Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sharie J. Haugabook"'
Autor:
Erica L. Lyons, Daniel Watson, Mohammad S. Alodadi, Sharie J. Haugabook, Gregory J. Tawa, Fady Hannah-Shmouni, Forbes D. Porter, Jack R. Collins, Elizabeth A. Ottinger, Uma S. Mudunuri
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Approximately 4–8% of the world suffers from a rare disease. Rare diseases are often difficult to diagnose, and many do not have approved therapies. Genetic sequencing has the potential to shorten the current diagnostic process,
Externí odkaz:
https://doaj.org/article/e690a548a1d4449da411eb08d584528a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:1003-1018
A challenge in developing effective treatments is the modeling of the human disease using in vitro and in vivo systems. Animal models have played a critical role in the understanding of disease pathophysiology, target validation, and evaluation of no
Autor:
Hongyan Xu, Amy Wang, Asaf Alimardanov, Jose Sangerman, Xin Xu, London Toney, Gregory J. Tawa, Levi Makala, Susan P. Perrine, Roman F. Wolf, Aidan D. Faller, Betty S. Pace, Mayuko Takezaki, Wei Zheng, Junfeng Huang, Biaoru Li, Sharie J. Haugabook
Publikováno v:
Blood Cells Mol Dis
Increased expression of developmentally silenced fetal globin (HBG) reduces the clinical severity of β-hemoglobinopathies. Benserazide has a relatively benign safety profile having been approved for 50 years in Europe and Canada for Parkinson's dise
Autor:
Sharie J. Haugabook, Kevin M. Pawlik, Tobias M. Franks, Meghan S. Vermillion, Christopher S. Rogers, Tim M. Townes, Elizabeth A. Ottinger
Mouse models of sickle cell disease (SCD) that faithfully switch from fetal to adult hemoglobin (Hb) have been important research tools that accelerated advancement towards treatments and cures for SCD. Red blood cells (RBCs) in these animals sickled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3caf0ec7b48b0bfb60ecf896f21bb003
https://doi.org/10.1101/2020.09.15.291864
https://doi.org/10.1101/2020.09.15.291864
Autor:
Betty S. Pace, Hanny Al-Samkari, Sujit Sheth, Abdullah Kutlar, Xin Xu, Pramod S. Terse, Seyed Mehdi Nouraie, Susan P. Perrine, Aidan D Faller, Kevin H.M. Kuo, Sharie J. Haugabook, Sylvia Titi Singer, Arthur J. Sytkowski, Franciscus A. Kuypers, Haksong Jin, Gershwin Blyden, Lanetta Bronté-Hall, Asaf Alimardanov
Publikováno v:
Blood. 138:4159-4159
Increased expression of fetal globin (HBG) has been shown to reduce clinical severity of beta-globin disorders and increase survival in sickle cell disease (SCD), through improved globin chain balance in beta thalassemia and reduced HbS polymerizatio
Autor:
Sharie J. Haugabook, Xin Xu, Susan Perrine-Faller, Kylie M. Konrath, Amy Wang, Emma Hughes, Marc D. Singleton
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S38
Autor:
Georgia B. McGaughey, Samuel L. Graham, M. Katharine Holloway, Sharie J. Haugabook, Paul Zuck, Abigail Wolfe, Katherine Tugasheva, Sanjeev Munshi, Joseph P. Vacca, Timothy Allison, Thomas G. Steele, Alessia Petrocchi, Dennis Colussi, Shawn J. Stachel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:240-244
We have developed a novel series of pyrrolidine derived BACE-1 inhibitors. The potency of the weak initial lead structure was enhanced using library-based SAR methods. The series was then further advanced by rational design while maintaining a minima
Autor:
Amy S. Espeseth, Ivory D. Hills, Shawn J. Stachel, Thomas G. Steele, Georgia B. McGaughey, Sharie J. Haugabook, Samuel L. Graham, Paul Zuck, Timothy Allison, Pablo De Leon, Ashley Nomland, Katherine Tugusheva, Dennis Colussi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:17-20
A small molecule inhibitor of beta-secretase with a unique binding mode has been developed. Crystallographic determination of the enzyme-inhibitor complex shows the catalytic aspartate residues in the active site are not engaged in inhibitor binding.
Publikováno v:
Journal of Neurobiology. 57:183-192
Migration and accumulation of microglial cells at sites of injury are important for nerve repair. Recent studies on the leech central nervous system (CNS), in which synapse regeneration is successful, have shown that nitric oxide (NO) generated immed
Autor:
Juliya Kalinina, Guoxin Wu, Rachel Korn, Bonnie J. Howell, John J. Renger, Jill W. Maxwell, Mary J. Savage, Tanesha Cash-Mason, Sharie J. Haugabook, Alexander McCampbell, Abigail Wolfe, Nathan G. Hatcher, Katherine Tugusheva, Paul J. Shughrue
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(8)
A hallmark of Alzheimer's disease (AD) brain is the amyloid β (Aβ) plaque, which is comprised of Aβ peptides. Multiple lines of evidence suggest that Aβ oligomers are more toxic than other peptide forms. We sought to develop a robust assay to qua