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pro vyhledávání: '"Sharanya M. Kalasekar"'
Autor:
Sharanya M. Kalasekar, Srishti Kotiyal, Christopher Conley, Cindy Phan, Annika Young, Kimberley J. Evason
Publikováno v:
Biology Open, Vol 8, Iss 10 (2019)
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin
Externí odkaz:
https://doaj.org/article/a18c7a30fa3041dba01856ebaf2b49b4
Publikováno v:
Cancers
Cancers, Vol 13, Iss 5524, p 5524 (2021)
Cancers, Vol 13, Iss 5524, p 5524 (2021)
Simple Summary Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that has poor patient outcomes and survival. Unlike many other cancers, HCC has not seen the benefit of individualized treatment. Part of the reason HCC is hard to treat i
Autor:
Sharanya M. Kalasekar, Kimberley J. Evason, Alexis Fulbright, Richard Smith, Gregory S. Ducker, Junko Kuramoto
Publikováno v:
Cancer Research. 80:3740-3740
Introduction: This study aimed to clarify the role of phosphatidylcholine (PC) and choline metabolites in β-catenin-driven hepatocellular carcinoma (HCC) using human HCC cell lines and transgenic zebrafish expressing hepatocyte-specific activated β