Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sharavathi G, Parameswarappa"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1693-1699 (2020)
Streptococcus pneumoniae (SP) bacteria cause serious invasive diseases. SP bacteria are covered by a capsular polysaccharide (CPS) that is a virulence factor and the basis for SP polysaccharide and glycoconjugate vaccines. The serotype 9V is part of
Externí odkaz:
https://doaj.org/article/95c2ac40e5b74f84a49864facb7b42de
Autor:
Arun Naini, Max Peter Bartetzko, Someswara Rao Sanapala, Felix Broecker, Victoria Wirtz, Marilda P. Lisboa, Sharavathi G. Parameswarappa, Daniel Knopp, Jessica Przygodda, Matthias Hakelberg, Rosalind Pan, Axay Patel, Laurent Chorro, Arthur Illenberger, Christopher Ponce, Srinivas Kodali, Jacqueline Lypowy, Annaliesa S. Anderson, Robert G. K. Donald, Arne von Bonin, Claney L. Pereira
Publikováno v:
JACS Au. 2:2135-2151
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a38b04fabf01cd54cb00ae2e8b8595ce
https://doi.org/10.1021/jacsau.2c00401
https://doi.org/10.1021/jacsau.2c00401
Autor:
Paulina Kaplonek, Ling Yao, Katrin Reppe, Franziska Voß, Thomas Kohler, Friederike Ebner, Alexander Schäfer, Ulrike Blohm, Patricia Priegue, Maria Bräutigam, Claney L. Pereira, Sharavathi G. Parameswarappa, Madhu Emmadi, Petra Ménová, Martin Witzenrath, Sven Hammerschmidt, Susanne Hartmann, Leif E. Sander, Peter H. Seeberger
Publikováno v:
Vaccine
bioRxiv
bioRxiv
Streptococcus pneumoniae (S. pneumoniae) infections are the leading cause of child mortality globally. Current vaccines fail to induce a protective immune response towards a conserved part of the pathogen, resulting in new serotypes causing disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c7b2c9ac495244c7d58e1509e1a374
https://doi.org/10.1016/j.vaccine.2021.12.068
https://doi.org/10.1016/j.vaccine.2021.12.068
Publikováno v:
Beilstein Journal of Organic Chemistry
Streptococcus pneumoniae (SP) bacteria cause serious invasive diseases. SP bacteria are covered by a capsular polysaccharide (CPS) that is a virulence factor and the basis for SP polysaccharide and glycoconjugate vaccines. The serotype 9V is part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b75c8221a2478bc5b2e0eaa900ad3b9
https://pubmed.ncbi.nlm.nih.gov/32733612
https://pubmed.ncbi.nlm.nih.gov/32733612
Autor:
Benjamin, Schumann, Heung Sik, Hahm, Sharavathi G, Parameswarappa, Katrin, Reppe, Annette, Wahlbrink, Subramanian, Govindan, Paulina, Kaplonek, Liise-Anne, Pirofski, Martin, Witzenrath, Chakkumkal, Anish, Claney L, Pereira, Peter H, Seeberger
Publikováno v:
Science translational medicine. 9(380)
Glycoconjugate vaccines based on capsular polysaccharides (CPSs) of pathogenic bacteria such as Streptococcus pneumoniae successfully protect from disease, but suffer from incomplete coverage, are troublesome to manufacture from isolated CPSs and lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dc0c6b696c1cf1d37365ff0a7e2f774
https://pubmed.ncbi.nlm.nih.gov/28275152
https://pubmed.ncbi.nlm.nih.gov/28275152
Publikováno v:
The Journal of Organic Chemistry. 77:8038-8048
4-Alkylpyridines possessing nucleophilic β-dicarbonyl side chains have been converted to spirodihydropyridines upon treatment with ethyl chloroformate and sub-stoichiometric amounts of Ti(O(i)Pr)(4). Alternatively, inclusion of mild base in the reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc304265b339539b4fdde5643a81335
https://doi.org/10.1021/jo301247c
https://doi.org/10.1021/jo301247c
Publikováno v:
Organic Letters. 12:3434-3437
Pyridines substituted at the 4-position with alkyl tethers containing beta-dicarbonyl moieties were converted to spirocyclic 4,4-disubstituted dihydropyridines. Optimal conditions for these transformations involved N-acylation of the pyridine substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b33a769541cce24f7ff7b253a2ad3b9
https://doi.org/10.1021/ol1012636
https://doi.org/10.1021/ol1012636
Publikováno v:
Organic Letters. 12:2398-2401
A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690a2a8307b218d4e3599a8b4988bc01
https://doi.org/10.1021/ol100774p
https://doi.org/10.1021/ol100774p
Publikováno v:
Tetrahedron Letters. 52:4357-4359
Construction of 3,9-diazaspiro[5.5]undecane derivatives can be easily achieved via intramolecular spirocyclization of 4-substituted pyridines. The reaction entails in situ activation of the pyridine ring with ethyl chloroformate followed by intramole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d02a9874c8c87fcf41c759acd9e3e985
https://doi.org/10.1016/j.tetlet.2011.06.055
https://doi.org/10.1016/j.tetlet.2011.06.055
Publikováno v:
ChemInform. 44
Pyridines containing a β-keto amide moiety can be converted into spirocyclic dihydropyridines or lactams depending on the substitution pattern and the conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9efb16c40d55136fe84fb8507de1da
https://doi.org/10.1002/chin.201303034
https://doi.org/10.1002/chin.201303034