Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sharanya Srinivasan"'
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 908-917 (2015)
We present self-cloning CRISPR/Cas9 (scCRISPR), a technology that allows for CRISPR/Cas9-mediated genomic mutation and site-specific knockin transgene creation within several hours by circumventing the need to clone a site-specific single-guide RNA (
Externí odkaz:
https://doaj.org/article/b7b0563cb5d44671b924139e2aae7348
Autor:
Amira A Barkal, Sharanya Srinivasan, Tatsunori Hashimoto, David K Gifford, Richard I Sherwood
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152683 (2016)
Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler t
Externí odkaz:
https://doaj.org/article/365f592869274a7d9338ddea133e73fe
Autor:
Stacy Mo, Baris E. Polat, Ross Barman, Robert Langer, Sharanya Srinivasan, Daniel Blankschtein, Carl M. Schoellhammer
Publikováno v:
PMC
Low-frequency ultrasound presents an attractive method for transdermal drug delivery. The controlled, yet non-specific nature of enhancement broadens the range of therapeutics that can be delivered, while minimizing necessary reformulation efforts fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d324fd9181b9d81312454ca43c300a7a
https://doi.org/10.1016/j.jconrel.2015.02.002
https://doi.org/10.1016/j.jconrel.2015.02.002
Publikováno v:
2015 IEEE International WIE Conference on Electrical and Computer Engineering (WIECON-ECE).
Variable frequency drive of single-phase induction motor can have many potential advantages, like reduced inrush current during starting, high starting torque, possibility of higher efficiency, more tolerant to variation in grid supply voltage etc. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8545c7da4e43cdf8c27fd9b16f07bf9c
https://doi.org/10.1109/wiecon-ece.2015.7443907
https://doi.org/10.1109/wiecon-ece.2015.7443907
Autor:
Haoyang Zeng, Sharanya Srinivasan, Amira A. Barkal, Daniel Kang, Nisha Rajagopal, Tommi S. Jaakkola, Bart J M Emons, David K. Gifford, Richard I. Sherwood, Tatsunori Hashimoto
Publikováno v:
Cold Spring Harbor Laboratory Press
Enhancers and promoters commonly occur in accessible chromatin characterized by depleted nucleosome contact; however, it is unclear how chromatin accessibility is governed. We show that log-additive cis-acting DNA sequence features can predict chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7664a261a846c5228ae452faa4ba4456
https://orcid.org/0000-0002-2199-0379
https://orcid.org/0000-0002-2199-0379
Autor:
Sharanya Srinivasan, Richard I. Sherwood, Amira A. Barkal, Tatsunori Hashimoto, David K. Gifford
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0152683 (2016)
Public Library of Science
PLoS ONE, Vol 11, Iss 3, p e0152683 (2016)
Public Library of Science
Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589405f2ba6629bf69785f4c22f715a0
https://doi.org/10.1371/journal.pone.0152683
https://doi.org/10.1371/journal.pone.0152683