Directed evolution of hyperactive integrases for site specific insertion of transgenes.

Autor: Hew BE; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Gupta S; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Sato R; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Waller DF; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Stoytchev I; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Short JE; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Sharek L; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Tran CT; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA., Badran AH; Department of Chemistry, Department of Integrative Structural and Computational Biology, Beckman Center for Chemical Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA., Owens JB; Department of Cell and Molecular Biology, Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96814, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Aug 12; Vol. 52 (14), pp. e64.

Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment.

Autor: Vitorakis, Nikolaos¹ (AUTHOR) nikolas.vitorakis@gmail.com, Gargalionis, Antonios N.² (AUTHOR) agargal@med.uoa.gr, Papavassiliou, Kostas A.³ (AUTHOR) konpapav@med.uoa.gr, Adamopoulos, Christos^1,4 (AUTHOR) cadamop@med.uoa.gr, Papavassiliou, Athanasios G.¹ (AUTHOR) cadamop@med.uoa.gr

Publikováno v: Cancers. Aug2024, Vol. 16 Issue 16, p2876. 26p.

The Nuclear RhoA Exchange Factor Net1 Interacts with Proteins of the Dlg Family, Affects Their Localization, and Influences Their Tumor Suppressor Activity

Autor: Garcia-Mata, R., Frost, J. A., Dubash, A. D., Sharek, L., Burridge, K., Carr, H. S.

Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote transformation. Net1 contains a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85c63270da9f25c4d314e629910b3053

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction.

Autor: Graham DM; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.; UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Andersen T; Laboratoire Interdisciplinaire de Physique, Université Grenoble Alpes, Grenoble, France., Sharek L; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC., Uzer G; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Mechanical and Biomedical Engineering, Boise State University, Boise, ID., Rothenberg K; Department of Biomedical Engineering, Duke University, Durham, NC., Hoffman BD; Department of Biomedical Engineering, Duke University, Durham, NC., Rubin J; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC., Balland M; Laboratoire Interdisciplinaire de Physique, Université Grenoble Alpes, Grenoble, France., Bear JE; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC jbear@email.unc.edu.; UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Burridge K; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC keith_burridge@med.unc.edu.; UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Publikováno v: The Journal of cell biology [J Cell Biol] 2018 Mar 05; Vol. 217 (3), pp. 895-914. Date of Electronic Publication: 2018 Jan 19.

Proteins Involved in Focal Cell Adhesion and Podosome Formation Are Differentially Expressed during Colorectal Tumorigenesis in AOM-Treated Rats.

Autor: Swain, Ian X.¹ (AUTHOR) adam.kresak@uhhospitals.org, Kresak, Adam M.¹ (AUTHOR)

Publikováno v: Cancers. May2024, Vol. 16 Issue 9, p1678. 16p.