Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sharesta Khoenkhoen"'
Autor:
Sharesta Khoenkhoen, Monika Ádori, Darío Solís-Sayago, Juliette Soulier, Jamie Russell, Bruce Beutler, Gabriel K. Pedersen, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mice lacking the atypical inhibitory kappa B (IκB) protein, IκBNS, a regulator of the NF-κB pathway encoded by the nfkbid gene, display impaired antibody responses to both T cell-independent (TI) and T cell-dependent (TD) antigens. To better under
Externí odkaz:
https://doaj.org/article/36af7d3f9d0c45939da9ec1ad035fe3f
Autor:
Monika Adori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquin Castro Dopico, Gunilla B. Karlsson Hedestam
Publikováno v:
Cells, Vol 12, Iss 9, p 1229 (2023)
Lipopolysaccharide (LPS) stimulates dual receptor signaling by bridging the B cell receptor and Toll-like receptor 4 (BCR/TLR4). B cells from IκBNS-deficient bumble mice treated with LPS display reduced proliferative capacity and impaired plasma cel
Externí odkaz:
https://doaj.org/article/546a27a20fa44cefbf283fd5d066202e
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Humoral immunity is established after differentiation of antigen-specific B cells into plasma cells (PCs) that produce antibodies of relevant specificities. Defects in the development, activation, or differentiation of B cells severely compromises th
Externí odkaz:
https://doaj.org/article/6e87182d99244ec39908be594e25d846
Autor:
Gabriel K. Pedersen, Xiaohong Li, Sharesta Khoenkhoen, Monika Ádori, Bruce Beutler, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
B-1a cells are mainly generated from fetal liver progenitor cells, peri- and neonatally. The developmental steps and anatomical sites required for these cells to become mature B-1a cells remain elusive. We recently described a phenotypically distinct
Externí odkaz:
https://doaj.org/article/8b3ae91d4c784741b64903958756f9ed
Autor:
Jean L. Scholz, Monika Adori, Gabriel K. Pedersen, Michael P. Cancro, Sharesta Khoenkhoen, Elina Erikson, Gunilla B. Karlsson Hedestam, Julian M. Stark
Publikováno v:
Immunology and Cell Biology
Impaired classical NF‐κB pathway signaling causes reduced antibody responses to T‐independent (TI) antigens. We investigated the potential reasons for defective TI responses in mice lacking the atypical inhibitory kappa B (IκB) protein of the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445d24db6b6fca43a588a67c31168ba4
https://doi.org/10.1111/imcb.12228
https://doi.org/10.1111/imcb.12228
Autor:
Elina Erikson, Monika Ádori, Sharesta Khoenkhoen, Jingdian Zhang, Joanna Rorbach, Xaquin Castro Dopico, Gunilla Karlsson Hedestam
Publikováno v:
Cell Immunol
Mutations causing loss of the NF-kappaB regulator IkappaBNS, result in impaired development of innate-like B cells and defective plasma cell (PC) differentiation. Since productive PC differentiation requires B cell metabolic reprogramming, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabd1939c0408a2d6b03ca68064af6ed
https://doi.org/10.1016/j.cellimm.2022.104516
https://doi.org/10.1016/j.cellimm.2022.104516
Autor:
Joanna Rorbach, Mattias Forsell, Gunilla B. Karlsson Hedestam, Chris Wallace, Soo Aleman, Leo Hanke, Monika Adori, Jonathan M. Coquet, Joakim Dillner, Laura Perez Vidakovics, Ainhoa Moliner Morro, Gordana Bogdanovic, Sharesta Khoenkhoen, Marco Mandolesi, Jan Albert, Ben Murrell, Nastasiya F. Grinberg, Marcus Ahl, Daniel J. Sheward, Tobias Allander, Murray Christian, Pradeepa Pushparaj, Sandra Muschiol, Gerald M. McInerney, Xaquin Castro Dopico, Martin Corcoran, Changil Kim
Antibody responses vary widely between individuals1, complicating the correct classification of low-titer measurements using conventional assay cut-offs. We found all participants in a clinically diverse cohort of SARS-CoV-2 PCR+ individuals (n=105)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba8eb79e6f927830d135a4dc40cb115
https://doi.org/10.1101/2020.07.17.20155937
https://doi.org/10.1101/2020.07.17.20155937
Autor:
Bruce Beutler, Csaba Adori, Mikael C. I. Karlsson, Gunilla B. Karlsson Hedestam, Elina Erikson, Monika Adori, Julian M. Stark, Gabriel K. Pedersen, Pia Dosenovic, Jin Huk Choi, Sharesta Khoenkhoen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(2)
Marginal zone (MZ) B cells reside in the splenic MZ and play important roles in T cell–independent humoral immune responses against blood-borne pathogens. IκBNS-deficient bumble mice exhibit a severe reduction in the MZ B compartment but regain an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e564714d2e2d7a77bee5d8fd05913625
https://pubmed.ncbi.nlm.nih.gov/29222168
https://pubmed.ncbi.nlm.nih.gov/29222168
Autor:
Carrie N. Arnold, Bruce Beutler, Julian M. Stark, Gabriel K. Pedersen, Sharesta Khoenkhoen, Gunilla B. Karlsson Hedestam, Monika Adori
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology
Frontiers in Immunology
Mice deficient in central components of classical NF-κB signaling have low levels of circulating natural IgM antibodies and fail to respond to immunization with T-independent type 2 (TI-2) antigens. A plausible explanation for these defects is the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce7679d74f16758919def52052d5eda
https://doi.org/10.3389/fimmu.2016.00065
https://doi.org/10.3389/fimmu.2016.00065
Autor:
Bruce Beutler, Gunilla B. Karlsson Hedestam, Gabriel K. Pedersen, Sharesta Khoenkhoen, Pia Dosenovic, Monika Adori
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(39)
B-1 cells mediate early protection against infection by responding to T cell-independent (TI) antigens found on the surface of various pathogens. Mice with impaired expression of the atypical IκB protein IκBNS have markedly reduced frequencies of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33442275f43359414201bdbda1537adf
https://pubmed.ncbi.nlm.nih.gov/25228759
https://pubmed.ncbi.nlm.nih.gov/25228759