Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

Autor: Donal J Cox, Sarah A Connolly, Cilian Ó Maoldomhnaigh, Aenea AI Brugman, Olivia Sandby Thomas, Emily Duffin, Karl M Gogan, Oisin Ó Gallchobhair, Dearbhla M Murphy, Sinead A O'Rourke, Finbarr O'Connell, Parthiban Nadarajan, James J Phelan, Laura E Gleeson, Sharee A Basdeo, Joseph Keane

Publikováno v: eLife, Vol 13 (2024)

Airway macrophages (AM) are the predominant immune cell in the lung and play a crucial role in preventing infection, making them a target for host directed therapy. Macrophage effector functions are associated with cellular metabolism. A knowledge ga

Externí odkaz: https://doaj.org/article/9c3246ecbdeb45c6a9668ba8b1cd623a

Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis

Autor: Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact

Externí odkaz: https://doaj.org/article/a9b01451cc7f44639429c99ff0a2bc3b

The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages

Autor: Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Fergal D. Malone, Joseph Keane, Sharee A. Basdeo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The Warburg effect, defined as increased glycolysis and decreased oxidative phosphorylation, occurs in murine macrophages following LPS stimulation and is required for activation. There are differences between human and murine macrophage metabolic re

Externí odkaz: https://doaj.org/article/dd41be26f8eb47d9beaaaaf1885151c4

Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis

Autor: James Joseph Phelan, Kate McQuaid, Colin Kenny, Karl Michael Gogan, Dónal J. Cox, Sharee Ann Basdeo, Seónadh O’Leary, Simone Christa Tazoll, Cilian Ó Maoldomhnaigh, Mary P. O’Sullivan, Luke A. O’Neill, Maureen J. O’Sullivan, Joseph Keane

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis continues to rise. Consequently

Externí odkaz: https://doaj.org/article/d064450510e04e1fadfdf5fe4ddbe2b6

The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis

Autor: Fiona O'Connell, Christina Cahill, James J. Phelan, Joseph Keane, Donal J. Cox, Jacintha O'Sullivan, Cilian Ó'Maoldomhnaigh, Sharee A. Basdeo, Karl M. Gogan

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12189, p 12189 (2021)
Volume 22
Issue 22

Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were initially implemented based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f012c38b268d90a49a1660d472324f
http://europepmc.org/articles/PMC8624646