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Akademický článek

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp.

Autor: Gilles Brackman, Shari Celen, Ulrik Hillaert, Serge Van Calenbergh, Paul Cos, Louis Maes, Hans J Nelis, Tom Coenye

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16084 (2011)

BACKGROUND: Many bacteria, including Vibrio spp., regulate virulence gene expression in a cell-density dependent way through a communication process termed quorum sensing (QS). Hence, interfering with QS could be a valuable novel antipathogenic strat

Externí odkaz: https://doaj.org/article/876854067c3f4fcb8054951f1dffc0c0

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AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ

Autor: Tom Coenye, Kartik Baruah, Peter Bossier, Serge Van Calenbergh, Shari Celen, Hans Nelis, Gilles Brackman

Publikováno v: MICROBIOLOGY-SGM

The increase of disease outbreaks caused by Vibrio species in aquatic organisms as well as in humans, together with the emergence of antibiotic resistance in Vibrio species, has led to a growing interest in alternative disease control measures. Quoru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a58438bbc49286ec1eb30bb7bd8679
https://doi.org/10.1099/mic.0.032474-0

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Structure-Activity Relationship of Cinnamaldehyde Analogs as Inhibitors of AI-2 Based Quorum Sensing and Their Effect on Virulence of Vibrio spp

Autor: Tom Coenye, Gilles Brackman, Louis Maes, Shari Celen, Hans Nelis, Serge Van Calenbergh, Paul Cos, Ulrik Hillaert

Publikováno v: PLoS ONE
PLOS ONE
PLoS ONE, Vol 6, Iss 1, p e16084 (2011)

Background: Many bacteria, including Vibrio spp., regulate virulence gene expression in a cell-density dependent way through a communication process termed quorum sensing (QS). Hence, interfering with QS could be a valuable novel antipathogenic strat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9a9a9e75646fe8a82f902f9fa07323
http://europepmc.org/articles/PMC3020944

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Transport and delivery of antimicrobial agents in Burkholderia biofilms

Autor: Tom Coenye, Jo Demeester, Katrien Forier, Kevin Braeckmans, Stefaan C. De Smedt, Anne-Sophie Messiaen, Serge Van Calenbergh, Shari Celen, Hans Nelis

Publikováno v: Journal of Controlled Release. 148:e35-e36

Biofilm infections pose a serious threat for patients who are suffering from cystic fibrosis. Faster decline in lung function and increased mortality is observed when these patients acquire biofilm infections with the gram negative pathogen Burkholde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1199d9658e8b1f47d25be7089c145013
https://doi.org/10.1016/j.jconrel.2010.07.044

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