Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.

Autor: Cleynen I; Department of Human Genetics, KU Leuven, Leuven, Belgium., Engchuan W; The Centre for Applied Genomics (TCAG), The Hospital for Sick Children, Toronto, ON, Canada., Hestand MS; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Heung T; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Dalglish Family 22q Clinic, Toronto General Hospital, University Health Network, Toronto, ON, Canada., Holleman AM; Department of Epidemiology, Emory University, Atlanta, GA, USA., Johnston HR; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Monfeuga T; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., McDonald-McGinn DM; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Gur RE; Department of Psychiatry and Lifespan Brain Institute, Penn Medicine-CHOP, University of Pennsylvania, Philadelphia, PA, USA., Morrow BE; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Swillen A; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Vorstman JAS; Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Bearden CE; Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Chow EWC; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., van den Bree M; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Emanuel BS; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Vermeesch JR; Department of Human Genetics, KU Leuven, Leuven, Belgium., Warren ST; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Chopra P; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Cutler DJ; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Duncan R; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Kotlar AV; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Mulle JG; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Voss AJ; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Zwick ME; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Diacou A; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Golden A; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Guo T; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Lin JR; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Wang T; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Zhang Z; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Zhao Y; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Marshall C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genome Diagnostics, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Merico D; The Centre for Applied Genomics (TCAG), The Hospital for Sick Children, Toronto, ON, Canada.; Deep Genomics Inc., Toronto, ON, Canada., Jin A; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lilley B; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Salmons HI; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Tran O; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Holmans P; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Pardinas A; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Walters JTR; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Demaerel W; Department of Human Genetics, KU Leuven, Leuven, Belgium., Boot E; Dalglish Family 22q Clinic, Toronto General Hospital, University Health Network, Toronto, ON, Canada., Butcher NJ; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada., Costain GA; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Hospital for Sick Children, Toronto, ON, Canada., Lowther C; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada., Evers R; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., van Amelsvoort TAMJ; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., van Duin E; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Vingerhoets C; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands., Breckpot J; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Devriendt K; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Vergaelen E; Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Vogels A; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Crowley TB; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., McGinn DE; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Moss EM; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Sharkus RJ; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Unolt M; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Zackai EH; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics and 22q and You Center, the Children's Hospital of Philadelphia, Philadelphia, PA, USA., Calkins ME; Department of Psychiatry and Lifespan Brain Institute, Penn Medicine-CHOP, University of Pennsylvania, Philadelphia, PA, USA., Gallagher RS; Department of Psychiatry and Lifespan Brain Institute, Penn Medicine-CHOP, University of Pennsylvania, Philadelphia, PA, USA., Gur RC; Department of Psychiatry and Lifespan Brain Institute, Penn Medicine-CHOP, University of Pennsylvania, Philadelphia, PA, USA., Tang SX; Department of Psychiatry and Lifespan Brain Institute, Penn Medicine-CHOP, University of Pennsylvania, Philadelphia, PA, USA., Fritsch R; Universidad de Chile, Santiago, Chile., Ornstein C; Universidad de Chile, Santiago, Chile., Repetto GM; Clinica Alemana Universidad del Desarrollo, Santiago, Chile., Breetvelt E; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada., Duijff SN; Department of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands., Fiksinski A; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands., Moss H; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Niarchou M; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK., Murphy KC; Royal College of Surgeons in Ireland, Dublin, Ireland., Prasad SE; Royal College of Surgeons in Ireland, Dublin, Ireland., Daly EM; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK., Gudbrandsen M; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK., Murphy CM; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK., Murphy DG; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, UK., Buzzanca A; Department of Human Neurosciences, University Sapienza of Rome, Rome, Italy., Fabio FD; Department of Human Neurosciences, University Sapienza of Rome, Rome, Italy., Digilio MC; Ospedale Bambino Gesu Pediatric Hospital, Rome, Italy., Pontillo M; Child and Adolescence Neuropsychiatry Unit, Department of Neuroscience, IRCSS Bambino Gesù Children's Hospital of Rome, Rome, Italy., Marino B; Sapienza University, Rome, Italy., Vicari S; Child and Adolescence Neuropsychiatry Unit, Department of Neuroscience, IRCSS Bambino Gesù Children's Hospital of Rome, Rome, Italy., Coleman K; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Cubells JF; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Ousley OY; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Carmel M; Felsenstein Medical Research Center, Petach Tikva, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Gothelf D; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Child Psychiatry Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel., Mekori-Domachevsky E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Child Psychiatry Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel., Michaelovsky E; Felsenstein Medical Research Center, Petach Tikva, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Weinberger R; The Child Psychiatry Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel., Weizman A; Felsenstein Medical Research Center, Petach Tikva, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Geha Mental Health Center, Petach Tikva, Israel., Kushan L; Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Jalbrzikowski M; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Armando M; Developmental Imaging and Psychopathology, Department of Psychiatry, University of Geneva, Geneva, Switzerland., Eliez S; Developmental Imaging and Psychopathology, Department of Psychiatry, University of Geneva, Geneva, Switzerland., Sandini C; Developmental Imaging and Psychopathology, Department of Psychiatry, University of Geneva, Geneva, Switzerland., Schneider M; Developmental Imaging and Psychopathology, Department of Psychiatry, University of Geneva, Geneva, Switzerland., Béna FS; Department of Medical Genetics, Geneva University Hospitals, Geneva, Switzerland., Antshel KM; Department of Psychology, Syracuse University, Syracuse, NY, USA., Fremont W; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Kates WR; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Belzeaux R; Pôle de psychiatrie, Hopital Sainte Marguerite, Batiment Solaris, APHM, Marseille, France., Busa T; Departement de Genetique Medicale Hôpital d'Enfants de la Timone, APHM, Marseille, France., Philip N; Departement de Genetique Medicale Aix Marseille Univ, INSERM, GMGF, APHM, Marseille, France., Campbell LE; University of Newcastle, Callaghan, Australia., McCabe KL; University of Newcastle, Callaghan, Australia.; University of California Davis, Davis, CA, USA., Hooper SR; Department of Allied Health Sciences, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA., Schoch K; Department of Pediatrics, Division of Medical Genetics, Duke University School of Medicine, Durham, NC, USA., Shashi V; Department of Pediatrics, Division of Medical Genetics, Duke University School of Medicine, Durham, NC, USA., Simon TJ; MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis, Davis, CA, USA., Tassone F; Department of Microbiology and Molecular Medicine, University of California Davis, Davis, CA, USA., Arango C; Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain., Fraguas D; Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain., García-Miñaúr S; Institute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain., Morey-Canyelles J; Hospital Universitari Son Espases, Palma, Spain., Rosell J; Hospital Universitari Son Espases, Palma, Spain., Suñer DH; Laboratorio Unidad de Diagnóstico Molecular y Genética Clínica, Hospital Universitari Son Espases, Palma de Mallorca, Spain., Raventos-Simic J; Hospital Universitari Son Espases, Palma, Spain., Epstein MP; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA. mpepste@emory.edu., Williams NM; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK. williamsnm@cardiff.ac.uk., Bassett AS; Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada. anne.bassett@utoronto.ca.; Dalglish Family 22q Clinic, Toronto General Hospital, University Health Network, Toronto, ON, Canada. anne.bassett@utoronto.ca.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. anne.bassett@utoronto.ca.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2021 Aug; Vol. 26 (8), pp. 4496-4510. Date of Electronic Publication: 2020 Feb 03.