Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sharanabasava B. Rajur"'
Publikováno v:
Tetrahedron Letters. 44:5665-5668
Unlike the migration of a methyl group observed in the ZnCl 2 or acetic acid-catalysed indolisation of phenylhydrazones, dry ethanolic HCl catalysed indolisation of 2,6-dimethyl- and 2,4,6-trimethylphenylhydrazones of various substituted butane-2,3-d
Publikováno v:
Bioconjugate Chemistry. 8:119-126
A series of DNA conjugates have been prepared in which two different derivatives of Hoechst 33258 have been tethered to a sequence containing a 5'-GAATTC-3' target site. The two derivatives differ only in the length of the tether between the DNA and
Autor:
Kristin Wiederholt, Sharanabasava B. Rajur, and Maryanne J. O'Donnell, John S. Giuliano, Larry W. McLaughlin
Publikováno v:
Journal of the American Chemical Society. 118:7055-7062
Fluorescent Hoechst 33258 analogues have been synthesized in which the terminal phenol moiety is employed as a site for the introduction of a linker to permit covalent attachment of the fluorophores to oligo(deoxynucleotides). Hybridization by the DN
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:743-750
A small Hoechst-like DNA groove-binding fluorophore carrying a terminal bromoacetimido linker has been synthesized. Individual diastereomeric oligodeoxynucleotide dodecamers containing a thiol-based linker attached to an internucleotide phosphoramida
Publikováno v:
Biochemistry. 33:13903-13909
Two guanosine 2'-hydroxyls in the hammerhead RNA complex at positions G5 and G8 are critical for efficient cleavage by this RNA catalyst. These two functional groups are likely involved in the binding of the metal cofactor, or they are involved in sp
Autor:
Matthew J. Taylor, Stacia M. Rink, Sharanabasava B. Rajur, Marjorie S. Solomon, Paul B. Hopkins, Larry W. McLaughlin
Publikováno v:
Journal of the American Chemical Society. 115:2551-2557
The covalent structure of the major product of the interstrand cross-linking reaction of mechlorethamine [bis(2-chloroethyl)methylamine, nitrogen mustard] with duplex DNA was determined using synthetic oligodeoxyribonucleotide duplexes. Analysis of t
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
An easy synthesis of 3,5-disubstituted-2-actylindoles by the HC1 cyclization of the corresponding phenylhydrazones is described.
Publikováno v:
Tetrahedron Letters. 33:6081-6084
A procedure is described for the Preparation of two thymidine analogues in which the O 2 -carbonyl is deleted (d H 2 T) or converted to an O 2 -thione (ds 2 T). The phosphoramidites of these nucleosides have been synthesized and used to incorporate t
Publikováno v:
Biochemistry. 31:5925-5936
A series of modified trp operator sequences has been prepared by the incorporation of seven different base analogues. Four of the analogues allow the site-specific deletion of functional groups present on the dA-dT and dT-dA base pairs at positions -