Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sharanya Raghunath"'
Autor:
Nephi A. Walton, Brent Hafen, Sara Graceffo, Nykole Sutherland, Melanie Emmerson, Rachel Palmquist, Christine M. Formea, Maricel Purcell, Bret Heale, Matthew A. Brown, Christopher J. Danford, Sumathi I. Rachamadugu, Thomas N. Person, Katherine A. Shortt, G. Bryce Christensen, Jared M. Evans, Sharanya Raghunath, Christopher P. Johnson, Stacey Knight, Viet T. Le, Jeffrey L. Anderson, Margaret Van Meter, Teresa Reading, Derrick S. Haslem, Ivy C. Hansen, Betsey Batcher, Tyler Barker, Travis J. Sheffield, Bhaskara Yandava, David P. Taylor, Pallavi Ranade-Kharkar, Christopher C. Giauque, Kenneth R. Eyring, Jesse W. Breinholt, Mickey R. Miller, Payton R. Carter, Jason L. Gillman, Andrew W. Gunn, Kirk U. Knowlton, Joshua L. Bonkowsky, Kari Stefansson, Lincoln D. Nadauld, Howard L. McLeod
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 11, p 1867 (2022)
The clinical use of genomic analysis has expanded rapidly resulting in an increased availability and utility of genomic information in clinical care. We have developed an infrastructure utilizing informatics tools and clinical processes to facilitate
Externí odkaz:
https://doaj.org/article/8b0660b1dc4e4da79aa63cdd53ff0344
Autor:
Adrienne T. Perkins, Derrick Haslem, Jessica Goldsberry, Katherine Shortt, Laura Sittig, Sharanya Raghunath, Christopher Giauque, Shawnee Snow, Gail Fulde, Bryce Moulton, David Jones, Lincoln Nadauld
Publikováno v:
Cancers, Vol 13, Iss 22, p 5612 (2021)
Purpose: To accurately ascertain the frequency of pathogenic germline variants (PGVs) in a pan-cancer patient population with universal genetic testing and to assess the economic impact of receiving genetic testing on healthcare costs. Methods: In th
Externí odkaz:
https://doaj.org/article/caf8a4a6468242518ce58803bfb254a7
Autor:
Shawnee Snow, Christopher Giauque, Gail Fulde, Jessica Goldsberry, Bryce Moulton, Lincoln Nadauld, Derrick S. Haslem, David A. Jones, Adrienne T Perkins, Katherine Shortt, Laura Sittig, Sharanya Raghunath
Publikováno v:
Cancers
Volume 13
Issue 22
Cancers, Vol 13, Iss 5612, p 5612 (2021)
Volume 13
Issue 22
Cancers, Vol 13, Iss 5612, p 5612 (2021)
Simple Summary Clinical genetic testing likely underestimates the frequency of pathogenic germline variants (PGVs) in a cancer patient population due to strict qualifications designated by practice guidelines. Accurate ascertainment of PGVs in cancer
Autor:
Derrick S. Haslem, Su-Ho Hwang, Katherine Shortt, Timothy J. Yeatman, Ivan R Zendejas-Ruiz, Sharanya Raghunath, Gail Fulde, Zoya Sandhu, Ramya Thota, Tyler Barker, Jorge Sanchez-Garcia
Publikováno v:
Journal of Clinical Oncology. 39:e16191-e16191
e16191 Background: Biliary tract cancers are aggressive tumors with limited treatment options. Several ongoing clinical trials are currently exploring role of immune therapy in advanced BTC. Programmed death-ligand 1 (PD-L1), tumor mutational burden
Autor:
Archana Ramesh, Tom Neuwerth, Katherine Shortt, Chris Giauque, Christopher Johnson, Sharanya Raghunath
Publikováno v:
Cancer Research. 80:5454-5454
The analysis of Next Generation Sequencing (NGS) data relies on workflows that integrate different bioinformatics tools. Designing workflows that are assay agnostic and have a robust computational framework for result generation in a timely manner is
Autor:
Tyler Barker, Terence Duane Rhodes, Robin Romero, Tyler Abraham, Derrick S. Haslem, Lincoln Nadauld, Bryce Christensen, Mark A. Lewis, Ramya Thota, Gail Fulde, Bryce Moulton, Sharanya Raghunath
Publikováno v:
Journal of Clinical Oncology. 36:680-680
680 Background: Cyclin Dependent Kinases (CDKs) play a significant role in cell cycle regulation. Aberrations involving the cell cycle pathway genes can lead to uncontrolled cell proliferation and genomic instability. These could potentially be targe
Autor:
Lincoln Nadauld, Ramya Thota, Tyler Abraham, Sharanya Raghunath, Gail Fulde, Robin Romero, Tyler Barker, Mark A. Lewis, Bryce Moulton, Derrick S. Haslem, Bryce Christensen
Publikováno v:
Journal of Clinical Oncology. 36:647-647
647 Background: The clinical significance of the genomic alterations associated with DDR pathway in GI tumors (besides MMR defects) is largely unknown. These patients can potentially derive benefit from targeted therapy with poly ADP ribose polymeras
Autor:
Terence Duane Rhodes, Bryce Christensen, Tyler Barker, Gail Fulde, Robin Romero, Mark A. Lewis, Derrick S. Haslem, Tyler Abraham, Lincoln Nadauld, Sharanya Raghunath, Ramya Thota, Bryce Moulton
Publikováno v:
Journal of Clinical Oncology. 36:295-295
295 Background: HCC is a heterogeneous disease with diverse genomic alterations. The prior genomic studies have identified common alterations in TERT, P53, WNT pathways. However, most of these alterations are not targetable with current FDA approved
Autor:
Lincoln Nadauld, David Loughmiller, Sara King, Christopher D. Johnson, Moises Hernandez, Pravin J. Mishra, Sharanya Raghunath
Publikováno v:
Cancer Research. 77:5359-5359
Sequencing whole cancer exome and whole genome provides useful information to study cancer evolution. However, cost and amount of data may become overwhelming. Enrichment capture-based methods to design custom targeted gene panel have rapidly evolved
Autor:
Derrick S. Haslem, Lincoln Nadauld, Patrick Bradley, Pravin J. Mishra, Aimee Shamo, Gary Stone, Christopher D. Johnson, David Loughmiller, Jason Gillman, Jackie Wayne, Sharanya Raghunath, Moises Hernandez
Publikováno v:
Cancer Research. 76:3650-3650
In recent years, somatic mutation testing via Next Generation Sequencing (NGS) has emerged as a powerful tool to detect targetable mutations in diseases such as cancer. These include mutations such as BRAF V600E, which can lead to targeted drug thera