystrophy (GRMD) model of Duchenne Muscular Dystrophy (DMD). After baseline testing, GRMD dogs were treated at 3 months of age and rea
Externí odkaz:
https://doaj.org/article/8daea8ae30e441fc877a6ae566d3dfd6
Autor:
Kritika Khanna, Wilfred W. Raymond, Jing Jin, Annabelle R. Charbit, Irina Gitlin, Monica Tang, Adam D. Werts, Edward G. Barrett, Jason M. Cox, Sharla M. Birch, Rachel Martinelli, Hannah S. Sperber, Sergej Franz, Thomas Duff, Markus Hoffmann, Anne Marie Healy, Stefan Oscarson, Stefan Pöhlmann, Satish K. Pillai, Graham Simmons, John V. Fahy
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L372-L389
The redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) is important for the binding of SARS-2-S to angiotensin-converting enzyme 2 (ACE2), suggesting that drugs with a functional thiol group (“thiol drugs”) may cleave cyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed0e1d52f190a90985b7184a51c0b59
https://doi.org/10.1152/ajplung.00136.2022
https://doi.org/10.1152/ajplung.00136.2022
Autor:
Sharla M. Birch, Michael W. Lawlor, Thomas J. Conlon, Lee-Jae Guo, Julie M. Crudele, Eleanor C. Hawkins, Peter P. Nghiem, Mihye Ahn, Hui Meng, Margaret J. Beatka, Brittany A. Fickau, Juan C. Prieto, Martin A. Styner, Michael J. Struharik, Courtney Shanks, Kristy J. Brown, Diane Golebiowski, Amanda K. Bettis, Cynthia J. Balog-Alvarez, Nathalie Clement, Kirsten E. Coleman, Manuela Corti, Xiufang Pan, Stephen D. Hauschka, J. Patrick Gonzalez, Carl A. Morris, Joel S. Schneider, Dongsheng Duan, Jeffrey S. Chamberlain, Barry J. Byrne, Joe. N. Kornegay
Publikováno v:
Science translational medicine. 15(677)
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by the absence of dystrophin, a membrane-stabilizing protein encoded by the DMD gene. Although mouse models of DMD provide insight into the potential of a corrective the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286334212cdab7cd1ec6f09084ab2d3f
https://pubmed.ncbi.nlm.nih.gov/36599002
https://pubmed.ncbi.nlm.nih.gov/36599002
Autor:
Sarah N Tedjakusuma, Clarissa I Martinez, Adam Werts, Adriana E. Kajon, Emery G. Dora, Sean N. Tucker, Susan A. Johnson, Sharla M Birch, Nadine Peinovich
Publikováno v:
The Journal of Infectious Diseases
Background Vaccines that are shelf stable and easy to administer are crucial to improve vaccine access and reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission around the world. Methods In this study, we demonstrate that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3428b25ed53cfe0861cbce870d476aa2
https://doi.org/10.1093/infdis/jiab561
https://doi.org/10.1093/infdis/jiab561
Autor:
Justin Dearing, Abigail Conte, Catherine Brooks, Anna Zimina, Rhiannon Rivas, Sharla M. Birch, Danielle R. Adney, Maggie Li, Adriana Rascon, George A. Belov, Andrew Pekosz, Meghan S. Vermillion
Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in children. Currently, there are no approved vaccines or treatments for EV-D68 infection, and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f069e97b362a9cc15f90d1d60c6f78ed
https://doi.org/10.1101/2022.04.16.487524
https://doi.org/10.1101/2022.04.16.487524
Autor:
Sharla M. Birch, Lejla Alic, Joe N. Kornegay, John F. Griffin, Wade Friedeck, Jim Ji, Aydin Eresen
Publikováno v:
Muscle & Nerve. 59:380-386
INTRODUCTION Golden retriever muscular dystrophy (GRMD), an X-linked recessive disorder, causes similar phenotypic features to Duchenne muscular dystrophy (DMD). There is currently a need for a quantitative and reproducible monitoring of disease prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7259292e8e21ac7a59c60a5a392aac2
https://doi.org/10.1002/mus.26386
https://doi.org/10.1002/mus.26386
Autor:
Kritika, Khanna, Wilfred, Raymond, Jing, Jin, Annabelle R, Charbit, Irina, Gitlin, Monica, Tang, Adam D, Werts, Edward G, Barrett, Jason M, Cox, Sharla M, Birch, Rachel, Martinelli, Hannah S, Sperber, Sergej, Franz, Satish, Pillai, Anne Marie, Healy, Thomas, Duff, Stefan, Oscarson, Markus, Hoffmann, Stefan, Pöhlmann, Graham, Simmons, John V, Fahy
Publikováno v:
bioRxiv : the preprint server for biology.
Neutrophil-induced oxidative stress is a mechanism of lung injury in COVID-19, and drugs with a functional thiol group ("thiol drugs"), especially cysteamine, have anti-oxidant and anti-inflammatory properties that could limit this injury. Thiol drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47e29fd26b887cac3e4fdc4888119611
https://pubmed.ncbi.nlm.nih.gov/33330868
https://pubmed.ncbi.nlm.nih.gov/33330868
Publikováno v:
Journal of the American Veterinary Medical Association. 253:423-426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2d3aa1e7865bf70632f78010f4b987
https://doi.org/10.2460/javma.253.4.423
https://doi.org/10.2460/javma.253.4.423
Publikováno v:
IEEE transactions on bio-medical engineering. 66(5)
Objective: Histology is often used as a gold standard to evaluate noninvasive imaging modalities such as a magnetic resonance imaging (MRI). Spatial correspondence between histology and MRI is a critical step in quantitative evaluation of skeletal mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b3b855a4dcd2679668e1e09695118c
https://pubmed.ncbi.nlm.nih.gov/30235115
https://pubmed.ncbi.nlm.nih.gov/30235115
Autor:
Sharla M. Birch, John F. Griffin, Joe N. Kornegay, Aydin Eresen, Jim Ji, Noor E. Hafsa, Lejla Alic
Publikováno v:
Muscle and Nerve, 60(5), 621-628. Wiley
Introduction Golden retriever muscular dystrophy (GRMD) is a spontaneous X-linked canine model of Duchenne muscular dystrophy that resembles the human condition. Muscle percentage index (MPI) is proposed as an imaging biomarker of disease severity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f060fd8b11872162d74869c6281cabc5
https://pubmed.ncbi.nlm.nih.gov/31397906
https://pubmed.ncbi.nlm.nih.gov/31397906