Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

Autor: Hazel Hall-Roberts, Sally A. Cowley, Elena Di Daniel, Sohaib Nizami, Sharat Warrier

Publikováno v: British Journal of Pharmacology

One of the largest unmet medical needs is a disease-modifying treatment for Alzheimer's disease (AD). Recently, the role of microglia in disease, particularly AD, has gained great interest, following the identification of several disease risk-associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d59d4add53333d50a6eab3ed7e7bbb8
https://doi.org/10.1111/bph.14618

WNT Inhibition and Increased FGF Signaling Promotes Derivation of Less Heterogeneous Primed Human Embryonic Stem Cells, Compatible with Differentiation

Autor: Björn Heindryckx, Filip Van Nieuwerburgh, Petra De Sutter, Margot Van der Jeught, Monika Bialecka, Mina Popovic, Björn Menten, Susana M. Chuva de Sousa Lopes, Jasin Taelman, Sharat Warrier, Kuniya Abe, Dieter Deforce, Laurentijn Tilleman

Publikováno v: Stem cells and development. 28(9)

Human embryonic stem cells (hESCs) hold great value for future clinical applications. However, standard culture conditions maintain hESCs in a primed state, which bears heterogeneity in pluripotency and a tendency for spontaneous differentiation. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a570b73c7592c3e4e2183f374c441238
https://pubmed.ncbi.nlm.nih.gov/30827199

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Autor: Lies Vantomme, Eva D’haene, Margot Van der Jeught, Sarah Vergult, Eva Van Lombergen, Björn Menten, Pieter-Jan Volders, Eva Z. Jacobs, Sharat Warrier, Björn Heindryckx

Publikováno v: Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee3fe1329ad6e44d288a2944e64e854
http://europepmc.org/articles/PMC5709416

Alternative Routes to Induce Naive Pluripotency in Human Embryonic Stem Cells

Autor: Susana M. Chuva de Sousa Lopes, Margot Van der Jeught, Matthias S Roost, Björn Heindryckx, Sharat Warrier, Pieter Mestdagh, Galbha Duggal, Luc Peelman, Björn Menten, Dieter Deforce, Petra De Sutter, Sabitri Ghimire, Jo Vandesompele, Bastiaan T. Heijmans, Sylvie Lierman, Tom Deroo, Roderick C. Slieker, Ria Cornelissen, Dorien Broekaert, Ann Van Soom

Publikováno v: Stem Cells, 33(9), 2686-2698. Wiley-Blackwell
Duggal, G, Warrier, S, Ghimire, S, Broekaert, D, Van Der Jeught, M, Lierman, S, Deroo, T, Peelman, L, Van Soom, A, Cornelissen, R, Menten, B, Mestdagh, P, Vandesompele, J, Roost, M, Slieker, R C, Heijmans, B T, Deforce, D, De Sutter, P, De Sousa Lopes, S C & Heindryckx, B 2015, ' Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells ', Stem Cells, vol. 33, no. 9, pp. 2686-2698 . https://doi.org/10.1002/stem.2071
STEM CELLS
STEM CELLS, 33(9), 2686-2698

Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state. Efforts have been made to trigger naïve pluripotency in hESCs for subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6db555b3a634e19273b62d1365d75d
https://hdl.handle.net/1887/105546

Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential

Autor: Galbha Duggal, Margot Van der Jeught, Tom Deroo, Liesbeth Vossaert, Susana M. Chuva de Sousa Lopes, Sharat Warrier, Dieter Deforce, Petra De Sutter, Sylvie Lierman, Björn Heindryckx, Thomas O'Leary

Publikováno v: STEM CELLS AND DEVELOPMENT
Stem Cells and Development, 22(23), 3141-3155

Human embryonic stem cells (hESCs) are more similar to “primed” mouse epiblast stem cells (mEpiSCs). mEpiSCs, which are derived in Activin A, show an increased propensity to form primordial germ cell (PGC)-like cells in response to bone morphogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c60385e9e19420cb0d3aa970d3c6f14
https://biblio.ugent.be/publication/4266511