Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sharangdhar S. Phatak"'
Autor:
Indrani Dasgupta, Eric A Tanifum, Mayank Srivastava, Sharangdhar S Phatak, Claudio N Cavasotto, Mostafa Analoui, Ananth Annapragada
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29585 (2012)
Boronic acids, known to bind diols, were screened to identify non-inflammatory cross-linkers for the preparation of glucose sensitive and insulin releasing agglomerates of liposomes (Agglomerated Vesicle Technology-AVT). This was done in order to sel
Externí odkaz:
https://doaj.org/article/082412c9501449799387a163ffd5d043
Publikováno v:
Current Drug Metabolism. 18:1217-1239
As an important aspect of computer-aided drug design, structure-based drug design brought a new horizon to pharmaceutical development. This in silico method permeates all aspects of drug discovery today, including lead identification, lead optimizati
Autor:
Sharangdhar S. Phatak, Bokyung Sung, Subash C. Gupta, Bharat B. Aggarwal, Vivek R. Yadav, Sahdeo Prasad, Shuxing Zhang
Publikováno v:
Journal of Biological Chemistry. 287:245-256
3-Formylchromone (3-FC) has been associated with anticancer potential through a mechanism yet to be elucidated. Because of the critical role of NF-κB in tumorigenesis, we investigated the effect of this agent on the NF-κB activation pathway. Whethe
Autor:
Estrella-Jimenez Maria, Shuxing Zhang, Sharangdhar S. Phatak, Matthew J. Shashack, Juhienah Khalaf, Scott R. Gilbertson
Publikováno v:
ACS Combinatorial Science. 13:351-356
This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a
Autor:
Barkın Berk, Santiago Vilar, Giulio Ferino, Sharangdhar S. Phatak, Stefano Costanzi, Claudio N. Cavasotto
Publikováno v:
Journal of Molecular Graphics and Modelling. 29:614-623
G protein-coupled receptors (GPCRs) regulate a wide range of physiological functions and hold great pharmaceutical interest. Using the β(2)-adrenergic receptor as a case study, this article explores the applicability of docking-based virtual screeni
Autor:
Mohamed Naguib, Charles M. Thompson, Fanny Astruc-Diaz, Frank R. Fronczek, Jijun Xu, Philippe Diaz, Claudio N. Cavasotto, Sharangdhar S. Phatak
Publikováno v:
ChemMedChem. 4:1615-1629
We recently discovered and reported a series of N-alkyl-isatin acylhydrazone derivatives that are potent cannabinoid receptor 2 (CB(2)) agonists. In an effort to improve the druglike properties of these compounds and to better understand and improve
Publikováno v:
Drug Discovery Today. 14:676-683
As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a
Autor:
Sharangdhar S. Phatak, Shaun R. Stauffer, Craig W. Lindsley, Joel M. Harp, Michael L. Schulte, Mark Turlington
Publikováno v:
ChemInform. 45
Autor:
Shaun R. Stauffer, Michael L. Schulte, Mark Turlington, Sharangdhar S. Phatak, Craig W. Lindsley, Joel M. Harp
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 19(36)
The Stemona alkaloids represent a class of more than eighty structurally diverse alkaloids isolated from plants belonging to the Stemonaceae family.[1] Structurally these alkaloids are characterized by the conserved pyrrolo[1,2-a]azepine core usually
Autor:
Sharangdhar S, Phatak, Shuxing, Zhang
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.
Exploiting drug polypharmacology to identify novel modes of actions for drug repurposing has gained significant attentions in the current era of weak drug pipelines. From a serendipitous to systematic or rational ways, a variety of unimodal computati