14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Autor: Simone M. Schoenwaelder, Roxane Darbousset, Susan L. Cranmer, Hayley S. Ramshaw, Stephanie L. Orive, Sharelle Sturgeon, Yuping Yuan, Yu Yao, James R. Krycer, Joanna Woodcock, Jessica Maclean, Stuart Pitson, Zhaohua Zheng, Darren C. Henstridge, Dianne van der Wal, Elizabeth E. Gardiner, Michael C. Berndt, Robert K. Andrews, David E. James, Angel F. Lopez, Shaun P. Jackson

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)

Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and

Externí odkaz: https://doaj.org/article/b523399dd63e458a9df758471882f328

N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection

Autor: S. Sadia Ameen, Nane Griem-Krey, Antoine Dufour, M. Iqbal Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik F. Draxler, Robert L. Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep Dhillon, Jet Phey Lim, Faiza Basheer, Hong-Jian Zhu, Laita Bokhari, Carli L. Roulston, Prasad N. Paradkar, Oded Kleifeld, Andrew N. Clarkson, Petrine Wellendorph, Giuseppe D. Ciccotosto, Nicholas A. Williamson, Ching-Seng Ang, Heung-Chin Cheng

Publikováno v: Ameen, S S, Griem-Krey, N, Dufour, A, Hossain, M I, Hoque, A, Sturgeon, S, Nandurkar, H, Draxler, D F, Medcalf, R L, Kamaruddin, M A, Lucet, I S, Leeming, M G, Liu, D, Dhillon, A, Lim, J P, Basheer, F, Zhu, H J, Bokhari, L, Roulston, C L, Paradkar, P N, Kleifeld, O, Clarkson, A N, Wellendorph, P, Ciccotosto, G D, Williamson, N A, Ang, C S & Cheng, H C 2023, ' N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection ', Molecular & cellular proteomics : MCP, vol. 22, no. 5, 100543 . https://doi.org/10.1016/j.mcpro.2023.100543
Molecular & cellular proteomics : MCP, vol 22, iss 5

Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity, the ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a980e6e528169653b1b0ed50175569
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf

Author Reply to Peer Reviews of An Atlas of Phosphorylation and Proteolytic Processing Events During Excitotoxic Neuronal Death Reveals New Therapeutic Opportunities

Autor: Heung-Chin Cheng, Ching-Seng Ang, Nicholas A. Williamson, D. Ciccotosto Giuseppe, Oded Kleifeld, Carli Roulston, Laita Bokhari, Hong-Jian Zhu, Jet Phey Lim, Amardeep Dhillon, Dazhi Liu, Michael G. Leeming, Isabelle S. Lucet, Mohd Aizuddin Kamaruddin, Robert Medcalf, Dominik Draxler, Harshal Nandurkar, Sharelle Sturgeon, Ashfaqul Hoque, M. Iqbal Hossain, Antoine Dufour, S. Sadia Ameen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ece1fed5db32a62d89d4dd92fe3af665
https://doi.org/10.15252/rc.2022884848