Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sharif A Sabe"'
Autor:
Dwight D Harris, Sharif A Sabe, Mark Broadwin, Chris Stone, Krishna Bellam, Akshay Malhotra, M Ruhul Abid, Frank W Sellke
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307922 (2024)
Although both clinical data and animal models suggest cardiovascular benefits following administration of Dipeptidyl Peptidase 4 (DPP-4) inhibitors, the underlying mechanisms remain unclear. We therefore sought to evaluate the effect of the DPP-4 inh
Externí odkaz:
https://doaj.org/article/96ce12eebdda43b0b8f06562ba6566f8
Autor:
Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight Douglas Harris, Akshay Malhotra, Ahmed Aboulgheit, Madigan Stanley, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 1 (2023)
Background Sodium‐glucose cotransporter‐2 inhibitors are cardioprotective independent of glucose control, as demonstrated in animal models of acute myocardial ischemia and clinical trials. The functional and molecular mechanisms of these benefits
Externí odkaz:
https://doaj.org/article/57ce511c7c794b28b88ed7df1410e55d
Autor:
Sharif A. Sabe, Martin A. Kononov, Krishna G. Bellam, Neel Sodha, Afshin Ehsan, William F. Jackson, Jun Feng, Frank W. Sellke
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 165:e256-e267
Cardioplegia and cardiopulmonary bypass dysregulate coronary vasomotor tone, which can be further affected by common comorbidities in patients undergoing cardiac surgery. This study investigates differences in coronary myogenic tone and vasomotor res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c69ef4fd266bcc691361ab22332e95
https://doi.org/10.1016/j.jtcvs.2022.07.022
https://doi.org/10.1016/j.jtcvs.2022.07.022
Autor:
Sharif A. Sabe, Laura A. Scrimgeour, Catherine Karbasiafshar, Mohamed Sabra, Cynthia M. Xu, Ahmed Aboulgheit, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 165:e225-e236
Extracellular vesicle (EV) therapy has been shown to mitigate inflammation in animal models of acute myocardial ischemia/reperfusion. This study evaluates the effect of EV therapy on inflammatory signaling in a porcine model of chronic myocardial isc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac43b5c922563f13ee06b680c6eb5694
https://doi.org/10.1016/j.jtcvs.2022.07.016
https://doi.org/10.1016/j.jtcvs.2022.07.016
Autor:
Kiera D. Dwyer, Rajeev J. Kant, Arvin H. Soepriatna, Stephanie M. Roser, Mark C. Daley, Sharif A. Sabe, Cynthia M. Xu, Bum-Rak Choi, Frank W. Sellke, Kareen L. K. Coulombe
Publikováno v:
Bioengineering; Volume 10; Issue 5; Pages: 587
Despite the overwhelming use of cellularized therapeutics in cardiac regenerative engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical scale remain limited. This study aims to evaluate the impact of critical biomanu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74984109ea9a73376eef1d4ebc910c6
Autor:
Cynthia M. Xu, Sharif A. Sabe, Rayane Brinck‐Teixeira, Mohamed Sabra, Frank W. Sellke, M. Ruhul Abid
Publikováno v:
Physiological Reports. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2c1aa887ecbea7ce15baf6f5098c3c
https://doi.org/10.14814/phy2.15568
https://doi.org/10.14814/phy2.15568
Publikováno v:
Frontiers in Medicine. 10
Despite significant advances in surgical technique and strategies for tissue/organ protection, cardiac surgery involving cardiopulmonary bypass is a profound stressor on the human body and is associated with numerous intraoperative and postoperative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b93bba3fa8eebd943852fb3135233dd
https://doi.org/10.3389/fmed.2023.1110532
https://doi.org/10.3389/fmed.2023.1110532
Autor:
Sharif A. Sabe, Cynthia M. Xu, Brittany A. Potz, Akshay Malhotra, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2076
Volume 24
Issue 3
Pages: 2076
We have previously shown that normoxia serum-starved extracellular vesicle (EV) therapy improves myocardial function, perfusion, and angiogenesis in a swine model of chronic myocardial ischemia. Hypoxia-modified EVs have increased abundance of anti-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9126cc48e36e535696255ad1bc70bf42
Autor:
Cynthia Marie Xu, Sharif A. Sabe, Rayane Brinck-Teixeira, Mohamed Sabra, Frank W. Sellke, M. Ruhul Abid
Background: In animal models, human bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EV) have beneficial effects in cardiovascular disease (CVD) only when administered via intramyocardial injection. The biodistribution of either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7499a84a600bcb804f280db45bd15c75
https://doi.org/10.21203/rs.3.rs-1910735/v1
https://doi.org/10.21203/rs.3.rs-1910735/v1
Autor:
Sharif A. Sabe, Laura A. Scrimgeour, Cynthia M. Xu, Mohamed Sabra, Catherine Karbasiafshar, Ahmed Aboulgheit, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
The Journal of thoracic and cardiovascular surgery.
Our recent studies using a porcine model of metabolic syndrome (MS) and chronic myocardial ischemia show that extracellular vesicle (EV) therapy improves blood flow and arteriogenesis in ischemic myocardium, although mechanisms of these changes are u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8324d4c41d59a65d57da5b1b871c629
https://pubmed.ncbi.nlm.nih.gov/36244819
https://pubmed.ncbi.nlm.nih.gov/36244819