Výsledky vyhledávání - "Shared epitope"

Akademický článek

Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study

Autor: Marina I. Arleevskaya, Regina V. Larionova, Elena I. Shagimardanova, Natalia E. Gogoleva, Olga A. Kravtsova, Andrej A. Novikov, Gevorg G. Kazarian, Caroline Carlé, Yves Renaudineau

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

BackgroundA familial history of rheumatoid arthritis (RA) predisposes an individual to develop RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort.MethodsA total of 144 individuals, referred to as p

Externí odkaz: https://doaj.org/article/fd773793c0b9476b9da7f701026a7132

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Akademický článek

The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual 'window of treatment success' in RA patients

Autor: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina, Johan Rönnelid, Günter Steiner, Karl Skriner

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-16 (2021)

Abstract Background There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and citrullinated hete

Externí odkaz: https://doaj.org/article/6e28ab54dbcf4c858aedc3ba90e27fcf

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Akademický článek

Impact of the HLA-DRB1 shared epitope on responses to treatment with tofacitinib or abatacept in patients with rheumatoid arthritis

Autor: Wataru Hirose, Masayoshi Harigai, Koichi Amano, Toshihiko Hidaka, Kenji Itoh, Kazutoshi Aoki, Masahiro Nakashima, Hayato Nagasawa, Yukiko Komano, Toshihiro Nanki, for the TOF-ABT Study Group

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)

Abstract Objectives The aim of this study was to compare the clinical effectiveness of tofacitinib and abatacept and clarify the impact of the HLA-DRB1 shared epitope (SE) on responses to these treatments in patients with rheumatoid arthritis (RA). M

Externí odkaz: https://doaj.org/article/8072e3ec640d40be86ca5bbb0e68cc83

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Akademický článek

Antibodies to Citrullinated Protein Antigens, Rheumatoid Factor Isotypes and the Shared Epitope and the Near-Term Development of Clinically-Apparent Rheumatoid Arthritis

Autor: Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Background/PurposeIn rheumatoid arthritis (RA) autoantibodies including antibodies to citrullinated protein antigens (ACPA) and rheumatoid factor (RF) can be predictive of incident clinical RA. However, there is limited understanding of how antibody

Externí odkaz: https://doaj.org/article/c55d5c1e5a054515822d35369da9f6ce

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Akademický článek

Shared epitope and polymorphism of MICA and NKG2D encoding genes in Greek and Polish patients with rheumatoid arthritis

Autor: Joanna Wielińska, Katerina Tarassi, Milena Iwaszko, Katarzyna Kościńska, Barbara Wysoczańska, Evangelia Mole, Vasiliki Kitsiou, Jerzy Świerkot, Katarzyna Kolossa, Diamanto Kouniaki, Theofilos Athanassiades, Alexandra Tsirogianni, Katarzyna Bogunia-Kubik

Publikováno v: Central European Journal of Immunology, Vol 46, Iss 1, Pp 92-98 (2021)

The present study aimed to analyse and compare the distribution of MICA (rs1051792) and NKG2D/KLRK1 (rs1154831, rs1049174, rs2255336) polymorphisms in 61 Greek and 100 Polish patients with rheumatoid arthritis in relation to the presence of the HLA-D

Externí odkaz: https://doaj.org/article/7ef571b5e3ce4c03a31e3b9fc497a0e8

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Akademický článek

Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency

Autor: Takeshi Iwasaki, Shuichiro Nakabo, Chikashi Terao, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Yasuo Miura, Kimiko Yurugi, Taira Maekawa, Myrthe A. M. van Delft, Leendert A. Trouw, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)

Abstract Background The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may

Externí odkaz: https://doaj.org/article/c195d9a8f7024b4584db27527af4faa3

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Akademický článek

A Cost per Responder Model for Abatacept versus Adalimumab Among Rheumatoid Arthritis Patients with Seropositivity

Autor: Park SH, Han X, Lobo F, Nanji S, Patel D

Publikováno v: ClinicoEconomics and Outcomes Research, Vol Volume 12, Pp 589-594 (2020)

Sang Hee Park,1 Xue Han,2 Francis Lobo,2 Sakina Nanji,1 Dipen Patel1 1Modeling and Meta-Analysis, Pharmerit International, Bethesda, MD, USA; 2WW HEOR Markets-US, Bristol-Myers Squibb Company, Lawrenceville, NJ, USACorrespondence: Xue HanBristol-Myer

Externí odkaz: https://doaj.org/article/ca90f5045a5f45eead6ec7600633d724

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